METAP1/Methionine aminopeptidase 1 Protein, Human

METAP1 (or methionine aminopeptidase 1) plays a crucial role in protein synthesis by co-translationally removing N-terminal methionine from nascent proteins.This enzymatic activity is particularly relevant when the second residue in the primary sequence is small and uncharged (including residues such as Ala, Cys, Gly, Pro, Ser, Thr or Val).METAP1/Methionine aminopeptidase 1 Protein, Human is the recombinant human-derived METAP1/Methionine aminopeptidase 1 protein, expressed by E.coli , with tag free.

METAP1, or Methionine Aminopeptidase 1, is a protein crucial for protein synthesis regulation. It cotranslationally eliminates the N-terminal methionine from nascent proteins, especially when the second residue in the primary sequence is a small and uncharged amino acid, such as Met-Ala, Cys, Gly, Pro, Ser, Thr, or Val. This activity is vital for proper maturation and function of proteins. Additionally, METAP1 plays a pivotal role in cellular processes by being required for normal progression through the cell cycle. Its involvement in the cell cycle underscores its significance in fundamental biological events, further emphasizing its role in maintaining cellular homeostasis and proper functioning.

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

E. coli

Tag Free

P53582 (M1-F386)

23173  [NCBI]

MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMSQF

38-50 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Solution

Supplied as a 0.2 μm filtered solution of 20 mM Glycine, 10% Sucrose, 10% Glycerol, 0.02% Tween80, pH 3.5.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.