2. Recombinant Proteins
  3. Immune Checkpoint Proteins
  4. Inhibitory Checkpoint Molecules
  5. TIM-3

TIM-3

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T cell immunoglobulin and mucin-domain containing-3 (TIM-3)，also called HAVCR2, is a co-inhibitory receptor that belongs to the TIM gene family. TIM-3 is a type I trans-membrane protein that was originally discovered as a cell surface marker specific to IFN-γ producing Th1 and Tc1 cells. Hitherto, TIM-3 is detected in different types of immune cells, including T cells, regulatory T cells (Tregs), dendritic cells (DCs), B cells, macrophages, nature killer (NK) cells, and mast cells. Thus far, four distinct ligands for Tim-3 have been reported: galectin-9 (Gal-9), carcinoembryonic antigen cell adhesion molecule 1 (CEACAM-1), high-mobility group protein B1 (HMGB1), and phosphatidylserine (PtdSer). TIM-3 has been shown to mediate immune tolerance and is also associated with immune exhaustion.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P70826
    TIM-3/HAVCR2 Protein, Mouse (HEK293, Fc)

    Hepatitis A virus cellular receptor 2 homolog; HAVcr-2; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; Tim3; Timd3

    		Mouse HEK293
    The TIM-3/HAVCR2 protein is a cell surface receptor that regulates immune responses by inhibiting macrophage activation and suppressing Th1-mediated autoimmunity. TIM-3/HAVCR2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TIM-3/HAVCR2 protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P70482
    TIM-3/HAVCR2 Protein, Human (HEK293, His)

    Hepatitis A Virus Cellular Receptor 2; HAVcr-2; T-Cell Immunoglobulin and Mucin Domain-Containing Protein 3; TIMD-3; T-Cell Membrane Protein 3; TIM-3; HAVCR2; TIM3; TIMD3

    		Human HEK293
    T cell immunoglobulin mucin-3 is an inhibitory receptor, and inhibits T cell functions. TIM-3 regulates immune responses in autoimmunity and cancer. TIM-3 has multiple different ligands: galectin 9, phosphatidylserine (PtdSer), CEACAM1 and HMGB1. The TIM-3-ligand axis is critical in the pathogenesis of numerous conditions, including autoimmune diseases, infections, cancers, transplant rejection, and chronic inflammation. TIM-3/HAVCR2 Protein, Human (HEK293, His) is the recombinant human-derived TIM-3/HAVCR2 protein, expressed by HEK293 , with C-6*His labeled tag.
  • HY-P71995
    TIM-3/HAVCR2 Protein, Mouse (HEK 293, hFc)

    Havcr2; Tim3; Timd3; Hepatitis A virus cellular receptor 2 homolog; HAVcr-2; T-cell immunoglobulin and mucin domain-containing protein 3; TIMD-3; T-cell immunoglobulin mucin receptor 3; TIM-3; T-cell membrane protein 3; CD antigen CD366

    		Mouse HEK293
    The TIM-3/HAVCR2 protein is a cell surface receptor that regulates immune responses by inhibiting macrophage activation and suppressing Th1-mediated autoimmunity. TIM-3/HAVCR2 Protein, Mouse (HEK 293, hFc) is the recombinant mouse-derived TIM-3/HAVCR2 protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P70812
    TIM-3/HAVCR2 Protein, Human (HEK293, Fc-His)

    Hepatitis A virus cellular receptor 2; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell membrane protein 3; FLJ14428; KIM-3; Tim-3; TIM3; TIMD3

    		Human HEK293
    T cell immunoglobulin mucin-3 is an inhibitory receptor, and inhibits T cell functions. TIM-3 regulates immune responses in autoimmunity and cancer. TIM-3 has multiple different ligands: galectin 9, phosphatidylserine (PtdSer), CEACAM1 and HMGB1. The TIM-3-ligand axis is critical in the pathogenesis of numerous conditions, including autoimmune diseases, infections, cancers, transplant rejection, and chronic inflammation. TIM-3/HAVCR2 Protein, Human (HEK293, Fc-His) is the recombinant human-derived TIM-3/HAVCR2 protein, expressed by HEK293 , with C-hFc, C-6*His labeled tag.
  • HY-P78217
    TIM-3/HAVCR2 Protein, Human (Biotinylated, HEK293, His-Avi)

    CD366; TIM3; TIM-3; TIMD-3; TIM 3;  FLJ14428; HAVCR2; KIM3

    		Human HEK293
    The TIM-3/HAVCR2 protein regulates immune responses to pathogens, interacting with LGALS9 on infected macrophages to limit bacterial growth. It enhances CD8+ T cell responses and acts as a phosphatidylserine receptor, mediating phagocytosis of apoptotic cells. TIM-3/HAVCR2 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived TIM-3/HAVCR2 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
  • HY-P7415
    TIM-3/HAVCR2 Protein, Human (HEK293, Fc)

    rHuTIM-3, Fc Chimera; TIMD-3; CD366; HAVCR2

    		Human HEK293
    TIM3 Protein, Human (HEK293, Fc) is a type I transmembrane glycoprotein belonging to T Cell Immunoglobulin Mucin (TIM) family, and is involved in regulating innate and adaptive immunity.
  • HY-P72447
    TIM-3/HAVCR2 Protein, Cynomolgus (HEK293, His)

    Hepatitis A virus cellular receptor 2 homolog; T cell immunoglobulin and mucin domain3; HAVCR2; CD366; TIM3

    		Cynomolgus HEK293
    The TIM-3/HAVCR2 protein is a cell surface receptor that regulates immune responses by inhibiting macrophage activation and suppressing Th1-mediated autoimmunity. TIM-3/HAVCR2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TIM-3/HAVCR2 protein, expressed by HEK293 , with N-8*His labeled tag. The total length of TIM-3/HAVCR2 Protein, Cynomolgus (HEK293, His) is 180 a.a., with molecular weight of 26-30 kDa.
  • HY-P72448
    TIM-3/HAVCR2 Protein, Mouse (HEK293, His)

    Hepatitis A virus cellular receptor 2 homolog; T cell immunoglobulin and mucin domain3; HAVCR2; CD366; TIM3

    		Mouse HEK293
    The TIM-3/HAVCR2 protein is a cell surface receptor that regulates immune responses by inhibiting macrophage activation and suppressing Th1-mediated autoimmunity. TIM-3/HAVCR2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TIM-3/HAVCR2 protein, expressed by HEK293 , with C-6*His labeled tag.
  • HY-P72510
    TIM-3/HAVCR2 Protein, Marmoset (HEK293, His)

    Hepatitis A virus cellular receptor 2 homolog; T cell immunoglobulin and mucin domain3; HAVCR2; CD366; TIM3

    		Marmoset HEK293
    TIM-3/HAVCR2 Protein is a transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important role in the Th1-mediated immune response. TIM-3/HAVCR2 Protein, Marmoset (HEK293, His) is the recombinant Marmoset-derived TIM-3/HAVCR2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TIM-3/HAVCR2 Protein, Marmoset (HEK293, His) is 170 a.a., with molecular weight of 30-45 kDa.
  • HY-P74509
    TIM-3/HAVCR2 Protein, Cynomolgus (HEK293, Fc)

    Hepatitis A virus cellular receptor 2; HAVCR2; CD366; TIM3

    		Cynomolgus HEK293
    TREM-2 Protein binds to DAP10 activates the PI3K signaling pathway. TREM2 signaling leads to downregulated transcription of genes that promote inflammation (Tnf, Il1b, and Nos2), as well as release of cytokines that prevent activation of anti-tumor CD8+ T cells. In addition, it signaling can antagonize TLR expression and signaling, resulting in reduced production of inflammatory cytokines by cultured mouse macrophages. The neuroprotective effects of TREM2 involve not only production of anti-inflammatory cytokines, but also clearance of abnormal proteins and phagocytosis of apoptotic neurons. TIM-3/HAVCR2 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived TIM-3/HAVCR2 protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P72419
    TIM-3/HAVCR2 Protein, Human (Biotinylated, HEK293, Fc-Avi)

    Hepatitis A virus cellular receptor 2; HAVcr-2; TIMD-3; TIM-3; T-cell membrane protein 3; HAVCR2; TIMD3

    		Human HEK293
    T cell immunoglobulin mucin-3 is an inhibitory receptor, and inhibits T cell functions. TIM-3 regulates immune responses in autoimmunity and cancer. TIM-3 has multiple different ligands: galectin 9, phosphatidylserine (PtdSer), CEACAM1 and HMGB1. The TIM-3-ligand axis is critical in the pathogenesis of numerous conditions, including autoimmune diseases, infections, cancers, transplant rejection, and chronic inflammation. TIM-3/HAVCR2 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived TIM-3/HAVCR2 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.
Cat. No. Product Name Effect Purity