AD 0261

Cat. No.: HY-U00005: FAQs
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AD 0261 is a radical scavenger which displays strong inhibitory action on the generation of lipid peroxides and superoxide anions.

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AD 0261 Chemical Structure

CAS No. : 145600-69-7

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Description	AD 0261 is a radical scavenger which displays strong inhibitory action on the generation of lipid peroxides and superoxide anions.
In Vitro	AD 0261 displays strong inhibitory action on the generation of lipid peroxides (IC₅₀=0.022 μM) and superoxide anions (IC₅₀= 0.9-4.0 μM). AD 0261 inhibits cytokine release and/or production from PHA-P-stimulated lymphocytes in a dose-dependent manner. AD 0261 inhibits all parameters which are indicative of lymphocyte activation with 50% inhibition being achieved in a range of 1-10 μM. AD 0261 suppresses ornithine decarboxylase activity, the IC₅₀ value being around 1.0 μM^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. AD 0261 Related Antibodies
Molecular Weight	451.55
Formula	C₂₇H₃₁F₂N₃O
CAS No.	145600-69-7
SMILES	OC1=CC=C(C)C=C1NCCCN2CCN(C(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)CC2
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (267 KB) Handling Instructions (2659 KB)
References	[1]. M. Sugiura, et al. Effect of the novel radical scavenger AD0261 on lymphocyte activation. Information Research. Agents and Actions. August 1994, Volume 41, Supplement 2, pp C216-C218.

Cell Assay
^[1]

For measurement of [³H]TdR incorporation, cells are incubated for 16 h and additional (6 h) incubation is carried out in the presence of [³H]TdR (0.5 μCi/well). [³H]TdR incorporation is evaluated in a liquid scintillation counter. IL-2 release from lymphocytes is estimated after 20 h incubation by enzyme immunoassay using the commercially available kits. IL-2 receptor expression is quantitated by flow-cytometry using an FITC-labelled monoclonal antibody which recognizes achain of IL-2 receptor complex. Cell viability is determined by either trypan blue exclusion test or propidium iodide staining.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. M. Sugiura, et al. Effect of the novel radical scavenger AD0261 on lymphocyte activation. Information Research. Agents and Actions. August 1994, Volume 41, Supplement 2, pp C216-C218.

AD 0261 Related Classifications

Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AD 0261145600-69-7AD0261AD-0261Reactive Oxygen SpeciesInhibitorinhibitorinhibit

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AD 0261

AD 0261 Related Antibodies

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