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  4. Meliaceae

Meliaceae

 

Meliaceae (103):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-19356
    Rocaglamide 84573-16-0 99.34%
    Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC50 of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia.
    Rocaglamide
  • HY-Y1787
    Dimethyl malonate 108-59-8 99.92%
    Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis.
    Dimethyl malonate
  • HY-N0263
    Toosendanin 58812-37-6 98.77%
    Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities.
    Toosendanin
  • HY-116035
    Nimbolide 25990-37-8 99.79%
    Nimbolide is a triterpene compound that can be isolated from neem (Azadirachta indica), possesses anticancer and antiproliferative activity. Nimbolide induces tumor cell apoptosis by inhibiting NF-κB and CDK4/CDK6 kinase. Nimbolide suppresses the Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways.
    Nimbolide
  • HY-126741
    Azadirachtin 11141-17-6 99.06%
    Azadirachtin is an oral active triterpenoid compound with anticancer, antimalarial, anti-inflammatory, and insecticidal activities. Azadirachtin induces cell apoptosis through the mitochondrial pathway (by inhibiting Bcl-2/Bax ratio or activating Apaf-1 and caspase-3) or through death receptors (by inhibiting TNFR activation). Additionally, Azadirachtin exerts its anti-inflammatory effects by inhibiting NF-кB signaling pathway activation, and it exhibits insecticidal activity by inducing apoptosis in insect cells.
    Azadirachtin
  • HY-N0263R
    Toosendanin (Standard) 58812-37-6
    Toosendanin (Standard) is the analytical standard of Toosendanin. This product is intended for research and analytical applications. Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities.
    Toosendanin (Standard)
  • HY-107296
    1-Acetyltrichilinin 117842-14-5
    1-Acetyltrichilinin is a limonoid that can be isolated from the fruit of Melia toosendan and is a biosynthetic precursor of voltagenin.
    1-Acetyltrichilinin
  • HY-107298
    1-Cinnamoyltrichilinin 117869-72-4
    1-Cinnamoyltrichilinin can inhibit the viability of HL-60 human leukemia cells, induceapoptosis of HL-60 cells, and increase nuclear fragmentation and fractional DNA content by activating the p38 MAPK pathway. The anti-cancer properties of 1-Cinnamoyltrichilinin are only effective against HL-60 cells, not in other human cancer cell lines, such as epidermoid carcinoma (A431), lung epithelial carcinoma (A549), and mammary gland adenocarcinoma (MCF7), at a 20 µM concentration, which is otherwise not toxic to a normal cell line (RAW 264.7). 1-Cinnamoyltrichilinin can be used in the research of leukemia.
    1-Cinnamoyltrichilinin
  • HY-19355
    Rocagloic acid 190385-15-0
    Rocagloic acid is a racaglamide derivative isolated from the fruits of Aglaia elliptifolia with potent cytotoxicity.
    Rocagloic acid
  • HY-N7694
    Isotoosendanin 97871-44-8 99.51%
    Isotoosendanin is a limonoid that can be isolated from Melia toosendan fruit. Isotoosendanin displays significant anti-inflammatory and analgesic activities.
    Isotoosendanin
  • HY-15359
    Episilvestrol 697235-39-5 99.86%
    Episilvestrol is a derivative of silvestrol, isolated from the fruits and twigs of Aglaia perviridis, and is a specific eIF4A-targeting translation inhibitor, with antitumor activity.
    Episilvestrol
  • HY-N1142
    Torachrysone 22649-04-3
    Torachrysone (Nakahalene; Trachrysone), a naphthalene, can be isolated from Cassia tora L.
    Torachrysone
  • HY-N11958
    5-Hydroxy-3,6,7,4'-tetramethoxyflavone 14787-34-9 99.76%
    5-Hydroxy-3,6,7,4'-tetramethoxyflavone is a natural compound isolated from Aglaia edulis.
    5-Hydroxy-3,6,7,4'-tetramethoxyflavone
  • HY-N1281
    Sendanolactone 64929-59-5
    Sendanolactone is a new tetracyclic triterpenoid from the bark of M. azedarach L. var. japonica Makino.
    Sendanolactone
  • HY-N1342
    Rocaglaol 147059-46-9
    Rocaglaol induces apoptosis and cell cycle arrest in LNCaP cells.
    Rocaglaol
  • HY-N3349
    Lyoniresinol 14464-90-5 99.32%
    Lyoniresinol is a lignan isolated from the Tarenna attenuata with antioxidant activities. Lyoniresinol has radical scavenging activities against DPPH with an IC50 of 82.4 μM.
    Lyoniresinol
  • HY-N5104
    Clemaphenol A 362606-60-8 99.77%
    Clemaphenol A is a chemical constituent of the flower of Fritillaria pallidiflora.
    Clemaphenol A
  • HY-W001251
    3,5-Dimethoxybenzoic acid 1132-21-4 99.66%
    3,5-Dimethoxybenzoic acid, isolated from Melia azedarach L. leaves with antifungal activity, is an intermediate in organic synthesis.
    3,5-Dimethoxybenzoic acid
  • HY-N1284
    Seneganolide 301530-12-1
    Seneganolide (compound 1) is isolated from the stem bark of Khaya senegalensis. Seneganolide can be used as insect antifeedant.
    Seneganolide
  • HY-124941
    7-Deacetylgedunin 10314-90-6
    7-Deacetylgedunin is an activator of Keap1/Nrf2/HO-1. 7-Deacetylgedunin alleviates mice mortality induced by LPS. 7-Deacetylgedunin inhibits Keap1 expression and suppresses macrophage proliferation. 7-Deacetylgedunin suppresses inflammation in vivo and in vitro.
    7-Deacetylgedunin