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superoxide generation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	SOD (1) Apoptosis (1) Elastase (2) Endogenous Metabolite (1) Formyl Peptide Receptor (FPR) (2) Fungal (2) HDAC (1) NF-κB (1) NO Synthase (1) NOD-like Receptor (NLR) (1) Phospholipase (1) Reactive Oxygen Species (9)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (13) Metabolic Disease (3) Neurological Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Targets Recommended: SOD

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N10450

Kumujian A 1-Ethoxycarbonyl-β-carboline	Reactive Oxygen Species	Inflammation/Immunology
Kumujian A (1-Ethoxycarbonyl-β-carboline), an anti-inflammatory agent, inhibits both superoxide anion generation (IC₅₀ = 4.87 μg/mL) and elastase release (IC₅₀ = 6.29 μg/mL) .

HY-154921

Lactosylceramide (bovine buttermilk) LacCer (bovine buttermilk)	Reactive Oxygen Species	Inflammation/Immunology
Lactosylceramide (bovine buttermilk) (LacCer (bovine buttermilk)) is a sphingolipid that highly expressed on the plasma membranes of human phagocytes. Lactosylceramide mediates phagocytosis, chemotaxis, and *superoxide* generation .

HY-N4174

Raddeanoside 20	Reactive Oxygen Species	Metabolic Disease
Raddeanoside 20 is a triterpenoid isolated from the rhizome of Anemone raddeana. Raddeanoside 20 can suppresse superoxide generation .

HY-N11442

Antitumor agent-89	Others	Cancer
Antitumor agent-89 (Compd OTS-5), a natural compound, weakly suppresses fMLP-induced superoxide generation .

HY-N9676

Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside	Others	Others
Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside is a flavonoid compound that can be isolated from Quercus dentata. Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside suppresses the superoxide generation induced by arachidonic acid .

HY-N8217

4-O-Cinnamoylquinic acid	Others	Inflammation/Immunology
4-O-Cinnamoylquinic acid could inhibit superoxide anion generation in human neutrophils .

HY-U00005

AD 0261	Reactive Oxygen Species	Inflammation/Immunology
AD 0261 is a radical scavenger which displays strong inhibitory action on the generation of lipid peroxides and superoxide anions.

HY-156468

Antioxidant agent-17	Others	Inflammation/Immunology
Antioxidant agent-17 (compound 59) is a potent inhibitor of superoxide anion generation activity, with an IC₅₀ of 9.06 nM .

HY-N11564

Aristololactam IIIa	Elastase	Inflammation/Immunology
Aristololactam IIIa exhibits significant inhibitory effects on superoxide anion generation and elastase release with IC₅₀ values of 0.12 and 0.20 μg/mL, respectively .

HY-N8447

3'-O-Methylmurraol	Others	Others
3'-O-Methylmurraol is a coumarinthat can be found in Cnidium monnieri. 3'-O-Methylmurraol inhibits superoxide radical anion generation and elastase release .

HY-126603

Asperlactone	Others	Infection
Asperlactone has anti-inflammatory activity. Asperlactone inhibits superoxide anion generation. Asperlactone is a fungal metabolite that can be isolated from isolated from Aspergillus ochraceus .

HY-N7576

Anemarrhenasaponin Ia	Reactive Oxygen Species	Inflammation/Immunology
Anemarrhenasaponin Ia, isolated from Anemarrhenae rhizome, inhibits N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide generation. Anemarrhenasaponin Ia is an useful anti-inflammation reagent .

HY-132132

Neutrophil elastase inhibitor 3	Elastase	Inflammation/Immunology
Neutrophil elastase inhibitor 3 (compound 13), a benzoxazinone analog, shows effects on superoxide anion generation and exhibits as a neutrophil elastase (NE) inhibitor, with an IC₅₀ of 80.8 nM for NE release .

HY-136651

BNTA	Reactive Oxygen Species	Inflammation/Immunology
BNTA, a potent extracellular matrix (ECM) modulator, facilitates cartilage structural molecule synthesis on chondrocytes by activating superoxide dismutase 3 (SOD3). BNTA shows a promising potential for osteoarthritis alleviation by modulating cartilage generation .

HY-N2100

6'-O-beta-D-Glucosylgentiopicroside	Reactive Oxygen Species	Metabolic Disease
6'-O-beta-D-Glucosylgentiopicroside is a secoiridoid isolated from the roots of G. straminea. 6'-O-beta-D-Glucosylgentiopicroside strongly suppresses N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide generation .

HY-P1119

WRW4 4 Publications Verification	Formyl Peptide Receptor (FPR)	Neurological Disease
WRW4, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC₅₀ of 0.23 μM. WRW4 specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide .

HY-116730

CHS-111	Reactive Oxygen Species	Others
CHS-111 is a benzyl indazole inhibitor of superoxide anion O ^2- generation. CHS-111 inhibits the cell migration, and reduces the formyl-Met-Leu-Phe- but not phorbol ester-stimulated phospholipase D activity, with the IC₅₀ of 3.9 μM .

HY-100581

CORM-3 1 Publications Verification	NF-κB NOD-like Receptor (NLR)	Inflammation/Immunology
CORM-3, a carbon monoxide-releasing molecule, attenuates NF-κB p65 nuclear translocation, reduces ROS generation and enhances intracellular glutathione and superoxide dismutase levels. CORM-3 reduces NLRP3 inflammasome activation .

HY-136855

MitoPBN	Endogenous Metabolite	Metabolic Disease
MitoPBN is a mitochondria-targeted antioxidant. It accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect that is blocked by addition of the mitochondrial membrane potential uncoupler FCCP. MitoPBN inhibits superoxide activation of mitochondrial uncoupling protein 1 (UCP1), UCP2, and UCP3 when used at a concentration of 250 nM in vitro but does not react with superoxide. It traps hydroxyl (IC₅₀=~77 μM) and carbon-centered radicals and inhibits the initiation of lipid peroxidation in isolated bovine heart mitochondria.

HY-19619

m-3M3FBS 5 Publications Verification	Phospholipase Apoptosis	Cancer
m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis .

HY-156241

Meliadubin B	NO Synthase Fungal	Infection Inflammation/Immunology
Meliadubin B is a natural triterpenoid with significant inflammatory inhibition effect toward superoxide anion generation in human neutrophils (EC₅₀ of 5.54 μM). Meliadubin B inhibits *inducible nitric oxide* synthase*. Meliadubin B shows remarkable inhibition against the rice pathogenic fungus Magnaporthe oryzae* with IC₅₀ of 182.50 μM.

HY-124894

(+)-Benalaxyl	Fungal	Infection
(+)-Benalaxyl is a broad-spectrum benzamide fungicide. (+)-Benalaxyl inhibits the growth of the freshwater algae S. obliquus, with an EC₅₀ value of 8.441 mg/L. (+)-Benalaxyl can induce the production of chlorophyll a and b, as well as increase the activity of superoxide dismutase (SOD) and the generation of malondialdehyde (MDA). (+)-Benalaxyl has inhibitory effects on catalase (CAT). (+)-Benalaxyl is effective against diseases caused by oomycetes .

HY-101283

HCH6-1 3 Publications Verification	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
HCH6-1 is a potent and competitive dipeptide antagonist of Formyl peptide receptor 1 (FPR1). HCH6-1 inhibits chemotaxis, superoxide anion generation, and elastase release in human neutrophils specifically activated by fMLF (an FPR1 agonist). HCH6-1 has protective effects against acute lung injury (ALI) in vivo and can be used for the research of FPR1-involved inflammatory lung diseases .

HY-121586

Nafazatrom Bay g 6575	Others	Cardiovascular Disease
Nafazatrom (Bay g 6575) is an orally active cardioprotective agent that protects against ischemic damage. Nafazatrom dose-dependently inhibits neutrophil aggregation, superoxide anion generation, arachidonic acid metabolism, and to a lesser extent the release of β-glucosidase, platelet aggregation or arachidonic acid in vitro. Acid metabolism has no significant effect. In a dog ischemia-reperfusion model, Nafazatrom (10 mg/kg; po) reduced infarct size and the occurrence of arrhythmias and rescued ischemic myocardial function without affecting any hemodynamic changes. The basis of Nafazatrom's cardioprotection may be inhibition of neutrophil function and cellular infiltration in vitro .

HY-158205

HPO-DAEE 4-Hydroperoxy-2-decenoic acid ethyl ester	Reactive Oxygen Species HDAC SOD	Inflammation/Immunology Cancer
HPO-DAEE (4-Hydroperoxy-2-decenoic acid ethyl ester) elicits nuclear accumulation of Nrf2 and activated antioxidant response element (ARE). HPO-DAEE induces antioxidant genes upregulation (eg: HO-1) through Nrf2-ARE signaling. HPO-DAEE induces reactive oxygen species generation. HPO-DAEE also inhibits histone deacetylase and upregulate expression of extracellular superoxide dismutase via histone acetylation. HPO-DAEE protects against 6-hydroxydopamine-induced cell death via activation of Nrf2-ARE and eIF2α-ATF4 pathways .

Cat. No.	Product Name	Type

HY-154921

Lactosylceramide (bovine buttermilk) LacCer (bovine buttermilk)	Cell Assay Reagents
Lactosylceramide (bovine buttermilk) (LacCer (bovine buttermilk)) is a sphingolipid that highly expressed on the plasma membranes of human phagocytes. Lactosylceramide mediates phagocytosis, chemotaxis, and *superoxide* generation .

Cat. No.	Product Name	Target	Research Area

HY-P1119

WRW4 4 Publications Verification	Formyl Peptide Receptor (FPR)	Neurological Disease
WRW4, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC₅₀ of 0.23 μM. WRW4 specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide .

Kumujian A 1-Ethoxycarbonyl-β-carboline	Alkaloids Simaroubaceae Source classification Plants Picrasma quassioides(D．Don)Benn． Indole Alkaloids	Reactive Oxygen Species
Kumujian A (1-Ethoxycarbonyl-β-carboline), an anti-inflammatory agent, inhibits both superoxide anion generation (IC₅₀ = 4.87 μg/mL) and elastase release (IC₅₀ = 6.29 μg/mL) .

6'-O-beta-D-Glucosylgentiopicroside	Structural Classification Iridoids Classification of Application Fields Terpenoids Source classification Gentianaceae Swertia bimaculata (Sieb. et Zucc.) Hook. f. et Thoms. ex C. B. Clark Metabolic Disease Plants Disease Research Fields	Reactive Oxygen Species
6'-O-beta-D-Glucosylgentiopicroside is a secoiridoid isolated from the roots of G. straminea. 6'-O-beta-D-Glucosylgentiopicroside strongly suppresses N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide generation .

Raddeanoside 20	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Ranunculaceae Anemone raddeana Regel Metabolic Disease Plants Disease Research Fields	Reactive Oxygen Species
Raddeanoside 20 is a triterpenoid isolated from the rhizome of Anemone raddeana. Raddeanoside 20 can suppresse superoxide generation .

Antitumor agent-89	Triterpenes Structural Classification Animals Terpenoids Source classification	Others
Antitumor agent-89 (Compd OTS-5), a natural compound, weakly suppresses fMLP-induced superoxide generation .

Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside	Structural Classification Flavonoids Flavones Source classification Quercus dentata Thunb. Plants Fagaceae	Others
Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside is a flavonoid compound that can be isolated from Quercus dentata. Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside suppresses the superoxide generation induced by arachidonic acid .

4-O-Cinnamoylquinic acid	Structural Classification Viscum Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Inflammation/Immunology Disease Research Fields Loranthaceae	Others
4-O-Cinnamoylquinic acid could inhibit superoxide anion generation in human neutrophils .

Aristololactam IIIa	Structural Classification Alkaloids Pyrrole Alkaloids Source classification Aristolochia manshuriensis Kom Plants Aristolochiaceae	Elastase
Aristololactam IIIa exhibits significant inhibitory effects on superoxide anion generation and elastase release with IC₅₀ values of 0.12 and 0.20 μg/mL, respectively .

3'-O-Methylmurraol	Structural Classification Carlina acaulis L. Source classification Coumarins Phenylpropanoids Plants Umbelliferae	Others
3'-O-Methylmurraol is a coumarinthat can be found in Cnidium monnieri. 3'-O-Methylmurraol inhibits superoxide radical anion generation and elastase release .

Anemarrhenasaponin Ia	Structural Classification Liliaceae Classification of Application Fields Source classification Anemarrhena asphodeloides Bunge Plants Inflammation/Immunology Disease Research Fields Steroids	Reactive Oxygen Species
Anemarrhenasaponin Ia, isolated from Anemarrhenae rhizome, inhibits N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide generation. Anemarrhenasaponin Ia is an useful anti-inflammation reagent .

Meliadubin B	Melia dubia Cav. Triterpenes Structural Classification Terpenoids Source classification Plants Meliaceae	NO Synthase Fungal
Meliadubin B is a natural triterpenoid with significant inflammatory inhibition effect toward superoxide anion generation in human neutrophils (EC₅₀ of 5.54 μM). Meliadubin B inhibits *inducible nitric oxide* synthase*. Meliadubin B shows remarkable inhibition against the rice pathogenic fungus Magnaporthe oryzae* with IC₅₀ of 182.50 μM.

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superoxide generation

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Natural
Products