Danshensu sodium  (Synonyms: Dan shen suan A sodium; Salvianic acid A sodium)

Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu sodium reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu sodium displays a potent antiviral activity against SARS-CoV-2 with EC₅₀ of 0.97 μM. Danshensu sodium has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research^[1][2][3].

Danshensu (Dan shen suan A) sodium potently inhibits the entry of SARS-CoV-2 S protein-pseudo-typed virus (SARS-CoV-2 S) into ACE2-overexpressed HEK-293T cells (IC₅₀=0.31 μM) and Vero-E6 cell (IC₅₀=4.97 μM)^[1].
Danshensu (0-100 μM; for 24 h) sodium at higher concentrations (50 and 100 μM) causes significant reduction in migration and invasion of both FaDu and Ca9-22 cells^[2].
Danshensu (0-100 μM; for 24 h) sodium dose-dependently reduced the phosphorylation of ERK and p38 phosphorylation in FaDu cell^[2].
Danshensu (0-100 μM; for 24, 48, 72 h) sodium does not have any cytotoxic effect on human oral cancer cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Danshensu (Dan shen suan A; 25, 50, 100 mg/kg; oral administration daily for 7 continuous days or i.v. once) sodium before SARS-CoV-2 S infection dose-dependently alleviates the pathological alterations in mice infected with SARS-CoV-2 S^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

220.15

C₉H₉NaO₅

81075-52-7

Solid

Off-white to light yellow

O=C(O[Na])[C@H](O)CC1=CC(O)=C(C=C1)O

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

• [1]. Wei Wang, et al. Danshensu alleviates pseudo-typed SARS-CoV-2 induced mouse acute lung inflammation. Acta Pharmacol Sin. 2022 Apr;43(4):771-780.  [Content Brief]

  [2]. V Bharath Kumar, et al. Sodium Danshensu Inhibits Oral Cancer Cell Migration and Invasion by Modulating p38 Signaling Pathway. Front Endocrinol (Lausanne). 2020 Sep 30:11:568436.  [Content Brief]

  [3]. Chen Yu, et al. Danshensu attenuates cisplatin-induced nephrotoxicity through activation of Nrf2 pathway and inhibition of NF-κB. Biomed Pharmacother. 2021 Oct:142:111995.  [Content Brief]