sterol compound

By Targets:	Apoptosis (2) Autophagy (1) Cytochrome P450 (1) Endogenous Metabolite (1) Fungal (2) p38 MAPK (1) Potassium Channel (1) PROTACs (1) Reactive Oxygen Species (1)
By Research Areas:	Cancer (3) Infection (3) Inflammation/Immunology (1) Metabolic Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0410

Daucosterol 5 Publications Verification Eleutheroside A; β-Sitosterol β-D-glucoside	Apoptosis Reactive Oxygen Species Autophagy	Inflammation/Immunology Cancer
Daucosterol is an orally active natural sterol compound, which has anti-inflammatory, anticancer and immunomodulatory activities. Daucosterol inhibits cancer cell proliferation by inducing autophagy through ROS-dependent manner. Daucosterol also inhibits colon cancer growth by inducing apoptosis, inhibiting cell migration and invasion and targeting caspase signalling pathway .

HY-N7255

Cycloartenol	p38 MAPK Apoptosis	Cancer
Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development .

HY-162351

EBP-IN-1	Others	Metabolic Disease
EBP-IN-1 (compound 11) is an inhibitor of emopamil-binding protein (EBP), a sterol isomerase in the cholesterol biosynthetic pathway. EBP-IN-1 has a long half-life in rodents and has good metabolic turnover and brain penetration properties. EBP-IN-1 enhances oligodendrocyte formation in human cortical organoids .

HY-158728

28-Deoxybetulin methyleneamine	Others	Others
28-Deoxybetulin methyleneamine (compound 36) is a derivative of Betulin. Betulin (HY-N0083) is a sterol regulatory element-binding protein (SREBP) inhibitor .

HY-D2336

PROTAC Aster-A degrader-1	PROTACs	Cancer
PROTAC Aster-A degrader-1 (compound NGF3) is a degrader of the sterol transport protein Aster-A. PROTAC Aster-A degrader-1 can be used as a fluorescence probe. (Red: Aster-A inhibitor, black: linker, Blue: E3 ligase ligand) .

HY-163631

Antibacterial agent 218	Fungal Endogenous Metabolite	Infection
Antibacterial agent 218 (compound d28) is an orally active sterol 24-C-Methyltransferase inhibitor with the IC₅₀ of 0.273 μM. Antibacterial agent 218 shows antifungal activity against the C.albicans SC5314 with the IC₅₀ of 0.25 μg/mL .

HY-W422288

(Rac)-Ketoconazole (Rac)-Ketoconazol; (Rac)-R 41400	Fungal Cytochrome P450	Infection
(Rac)-Ketoconazole ((Rac)-R 41400) is an antifungal imidazole compound with oral activity. (Rac)-Ketoconazole interferes with ergosterol synthesis by inhibiting cytochrome P450-dependent 14α-sterol demethylase (CYP51), a key enzyme on the fungal cell membrane, leading to membrane dysfunction and ultimately inhibition of fungal growth and reproduction. (Rac)-Ketoconazole is indicated for studies of fungal infections .

HY-118843

Lombazole	Potassium Channel	Infection
Lombazole is an antimicrobial compound with activity that inhibits cell membrane synthesis. Lombazole had little effect on K+ permeability in S. aureus. Lombazole inhibited only de novo synthesis of cell enclosure in S. aureus, and this effect occurred before growth was affected. The main effect of lombazole was through inhibition of lipid synthesis. Lombazole may have an effect on key steps in lipid biosynthesis, as inferred from the lack of changes in lipid patterns after treatment. Lombazole also inhibited the sterol C-14 demethylation step in Candida albicans .

Cat. No.	Product Name

HY-L091

Lipid Metabolism Compound Library	664 compounds
Lipids are a fundamental class of organic molecules implicated in a wide range of biological processes, and based on this can be broadly classified into five categories: fatty acids, triacylglycerols (TAGs), phospholipids, sterol lipids and sphingolipids. Lipids play a crucial role in different metabolic pathways and cellular functions. Lipid metabolism is an important physiological process that is related to nutrient adjustment, hormone regulation, and homeostasis. Lipid metabolism dysregulation is associated with many diseases such as obesity, liver disease, aging and inflammation. MCE offers a unique collection of 664 compounds related to lipid metabolism, which target relevant targets in the process of lipid metabolism, such as ATGL, MAGL, FAAH, acetyl-Coa Carboxylase, FASN, etc. MCE lipid metabolism compound library is a useful tool for research lipid metabolism and drug discovery of diseases related to lipid metabolism.

Lipid Metabolism Compound Library

664 compounds

Lipids are a fundamental class of organic molecules implicated in a wide range of biological processes, and based on this can be broadly classified into five categories: fatty acids, triacylglycerols (TAGs), phospholipids, sterol lipids and sphingolipids. Lipids play a crucial role in different metabolic pathways and cellular functions. Lipid metabolism is an important physiological process that is related to nutrient adjustment, hormone regulation, and homeostasis. Lipid metabolism dysregulation is associated with many diseases such as obesity, liver disease, aging and inflammation.

MCE offers a unique collection of 664 compounds related to lipid metabolism, which target relevant targets in the process of lipid metabolism, such as ATGL, MAGL, FAAH, acetyl-Coa Carboxylase, FASN, etc. MCE lipid metabolism compound library is a useful tool for research lipid metabolism and drug discovery of diseases related to lipid metabolism.

Cat. No.	Product Name	Type

HY-D2336

PROTAC Aster-A degrader-1	Fluorescent Dyes/Probes
PROTAC Aster-A degrader-1 (compound NGF3) is a degrader of the sterol transport protein Aster-A. PROTAC Aster-A degrader-1 can be used as a fluorescence probe. (Red: Aster-A inhibitor, black: linker, Blue: E3 ligase ligand) .

Cat. No.	Product Name	Type

HY-167809

1-Palmitoyl-2-cholesterylcarbonoyl-sn-glycero-3-phosphocholine	Drug Delivery
1-Palmitoyl-2-cholesterylcarbonoyl-sn-glycero-3-phosphocholine is a sterol-modified phospholipid with the activity of maintaining the stability of membrane bilayer structure and enhancing the liposome-mediated compound delivery process. 1-Palmitoyl-2-cholesterylcarbonoyl-sn-glycero-3-phosphocholine is widely used in biomedical applications to improve the delivery efficiency of compounds. 1-Palmitoyl-2-cholesterylcarbonoyl-sn-glycero-3-phosphocholine can also improve the release and distribution of compounds in cells.

1-Palmitoyl-2-cholesterylcarbonoyl-sn-glycero-3-phosphocholine

Drug Delivery

1-Palmitoyl-2-cholesterylcarbonoyl-sn-glycero-3-phosphocholine is a sterol-modified phospholipid with the activity of maintaining the stability of membrane bilayer structure and enhancing the liposome-mediated compound delivery process. 1-Palmitoyl-2-cholesterylcarbonoyl-sn-glycero-3-phosphocholine is widely used in biomedical applications to improve the delivery efficiency of compounds. 1-Palmitoyl-2-cholesterylcarbonoyl-sn-glycero-3-phosphocholine can also improve the release and distribution of compounds in cells.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0410

Daucosterol 5 Publications Verification Eleutheroside A; β-Sitosterol β-D-glucoside	Structural Classification Classification of Application Fields Source classification Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Disease Research Fields Araliaceae Steroids Cancer	Apoptosis Reactive Oxygen Species Autophagy
Daucosterol is an orally active natural sterol compound, which has anti-inflammatory, anticancer and immunomodulatory activities. Daucosterol inhibits cancer cell proliferation by inducing autophagy through ROS-dependent manner. Daucosterol also inhibits colon cancer growth by inducing apoptosis, inhibiting cell migration and invasion and targeting caspase signalling pathway .

HY-N7255

Cycloartenol	Structural Classification Microorganisms other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids Cancer	p38 MAPK Apoptosis
Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development .

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