Valsartan methyl ester (Synonyms: CGP 48933 methyl ester)

Cat. No.: HY-W414915: FAQs
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Valsartan methyl ester (Compound 3) is a derivative of Valsartan (HY-18204). Valsartan methyl ester is an orally active antagonist for angiotensin II, that inhibits angiotensin II (IC₅₀ of 0.06 μM), angiotensin II-induced pressor response in rabbit aorta (IC₅₀ of 0.068 μM) and angiotensin II-induced pressor response in the pithed rat model (10% inhibition at 10 mg/kg, p.o.).

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Valsartan methyl ester Chemical Structure

CAS No. : 137863-17-3

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1 mg	USD 80	Ask For Quote & Lead Time
5 mg	USD 190	Ask For Quote & Lead Time
10 mg	USD 290	Ask For Quote & Lead Time
25 mg	USD 500	Ask For Quote & Lead Time

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Other Forms of Valsartan methyl ester:

Valsartan methyl ester (Standard) Get quote

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Description	Valsartan methyl ester (Compound 3) is a derivative of Valsartan (HY-18204). Valsartan methyl ester is an orally active antagonist for angiotensin II, that inhibits angiotensin II (IC₅₀ of 0.06 μM), angiotensin II-induced pressor response in rabbit aorta (IC₅₀ of 0.068 μM) and angiotensin II-induced pressor response in the pithed rat model (10% inhibition at 10 mg/kg, p.o.)^[1].
Molecular Weight	449.55
Formula	C₂₅H₃₁N₅O₃
CAS No.	137863-17-3
SMILES	COC([C@H](C(C)C)N(C(CCCC)=O)CC1=CC=C(C=C1)C2=C(C3=NN=NN3)C=CC=C2)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (271 KB) Handling Instructions (2659 KB)
References	[1]. Bühlmayer P, et al., Valsartan, a potent, orally active angiotensin II antagonist developed from the structurally new amino acid series[J]. Bioorganic & Medicinal Chemistry Letters, 1994, 4(1): 29-34.

Valsartan methyl ester Related Classifications

Cardiovascular Disease

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Valsartan methyl ester137863-17-3CGP 48933 methyl esterAngiotensin ReceptorHypertensioncongestive heart failureInhibitorinhibitorinhibit

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