(Rac)-Ketoconazole (Synonyms: (Rac)-Ketoconazol; (Rac)-R 41400)

Cat. No.: HY-W422288: FAQs
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(Rac)-Ketoconazole ((Rac)-R 41400) is an antifungal imidazole compound with oral activity. (Rac)-Ketoconazole interferes with ergosterol synthesis by inhibiting cytochrome P450-dependent 14α-sterol demethylase (CYP51), a key enzyme on the fungal cell membrane, leading to membrane dysfunction and ultimately inhibition of fungal growth and reproduction. (Rac)-Ketoconazole is indicated for studies of fungal infections.

For research use only. We do not sell to patients.

(Rac)-Ketoconazole Chemical Structure

CAS No. : 79156-75-5

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Other Forms of (Rac)-Ketoconazole:

Ketoconazole In-stock
(+)-Ketoconazole In-stock
(-)-Ketoconazole In-stock
(-)-Ketoconazole-d₃ Get quote
Ketoconazole-d₈ Get quote
Ketoconazole-d₄ Get quote

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•Related Small Molecules:

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View All Cytochrome P450 Isoform Specific Products:

View All Isoforms

CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

Biological Activity
Purity & Documentation
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Description	(Rac)-Ketoconazole ((Rac)-R 41400) is an antifungal imidazole compound with oral activity. (Rac)-Ketoconazole interferes with ergosterol synthesis by inhibiting cytochrome P450-dependent 14α-sterol demethylase (CYP51), a key enzyme on the fungal cell membrane, leading to membrane dysfunction and ultimately inhibition of fungal growth and reproduction. (Rac)-Ketoconazole is indicated for studies of fungal infections^[1].
Molecular Weight	531.43
Formula	C₂₆H₂₈Cl₂N₄O₄
CAS No.	79156-75-5
SMILES	CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. Chenge J T, et al. Structural characterization and ligand/inhibitor identification provide functional insights into the Mycobacterium tuberculosis cytochrome P450 CYP126A1[J]. Journal of Biological Chemistry, 2017, 292(4): 1310-1329. [Content Brief]

(Rac)-Ketoconazole Related Classifications

Infection

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-Ketoconazole79156-75-5(Rac)-Ketoconazol (Rac)-R 41400FungalCytochrome P450CYPsAntifungal activitycytochrome P450methylation enzymemembrane functionInhibitorinhibitorinhibit

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