2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Autophagy
  3. Apoptosis Reactive Oxygen Species Autophagy
  4. Daucosterol

Daucosterol  (Synonyms: Eleutheroside A; β-Sitosterol β-D-glucoside)

Cat. No.: HY-N0410 Purity: 93.98%
COA Handling Instructions

Molarity Calculator

Daucosterol is an orally active natural sterol compound, which has anti-inflammatory, anticancer and immunomodulatory activities. Daucosterol inhibits cancer cell proliferation by inducing autophagy through ROS-dependent manner. Daucosterol also inhibits colon cancer growth by inducing apoptosis, inhibiting cell migration and invasion and targeting caspase signalling pathway.

For research use only. We do not sell to patients.

Daucosterol Chemical Structure

Daucosterol Chemical Structure

CAS No. : 474-58-8

Size Price Stock Quantity
1 mg USD 34 In-stock
5 mg USD 84 In-stock
10 mg USD 132 In-stock
25 mg USD 264 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 6 publication(s) in Google Scholar

Daucosterol Related Antibodies

Top Publications Citing Use of Products

    Daucosterol purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2019 Jul 15;855:112-123.  [Abstract]

    Western blot analysis of p53 expression and phosphorylation in DS treated A549 cells with the indicated concentrations after 72 h incubation. DS up-regulates p53 expression and phosphorylation which resulted in activation of downstream regulator p21.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Daucosterol is an orally active natural sterol compound, which has anti-inflammatory, anticancer and immunomodulatory activities. Daucosterol inhibits cancer cell proliferation by inducing autophagy through ROS-dependent manner. Daucosterol also inhibits colon cancer growth by inducing apoptosis, inhibiting cell migration and invasion and targeting caspase signalling pathway[1][2][3].

    In Vitro

    Daucosterol (0.01-100 μM, 48 h) inhibits the proliferation of MCF-7, AGS, MGC803 and BGC823 cells in a dose-dependent manner, with IC50s of 19.96 μM, 3.13 μM, 24.19 μM and 16.95 μM, respectively[1].
    Daucosterol (50 μM, 24 h) significantly increases ROS production in MCF-7 and BGC823 cells[1].
    Daucosterol (0-80 μM, 48 h) inhibits proliferation and promotes apoptosis in PC3 and LNCap cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Daucosterol Related Antibodies

    Western Blot Analysis[2]

    Cell Line: PC3 and LNCap cells
    Concentration: 0-80 μM
    Incubation Time: 48 h
    Result: Increased the expressions of cleaved caspase 3, cleaved caspase 9, Bax protein, LC3II/LC3I ration and Beclin 1.
    Decreased the the expressions of Bax protein and p62.
    In Vivo

    Daucosterol (0.5-2.5 mg/kg, p.o., once per day for 7 days) significantly inhibits the H22 tumor growth in ICR mice inoculated with H22 hepatoma cells[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    576.85

    Formula

    C35H60O6
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    C[C@H](CC[C@@H](CC)C(C)C)[C@](CC1)([H])[C@]2(C)[C@]1([H])[C@]([C@]3([H])CC2)([H])CC=C([C@]3(C)CC4)C[C@H]4O[C@@]5([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O5
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 3.33 mg/mL (5.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7336 mL 8.6678 mL 17.3355 mL
    5 mM 0.3467 mL 1.7336 mL 3.4671 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.7336 mL 8.6678 mL 17.3355 mL 43.3388 mL
    5 mM 0.3467 mL 1.7336 mL 3.4671 mL 8.6678 mL
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Daucosterol Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Daucosterol474-58-8Eleutheroside A β-Sitosterol β-D-glucosideApoptosisReactive Oxygen SpeciesAutophagysterol compoundanti-inflammatoryanticancerimmunomodulatoryapoptosisInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Salutation

    Applicant Name *

    		 

    Email Address *

    Phone Number *

    		 

    Organization Name *

    Department *

    		 

    Requested quantity *

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Daucosterol
    Cat. No.:
    HY-N0410
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.