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  3. HIV Fungal
  4. Amphotericin B methyl ester

Amphotericin B methyl ester is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250). Amphotericin B methyl ester is the cholesterol-binding compound possesses significant antifungal activity. Amphotericin B methyl ester disrupts HIV-1 particle production and potently inhibits HIV-1 replication.

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Amphotericin B methyl ester Chemical Structure

Amphotericin B methyl ester Chemical Structure

CAS No. : 36148-89-7

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5 mg USD 80 In-stock
10 mg USD 130 In-stock
25 mg USD 260 In-stock
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Other Forms of Amphotericin B methyl ester:

Amphotericin B methyl ester Related Antibodies

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Description

Amphotericin B methyl ester is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250). Amphotericin B methyl ester is the cholesterol-binding compound possesses significant antifungal activity. Amphotericin B methyl ester disrupts HIV-1 particle production and potently inhibits HIV-1 replication[1][2].

In Vitro

Amphotericin B methyl ester inhibits HIV-1 particle production with no significant effect on Gag binding to the plasma membrane, Gag association with lipid rafts, or Gag multimerization[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Amphotericin B methyl ester Related Antibodies
Molecular Weight

938.11

Formula

C48H75NO17
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

COC([C@H]1[C@@]2([H])O[C@](O)(C[C@H](C[C@H]([C@@H](CC[C@H](C[C@H](CC(O[C@H]([C@@H]([C@H](O)[C@@H](C)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](O[C@@]3([H])[C@H]([C@H]([C@H](O)[C@@H](C)O3)N)O)C2)C)C)=O)O)O)O)O)O)C[C@@H]1O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (53.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0660 mL 5.3299 mL 10.6597 mL
5 mM 0.2132 mL 1.0660 mL 2.1319 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0660 mL 5.3299 mL 10.6597 mL 26.6493 mL
5 mM 0.2132 mL 1.0660 mL 2.1319 mL 5.3299 mL
10 mM 0.1066 mL 0.5330 mL 1.0660 mL 2.6649 mL
15 mM 0.0711 mL 0.3553 mL 0.7106 mL 1.7766 mL
20 mM 0.0533 mL 0.2665 mL 0.5330 mL 1.3325 mL
25 mM 0.0426 mL 0.2132 mL 0.4264 mL 1.0660 mL
30 mM 0.0355 mL 0.1777 mL 0.3553 mL 0.8883 mL
40 mM 0.0266 mL 0.1332 mL 0.2665 mL 0.6662 mL
50 mM 0.0213 mL 0.1066 mL 0.2132 mL 0.5330 mL
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Amphotericin B methyl ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amphotericin B methyl ester36148-89-7HIVFungalHuman immunodeficiency virusderivativecholesterol-bindingantifungalreplicationHIV-1Inhibitorinhibitorinhibit

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Amphotericin B methyl ester
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