Nystatin A1

Cat. No.: HY-159666: FAQs
Data Sheet Handling Instructions

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Nystatin A1 is a polyene macrolide antifungal antibiotic that can be isolated from Streptomyces noursei. Nystatin A1 binds to ergosterol on the fungal cell membrane, increasing the permeability of the cell membrane and causing leakage of cell contents, thereby inhibiting the growth and reproduction of fungi.

For research use only. We do not sell to patients.

Nystatin A1 Chemical Structure

CAS No. : 34786-70-4

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEp-2	CC₅₀	13.6 μg/mL Compound: Nystatin	Cytotoxicity against human HEp-2 cells assessed as reduction in cell viability incubated for 40 to 60 mins by resazurin dye based assay Cytotoxicity against human HEp-2 cells assessed as reduction in cell viability incubated for 40 to 60 mins by resazurin dye based assay	[PMID: 35178173]
HEp-2	CC₅₀	78 units/mg Compound: Nystatin	Cytotoxicity against human HEp-2 cells assessed as reduction in cell viability incubated for 40 to 60 mins by resazurin dye based assay Cytotoxicity against human HEp-2 cells assessed as reduction in cell viability incubated for 40 to 60 mins by resazurin dye based assay	[PMID: 35178173]
WI-38	CC₅₀	48.56 μM Compound: Nystatin	Cytotoxicity against human WI38 cells assessed as reduction in cellular DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay Cytotoxicity against human WI38 cells assessed as reduction in cellular DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay	[PMID: 17893158]
WI-38	EC₅₀	9.81 μM Compound: Nystatin	Antiviral activity against BKV Gardner ATCC VR837 infected in human WI38 cells assessed as reduction in viral DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay Antiviral activity against BKV Gardner ATCC VR837 infected in human WI38 cells assessed as reduction in viral DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay	[PMID: 17893158]

Molecular Weight

926.09

Formula

C₄₇H₇₅NO₁₇

CAS No.

34786-70-4

SMILES

O=C([C@H]1[C@]2([H])C[C@@H](O[C@H]3[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O3)/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O2)(O)C[C@@H]1O)=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Michel, et al. "Nystatin." Analytical profiles of drug substances. Vol. 6. Academic Press, 1977. 341-421. [Content Brief]

Nystatin A1 Related Classifications

Infection

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nystatin A134786-70-4Nystatin A 1Nystatin A-1AntibioticFungalAntibioticsfungiergosterolcell membranesInhibitorinhibitorinhibit

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