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polyene

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (15) Apoptosis (2) Bacterial (9) Endogenous Metabolite (1) Fungal (18) HIV (2) Isotope-Labeled Compounds (1) Parasite (4)
By Research Areas:	Cancer (7) Infection (20) Inflammation/Immunology (2)

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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B2235

Lecithin 4 Publications Verification polyene phosphatidylcholine	Endogenous Metabolite	Others
Lecithin is regarded as a safe, conventional phospholipid source. Phospholipids are reported to alter the fatty acid composition and microstructure of the membranes in animal cells.

HY-106681

Lagosin Fungichromin; Pentamycin; Cogomycin	Antibiotic Fungal	Cancer
Lagosin (Fungichromin) is a polyene macrolide antibiotic. Lagosin has demonstrated broad-spectrum antifungal activity and is impervious to agent resistance .

HY-N6716

Filipin complex 10+ Cited Publications	Fungal Antibiotic	Infection
Filipin complex is a potent polyene macrolide antifungal antibiotic. Filipin complex inserts into membranes and sequester cholesterol into complexes and inhibits PRRSV entry. The Filipin complex consists of about 75.8% Filipin III (HY-N6718), 10.8% Filipin IV, 9.1% Filipin II, and 1.2% Filipin I .

HY-125617

α-Lipomycin	Antibiotic Bacterial	Infection
α-Lipomycin is an acyclic polyene antibiotic isolated from the gram-positive bacterium Streptomyces aureofaciens Tü117 .

HY-112663

Monazomycin	Antibiotic	Infection
Monazomycin is a polyene-like antibiotic produced by Streptomyces. Monazomycin molecular weight is about 1200 .

HY-108874

Candicidin Levorin; Vanobid; Candimon	Antibiotic Fungal Bacterial	Infection
Candicidin is a polyene antifungal antibiotic agent and can be isolated from Streptomyces griseus or Actinomyces levoris .

HY-126783

Levorin A0 11-Deoxycandicidin D	Antibiotic
Levorin A0 is a Levorin component. Levorin is an aromatic polyene (heptaene) antibiotic with high antifungal activity.

HY-N11878

Terpenomycin	Fungal	Infection
Terpenomycin, a polyene derived from human pathogenic Nocardia terpenica isolates, has cytotoxic and antifungal activity .

HY-129728

Lienomycin	Antibiotic Fungal Bacterial	Infection Inflammation/Immunology Cancer
Lienomycin, a polyene antibiotic produced by Actinomyces distatochromogenes var. lienomycini, exhibits antifungal, antibacterial and antitumor activity .

HY-165123

Mepartricin	Fungal Parasite	Infection
Mepartricin is a polyene macrolide with antifungal and antiprotozoal activities, widely used in research related to benign prostatic hyperplasia .

HY-109125A

Amcipatricin L-aspartate SPA-S-753; SPA-S-752 L-aspartate	Antibiotic Fungal	Infection
Amcipatricin diaspartate (SPA-S-753) is a semi-synthetic polyene antibiotic, with potent broad-spectrum antifungal activity .

HY-120753

Rimocidin	Fungal	Infection
Rimocidin, a polyene macrolide, is an antifungal compound. Rimocidin shows broad‐spectrum antifungal activity against multiple plant‐pathogenic fungi .

HY-161091

AM-2-19	Fungal	Infection
AM-2-19 (SF001) is an ergosterol-extracting polyene antifungal that is discovered through modifications to the amphotericin B toxin by chemists .

HY-B0221

Amphotericin B 10+ Cited Publications	Fungal Antibiotic Bacterial Parasite	Infection Cancer
Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.

HY-B0221A

Amphotericin B trihydrate	Antibiotic Fungal Bacterial Parasite	Infection Inflammation/Immunology Cancer
Amphotericin B trihydrate, a polyene antibiotic, is first isolated from fermenter cultures of Streptomyces nodosus. Amphotericin B trihydrate also possesses antileishmanial activity .

HY-B0221R

Amphotericin B (Standard)	Fungal Antibiotic Bacterial Parasite	Infection Cancer
Amphotericin B (Standard) is the analytical standard of Amphotericin B. This product is intended for research and analytical applications. Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.

HY-121050

Ambruticin W7783	Antibiotic Fungal	Infection
Ambruticin (W7783) is an orally active and potent antifungal antibiotic. Ambruticin represents a class of antibiotics, that can be isolated from a strain of Polyangium cellulosum var. fulvum, a bacterium belonging to the class Myxobacteriales. Ambruticin is a cyclopropyl-polyene-pyran acid and is active against fungi .

HY-B0221S

Amphotericin B-13C6	Isotope-Labeled Compounds	Cancer
Amphotericin B- ¹³C₆ is ¹³C labeled Amphotericin B (HY-B0221). Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.

HY-159666

Nystatin A1	Antibiotic Fungal	Infection
Nystatin A1 is a polyene macrolide antifungal antibiotic that can be isolated from Streptomyces noursei. Nystatin A1 binds to ergosterol on the fungal cell membrane, increasing the permeability of the cell membrane and causing leakage of cell contents, thereby inhibiting the growth and reproduction of fungi .

HY-135327

Amphotericin B methyl ester	HIV Fungal	Infection
Amphotericin B methyl ester is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250). Amphotericin B methyl ester is the cholesterol-binding compound possesses significant antifungal activity. Amphotericin B methyl ester disrupts HIV-1 particle production and potently inhibits HIV-1 replication .

HY-135327A

Amphotericin B methyl ester hydrochloride	HIV Fungal	Infection
Amphotericin B methyl ester hydrochloride is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250). Amphotericin B methyl ester hydrochloride is the cholesterol-binding compound possesses significant antifungal activity. Amphotericin B methyl ester hydrochloride disrupts HIV-1 particle production and potently inhibits HIV-1 replication .

HY-17409

Nystatin Maximum Cited Publications 26 Publications Verification	Fungal Antibiotic Apoptosis Bacterial	Infection Cancer
Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma. Nystatin increases the permeability of plasma membranes to small monovalent ions, including chloridion . Nystatin is a cholesterol-sequestering agent , partially prevents Oxaliplatin-induced lipid raft aggregation, DR4 and DR5 clustering, and thereby reduces apoptosis .

HY-17409R

Nystatin (Standard)	Fungal Antibiotic Apoptosis Bacterial	Infection
Nystatin (Standard) is the analytical standard of Nystatin. This product is intended for research and analytical applications. Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma. Nystatin increases the permeability of plasma membranes to small monovalent ions, including chloridion . Nystatin is a cholesterol-sequestering agent , partially prevents Oxaliplatin-induced lipid raft aggregation, DR4 and DR5 clustering, and thereby reduces apoptosis .

HY-N11756

Linearmycin A	Bacterial	Infection
Linearmycin A is a polyene antibiotic that has been found in Streptomyces. It is active against the bacteria S. aureus and E. coli (MICs=3.1 and 1.6 μg/disc, respectively), the fungi S. cerevisiae and C. albicans (MICs=0.1 and 1.6 μg/disc, respectively), and the plant pathogenic fungus A. niger in disc assays (MIC=0.2 μg/disc). Linearmycin A induces lysis and degradation of B. subtilis as a component of Streptomyces Mg1 extract.

Cat. No.	Product Name	Type

HY-N6716

Filipin complex 10+ Cited Publications	Fluorescent Dyes/Probes
Filipin complex is a potent polyene macrolide antifungal antibiotic. Filipin complex inserts into membranes and sequester cholesterol into complexes and inhibits PRRSV entry. The Filipin complex consists of about 75.8% Filipin III (HY-N6718), 10.8% Filipin IV, 9.1% Filipin II, and 1.2% Filipin I .

Amphotericin B, Sterile
MCE Amphotericin B is a polyene antifungal antibiotic produced by Streptomyces nodosus. It can bind with sterols to form transmembrane channels, resulting in the leakage of intracellular substances, thus inhibiting fungal and yeast contamination.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B2235

Lecithin 4 Publications Verification polyene phosphatidylcholine	Structural Classification Natural Products Classification of Application Fields Source classification Endocrine diseases Plants Endogenous metabolite Microorganisms Leguminosae Glycine max (L.) merr Disease markers Other Diseases Disease Research Fields	Endogenous Metabolite
Lecithin is regarded as a safe, conventional phospholipid source. Phospholipids are reported to alter the fatty acid composition and microstructure of the membranes in animal cells.

HY-106681

Lagosin Fungichromin; Pentamycin; Cogomycin	Structural Classification Microorganisms Antifungal Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Disease Research Disease Research Fields Cancer	Antibiotic Fungal
Lagosin (Fungichromin) is a polyene macrolide antibiotic. Lagosin has demonstrated broad-spectrum antifungal activity and is impervious to agent resistance .

HY-N6716

Filipin complex 10+ Cited Publications	Structural Classification Microorganisms Antifungal Classification of Application Fields Antibiotics Source classification Other Diseases Antiviral Disease Research Disease Research Fields Other Antibiotics	Fungal Antibiotic
Filipin complex is a potent polyene macrolide antifungal antibiotic. Filipin complex inserts into membranes and sequester cholesterol into complexes and inhibits PRRSV entry. The Filipin complex consists of about 75.8% Filipin III (HY-N6718), 10.8% Filipin IV, 9.1% Filipin II, and 1.2% Filipin I .

HY-B0221

Amphotericin B 10+ Cited Publications	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Fungal Antibiotic Bacterial Parasite
Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.

HY-112663

Monazomycin	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	Antibiotic
Monazomycin is a polyene-like antibiotic produced by Streptomyces. Monazomycin molecular weight is about 1200 .

HY-126783

Levorin A0 11-Deoxycandicidin D	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification	Antibiotic
Levorin A0 is a Levorin component. Levorin is an aromatic polyene (heptaene) antibiotic with high antifungal activity.

HY-N11878

Terpenomycin	Structural Classification Natural Products Microorganisms Source classification	Fungal
Terpenomycin, a polyene derived from human pathogenic Nocardia terpenica isolates, has cytotoxic and antifungal activity .

HY-129728

Lienomycin	Structural Classification Microorganisms Antibiotics Source classification	Antibiotic Fungal Bacterial
Lienomycin, a polyene antibiotic produced by Actinomyces distatochromogenes var. lienomycini, exhibits antifungal, antibacterial and antitumor activity .

HY-120753

Rimocidin	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Disease Research Fields	Fungal
Rimocidin, a polyene macrolide, is an antifungal compound. Rimocidin shows broad‐spectrum antifungal activity against multiple plant‐pathogenic fungi .

HY-B0221A

Amphotericin B trihydrate	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Inflammation/Immunology Disease Research Fields	Antibiotic Fungal Bacterial Parasite
Amphotericin B trihydrate, a polyene antibiotic, is first isolated from fermenter cultures of Streptomyces nodosus. Amphotericin B trihydrate also possesses antileishmanial activity .

HY-B0221R

Amphotericin B (Standard)	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Fungal Antibiotic Bacterial Parasite
Amphotericin B (Standard) is the analytical standard of Amphotericin B. This product is intended for research and analytical applications. Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.

HY-121050

Ambruticin W7783	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Fungal
Ambruticin (W7783) is an orally active and potent antifungal antibiotic. Ambruticin represents a class of antibiotics, that can be isolated from a strain of Polyangium cellulosum var. fulvum, a bacterium belonging to the class Myxobacteriales. Ambruticin is a cyclopropyl-polyene-pyran acid and is active against fungi .

HY-17409

Nystatin Maximum Cited Publications 26 Publications Verification	Infection Structural Classification Microorganisms Antifungal Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Mammalian Cell Culture Disease Research Disease Research Fields	Fungal Antibiotic Apoptosis Bacterial
Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma. Nystatin increases the permeability of plasma membranes to small monovalent ions, including chloridion . Nystatin is a cholesterol-sequestering agent , partially prevents Oxaliplatin-induced lipid raft aggregation, DR4 and DR5 clustering, and thereby reduces apoptosis .

HY-17409R

Nystatin (Standard)	Structural Classification Microorganisms Antifungal Macrolide Antibiotics Antibiotics Source classification Mammalian Cell Culture Disease Research	Fungal Antibiotic Apoptosis Bacterial
Nystatin (Standard) is the analytical standard of Nystatin. This product is intended for research and analytical applications. Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma. Nystatin increases the permeability of plasma membranes to small monovalent ions, including chloridion . Nystatin is a cholesterol-sequestering agent , partially prevents Oxaliplatin-induced lipid raft aggregation, DR4 and DR5 clustering, and thereby reduces apoptosis .

HY-N11756

Linearmycin A	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Bacterial
Linearmycin A is a polyene antibiotic that has been found in Streptomyces. It is active against the bacteria S. aureus and E. coli (MICs=3.1 and 1.6 μg/disc, respectively), the fungi S. cerevisiae and C. albicans (MICs=0.1 and 1.6 μg/disc, respectively), and the plant pathogenic fungus A. niger in disc assays (MIC=0.2 μg/disc). Linearmycin A induces lysis and degradation of B. subtilis as a component of Streptomyces Mg1 extract.

Cat. No.	Product Name	Chemical Structure

HY-B0221S

Amphotericin B-13C6
Amphotericin B- ¹³C₆ is ¹³C labeled Amphotericin B (HY-B0221). Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.

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polyene

Inhibitors & Agonists

Fluorescent Dye

MCE Kits

NaturalProducts

Isotope-Labeled Compounds

Natural
Products