Angiotensin Receptor Antagonist

Angiotensin Receptor Antagonists (107):

Cat. No.	Product Name	Effect	Purity

HY-155041

Antihypertensive agent 2	Antagonist
Antihypertensive agent 2 (Compound 4g) is an antihypertensive agent. Antihypertensive agent 2 has effective antagonistic activities against angiotensin II receptor 1. Antihypertensive agent 2 reduces the blood pressure with equal or more potency compared to Losartan (HY-17512).

HY-146436

AT1R antagonist 2	Antagonist
AT1R antagonist 2 (compound 6) is a potent AT1R selective ligand. AT1R antagonist 2 exhibits a fair AT1R affinity, with a K_i of 26 nM.

HY-B0202R

Irbesartan (Standard)	Antagonist
Irbesartan (Standard) is the analytical standard of Irbesartan. This product is intended for research and analytical applications. Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease.

HY-W414915

Valsartan methyl ester	Antagonist	99.39%
Valsartan methyl ester (Compound 3) is a derivative of Valsartan (HY-18204). Valsartan methyl ester is an orally active antagonist for angiotensin II, that inhibits angiotensin II (IC₅₀ of 0.06 μM), angiotensin II-induced pressor response in rabbit aorta (IC₅₀ of 0.068 μM) and angiotensin II-induced pressor response in the pithed rat model (10% inhibition at 10 mg/kg, p.o.).

HY-19155A

ICI-D 8731	Antagonist
ICI-D 8731 (compound 5g) is a angiotensin II receptor antagonist with the IC₅₀ of 0.031 μM. ICI-D 8731 shows a rapid and sustained lowering of blood pressure in a renal hypertensive rat model.

HY-145552A

Azilsartan mepixetil potassium	Antagonist
Azilsartan mepixetil potassium (QR-01019K) is the antagonist of angiotensin II receptor. Azilsartan mepixetil potassium has stronger and longer blood pressure effect, more abvious and longer lasting heart rate lowering effect and high safety. Azilsartan mepixetil potassium has the potential for the research of hypertension, chronic heart failure and diabetic nephropathy (extracted from patent CN107400122A).

HY-105440

LY 301875	Antagonist
LY 301875 is a potent and orally active angiotensin II receptor type 1 (AT1) antagonist with a pK_B value of 9.6.

HY-114586

L-158809	Antagonist
L-158809 is an angiotensin type 1 (AT1) receptor antagonist that prevents or ameliorates fractionated whole-brain irradiation-induced cognitive impairment. L-158809 is promising for research of brain tumor.

HY-121313

Embusartan	Antagonist
Embusartan (BAY 10-6734) is a brain-penetrant and effective AT1 receptor blocker. Embusartan inhibits Ang II binding to brain AT1 receptors in the nuclei of central nervous system (CNS) inside due to high lipophilic character. Embusartan is promising for research of sympathetic hyperactivity and hypertension.

HY-P10640

[Sar1,Thr8]-Angiotensin II	Antagonist
[Sar1,Thr8]-Angiotensin II is a potent angiotensin II antagonist. [Sar1,Thr8]-Angiotensin II does not alter cardiac performance. [Sar1,Thr8]-Angiotensin II might be safe for patients with cardiac disease.

HY-17512AR

Losartan potassium (Standard)	Antagonist
Losartan (potassium) (Standard) is the analytical standard of Losartan (potassium). This product is intended for research and analytical applications. Losartan potassium (DuP-753 potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC₅₀ of 20 nM.

HY-159090

AT1R antagonist 3	Antagonist
AT1R antagonist 3 (Compound 1) is an antagonist for angiotensin II type 1 receptor (AT1R) and an inhibitor for calcium channel type-L CaV_1.2 (IC₅₀=0.57 μM). AT1R antagonist 3 exhibits vasodilation efficacy in solated rat aorta (10 μM, 88.7%) and antihypertensive efficacy in rat models.

HY-103247

EMD 66684	Antagonist
EMD 66684 is an antagonist of Angiotensin II Type 1 (AT1) receptor. EMD 66684 shows potent binding affinities for the AT1 subtype Ang II receptor with an IC₅₀ value of 0.7 nM. EMD 66684 also serves as an antiischemic cytoprotectant ^-.

HY-155042

Antihypertensive agent 3	Antagonist
Antihypertensive agent 3 (compound 4a) is an antagonis of angiotensin II receptor 1. Antihypertensive agent 3 exhibits antihypertensive activity in a spontaneously hypertensive rats (SHRs) model.

HY-P0205

Saralasin	Antagonist
Saralasin ([Sar1,Ala8] Angiotensin II) is an octapeptide analog of angiotensin II. Saralasin is a competitive angiotensin II receptor antagonist with a K_i value of 0.32 nM for 74% of the binding sites, and has partial agonist activity as well. Saralasin can be used for the research of renovascular hypertension, renin-dependent (angiotensinogenic) hypertension.

HY-78168

Azilsartan methyl ester	Antagonist
Azilsartan methyl ester, a derivative of Azilsartan (HY-14914), is an angiotensin II receptor antagonist that plays an important role in hypertension.

HY-A0250R

Tasosartan (Standard)	Antagonist
Tasosartan (Standard) is the analytical standard of Tasosartan. This product is intended for research and analytical applications. Tasosartan is a long-acting angiotensin II (AngII) receptor antagonist.

HY-17004R

Olmesartan (Standard)	Antagonist
Olmesartan (Standard) is the analytical standard of Olmesartan. This product is intended for research and analytical applications. Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure.

HY-123226

TA-606	Antagonist
TA-606 is a potent and orally active angiotensin II-receptor antagonist. TA-606 shows antihypertensive efficacy. TA-606 can be used for hypertension research.

HY-117805

UR-7247	Antagonist
UR-7247 is a potent and orally active angiotensin II AT1 receptor antagonist. UR-7247 decreases arterial pressure and increases renal blood flow.

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