2. NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Anti-infection Apoptosis
  3. Keap1-Nrf2 NF-κB Reactive Oxygen Species SARS-CoV Apoptosis
  4. Danshensu sodium

Danshensu sodium  (Synonyms: Dan shen suan A sodium; Salvianic acid A sodium)

Cat. No.: HY-N1913A Purity: 98.00%
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Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu sodium reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu sodium displays a potent antiviral activity against SARS-CoV-2 with EC50 of 0.97 μM. Danshensu sodium has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research.

For research use only. We do not sell to patients.

Danshensu sodium Chemical Structure

Danshensu sodium Chemical Structure

CAS No. : 81075-52-7

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Based on 3 publication(s) in Google Scholar

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Danshensu sodium Related Antibodies

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Description

Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu sodium reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu sodium displays a potent antiviral activity against SARS-CoV-2 with EC50 of 0.97 μM. Danshensu sodium has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research[1][2][3].

In Vitro

Danshensu (Dan shen suan A) sodium potently inhibits the entry of SARS-CoV-2 S protein-pseudo-typed virus (SARS-CoV-2 S) into ACE2-overexpressed HEK-293T cells (IC50=0.31 μM) and Vero-E6 cell (IC50=4.97 μM)[1].
Danshensu (0-100 μM; for 24 h) sodium at higher concentrations (50 and 100 μM) causes significant reduction in migration and invasion of both FaDu and Ca9-22 cells[2].
Danshensu (0-100 μM; for 24 h) sodium dose-dependently reduced the phosphorylation of ERK and p38 phosphorylation in FaDu cell[2].
Danshensu (0-100 μM; for 24, 48, 72 h) sodium does not have any cytotoxic effect on human oral cancer cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Danshensu sodium Related Antibodies

Cell Migration Assay [2]

Cell Line: FaDu and Ca9-22 cells
Concentration: 25, 50, and 100 μM
Incubation Time: 24 h
Result: At higher concentrations (50 and 100 μM) caused significant reduction in migration and invasion of both FaDu and Ca9-22 cells.

Western Blot Analysis[2]

Cell Line: FaDu and Ca9-22 cells
Concentration: 25, 50, and 100 μM
Incubation Time: 24 h
Result: Phosphorylation of ERK reduced dose-dependently after 24 h in FaDu cell.
Caused significant reduction in p38 phosphorylation.
In Vivo

Danshensu (Dan shen suan A; 25, 50, 100 mg/kg; oral administration daily for 7 continuous days or i.v. once) sodium before SARS-CoV-2 S infection dose-dependently alleviates the pathological alterations in mice infected with SARS-CoV-2 S[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult BALB/c mice (male, 6-8 weeks, 20±2 g)[1]
Dosage: 25, 50, 100 mg/kg
Administration: Oral administration (daily for 7 continuous days) or i.v. (once)
Result: Could prevent SARS-CoV-2 S protein-induced acute lung inflammation.
Ameliorated inflammatory cytokines in serum and lung tissue.
Molecular Weight

220.15

Formula

C9H9NaO5
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(O[Na])[C@H](O)CC1=CC(O)=C(C=C1)O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (227.12 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5424 mL 22.7118 mL 45.4236 mL
5 mM 0.9085 mL 4.5424 mL 9.0847 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.00%

SDS (393 KB)

COA (247 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.5424 mL 22.7118 mL 45.4236 mL 113.5589 mL
5 mM 0.9085 mL 4.5424 mL 9.0847 mL 22.7118 mL
10 mM 0.4542 mL 2.2712 mL 4.5424 mL 11.3559 mL
15 mM 0.3028 mL 1.5141 mL 3.0282 mL 7.5706 mL
20 mM 0.2271 mL 1.1356 mL 2.2712 mL 5.6779 mL
25 mM 0.1817 mL 0.9085 mL 1.8169 mL 4.5424 mL
30 mM 0.1514 mL 0.7571 mL 1.5141 mL 3.7853 mL
40 mM 0.1136 mL 0.5678 mL 1.1356 mL 2.8390 mL
50 mM 0.0908 mL 0.4542 mL 0.9085 mL 2.2712 mL
60 mM 0.0757 mL 0.3785 mL 0.7571 mL 1.8926 mL
80 mM 0.0568 mL 0.2839 mL 0.5678 mL 1.4195 mL
100 mM 0.0454 mL 0.2271 mL 0.4542 mL 1.1356 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Danshensu sodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Danshensu81075-52-7Dan shen suan ASalvianic acid AKeap1-Nrf2NF-κBReactive Oxygen SpeciesSARS-CoVApoptosisNuclear factor-κBNuclear factor-kappaBSARS coronavirusOrallyHO-1antioxidant defense mechanismanti-oxidationanti-apoptosislung inflammatoryCOVID-19cardiovascularcerebrovascularInhibitorinhibitorinhibit

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