Adamantanine  (Synonyms: 2-Aminoadamantane-2-carboxylic acid)

Adamantanine (2-Aminoadamantane-2-carboxylic acid) inhibits the transport of methionine (K_i is 0.76 mM) and leucine into Ehrlich ascites carcinoma cells. Adamantanine inhibits proliferation of P388 lymphocytic leukemia cells with an IC₅₀ of >1 mM. Adamantanine inhibits the leucine aminopeptidase with an I/S_0.5 of 10.5^[1].

Adamantanine (500 mg/kg, i.p., single dose; 1000 mg/kg, p.o., single dose) is non-toxic in Sprague Dawley rats model as a a finely pulverized suspension^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

195.26

C₁₁H₁₇NO₂

42381-05-5

Solid

Off-white to brown

OC(C1([C@H]2C[C@H](C3)C[C@@H]1C[C@H]3C2)N)=O

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Nagasawa HT, et al., Potential latentiation forms of biologically active compounds based on action of leucine aminopeptidase. Dipeptide derivatives of the tricycloaliphatic alpha-amino acid, adamantanine. J Med Chem. 1975 Aug;18(8):826-30.  [Content Brief]

  [2]. Nagaswa HT, et al., 2-Aminoadamantane-2-carboxylic acid, a rigid, achiral, tricyclic alpha-amino acid with transport inhibitory properties. J Med Chem. 1973 Jul;16(7):823-6.  [Content Brief]