2. Signaling Pathways
  3. Immunology/Inflammation
    Metabolic Enzyme/Protease
    NF-κB
  4. Reactive Oxygen Species

Reactive Oxygen Species

Reactive Oxygen Species

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Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-123533S
    Resorufin-d6
    Resorufin-d6 is the deuterium labeled Resorufin. Resorufin (NSC 12097) is a highly fluorescent pink dye for the detection of ROS/RNS and a second analyte[1].
    Resorufin-d<sub>6</sub>
  • HY-12688
    Succinyl phosphonate
    		Inhibitor
    Succinyl phosphonate is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts. Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner. Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ.
    Succinyl phosphonate
  • HY-N12233
    Condurango glycoside A
    		Inducer
    Condurango glycoside A is an activator of p53. Condurango glycoside A initiates ROS generation and up-regulates p53 expression. Condurango glycoside A induces apoptosis and pre-mature senescence associated with DNA damage in HeLa cells.
    Condurango glycoside A
  • HY-10498A
    Lexibulin dihydrochloride
    		Activator
    Lexibulin dihydrochloride (CYT-997 dihydrochloride) is a potent and orally active tubulin polymerisation inhibitor with IC50s of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo. Lexibulin dihydrochloride induces cell apoptosis and induces mitochondrial ROS generation in GC cells.
    Lexibulin dihydrochloride
  • HY-161119
    Drpitor1a
    		Inhibitor
    Drpitor1a is a potent Drp1 inhibitor. Drpitor1a inhibits mitochondrial ROS production, preventes mitochondrial fission, and improves right ventricular diastolic dysfunction during IR (ischemia reperfusion) injury. Drpitor1a has the potential for the research of lung cancer[1]
    Drpitor1a
  • HY-164159
    α-Glucosylrutin
    		Inhibitor
    α-Glucosylrutin is a potent antioxidant with free radical scavenging activity. Due to its high epidermal bioavailability, α-Glucosylrutin can be used in the study of skin aging.
    α-Glucosylrutin
  • HY-12840
    OBA-09
    		99.86%
    OBA-09, a simple ester of pyruvate and salicylic acid, is potent multi-modal neuroprotectant. OBA-09 has anti-oxidative and anti-inflammatory effects.
    OBA-09
  • HY-B0166R
    L-Ascorbic acid (Standard)
    		99.97%
    L-Ascorbic acid (Standard) is the analytical standard of L-Ascorbic acid. This product is intended for research and analytical applications. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells.
    L-Ascorbic acid (Standard)
  • HY-13063
    Sodium formononetin-3'-sulfonate
    		99.79%
    Sodium formononetin-3'-sulfonate (Sul-F) is a water-sol.
    Sodium formononetin-3'-sulfonate
  • HY-B0356AS1
    Ciprofloxacin-13C3,15N monohydrochloride
    		Inducer 99.9%
    Ciprofloxacin-13C3,15N (Bay-09867-13C3,15N) monohydrochloride is 13C- and 15N-labeled Ciprofloxacin (monohydrochloride) (HY-B0356A).
    Ciprofloxacin-<sup>13</sup>C<sub>3</sub>,<sup>15</sup>N monohydrochloride
  • HY-N1408
    trans-Trimethoxyresveratrol
    		99.62%
    Trans-Trimethoxyresveratrol is a derivative of Resveratrol (RSV),and it may be a more potent anti-inflammatory, antiangiogenic and vascular-disrupting agent when compared with resveratrol.
    trans-Trimethoxyresveratrol
  • HY-144876
    RIDR-PI-103
    		Inducer 98.02%
    RIDR-PI-103 is a reactive oxygen species (ROS)-induced drug release prodrug with a self-cyclizing moiety linked to a pan-PI3K inhibitor (PI-103).
    RIDR-PI-103
  • HY-130117
    AlbA-DCA
    		Activator
    AlbA-DCA is a conjugate formed by the attachment of Albiziabioside A (AlbA) to a dichloroacetate acid (DCA) subunit. AlbA-DCA can induce a marked increase in intracellular ROS and alleviate the accumulation of lactic acid in tumor microenvironment (TME), and also selectively kills cancer cells and induce apoptosis.
    AlbA-DCA
  • HY-134769
    OPC-163493
    		Inhibitor
    OPC-163493 is an orally active liver-targeted mitochondrial uncoupling agent. OPC-163493 reduces Δψ and mitochondrial ROS production. OPC-163493 has antidiabetic and cardiovascular beneficial effects. OPC-163493 lowers blood pressure, extends survival, and improves renal function in the rat model of stroke/hypertension.
    OPC-163493
  • HY-N1913A
    Danshensu sodium
    		Inhibitor
    Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu sodium reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu sodium displays a potent antiviral activity against SARS-CoV-2 with EC50 of 0.97 μM. Danshensu sodium has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research.
    Danshensu sodium
  • HY-18085G
    Quercetin (GMP)
    		Inhibitor
    Quercetin GMP is Quercetin (HY-18085) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Quercetin is a flavonoid antioxidant, a PI3K inhibitor and a SIRT1 Activator.
    Quercetin (GMP)
  • HY-147767
    PI3Kα-IN-6
    		Inducer
    PI3Kα-IN-6 (Compound 5b) is a PI3Kα inhibitor. PI3Kα-IN-6 exhibits anticancer potential and no toxicity in normal cells. PI3Kα-IN-6 increases generation of ROS, reduces mitochondrial membrane potential (MMP) and induces apoptosis.
    PI3Kα-IN-6
  • HY-149586
    ROS-IN-2
    		Inhibitor
    ROS-IN-2 (compound 85) is a seco-lupane triterpenoid derivative. ROS-IN-2 blocks ROS production and protects mitochondria from damage by inhibiting excessive production of oxidative stressors. ROS-IN-2 can be used for myocardial ischemia/reperfusion (MI/R) injury research.
    ROS-IN-2
  • HY-142099
    Hispaglabridin A
    		Inhibitor
    Hispaglabridin A is an antioxidant that is effective at inhibiting lipid peroxidation.
    Hispaglabridin A
  • HY-A0169
    Methyl aminolevulinate
    Methyl aminolevulinate is an agent used as a sensitizer in photodynamic therapy (PDT). Methyl aminolevulinate is a proagent that can be metabolized to Protoporphyrin IX.
    Methyl aminolevulinate
Cat. No. Product Name / Synonyms Application Reactivity