2. Signaling Pathways
  3. Immunology/Inflammation
  4. Mucin

Mucin

Mucin is a class of high molecular weight glycoproteins that play crucial roles in protecting and lubricating mucosal surfaces. Mucin is characterized by a large number of O-glycosylated serine and threonine residues. Mucin can be classified into secreted mucins and membrane bounded mucins. For example, MUC1 is often overexpressed in many cancers and can interact with cell surface receptors and extracellular matrix components, affecting cell adhesion, migration and signal transduction. MUC2 is the main component of intestinal mucus, forming a physical barrier to protect the intestinal epithelium from pathogens and toxins. Different mucin subtypes have distinct expression patterns and functions in various tissues and organs. Mucin can also interact with microorganisms, participating in the regulation of the host-microbe interaction[1][2].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P99634
    Gatipotuzumab
    Gatipotuzumab (PankoMab) is a humanized monoclonal antibody which recognizes the tumor-specific epitope of mucin-1 (TA-MUC1). Gatipotuzumab reveals a potent tumor-specific antibody-dependent cell cytotoxicity (ADCC).
    Gatipotuzumab
  • HY-B0264
    Guaifenesin
    		99.82%
    Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough.
    Guaifenesin
  • HY-160109
    Ac5GalNTGc
    		98.39%
    Ac5GalNTGc is a analog of hexosamine. Ac5GalNTGc inhibits mucin-type O-linked glycosylation biosynthesis.
    Ac5GalNTGc
  • HY-P99962
    Surzebiclimab
    Surzebiclimab (BGB-A425) is a humanized IgG1-variant monoclonal antibody against T-cell immunoglobulin and mucin-domain containing-3 (TIM-3). Surzebiclimab binds to the extracellular domain of human Tim-3 with high affinity (KD=0.36 nM) and specificity. Surzebiclimab can be used in research of cancer.
    Surzebiclimab
  • HY-P99732
    Minretumomab
    		Inhibitor
    Minretumomab (CC-49) is a murine monoclonal antibody against TAG-72 (tumor-associated glycoprotein 72). Minretumomab is used in cancer and immunity research.
    Minretumomab
  • HY-168973
    Fexlamose
    		Inhibitor
    Fexlamose is an interventional nebulizer solution with mucolytic property that can be used for researchs of chronic obstructive pulmonary disease COPD.
    Fexlamose
  • HY-171270
    Clivatuzumab-MMAE
    Clivatuzumab-MMAE is an antibody-drug conjugate (ADC) (Clivatuzumab antibody (HY-P99968), Linker: VC linker, Payload: MMAE (HY-15162)). Anetumab is a humanized anti-mucin monoclonal antibody.
    Clivatuzumab-MMAE
  • HY-P2508
    MUC1, mucin core
    		99.85%
    MUC1, mucin core is the region of the MUC1 mucin core. MUC1 is a type I transmembrane glycoprotein, and is overexpressed and aberrantly glycosylated in carcinoma cells. MUC1, mucin core protein binds to domain 1 of ICAM-1.
    MUC1, mucin core
  • HY-P99362
    Ensituximab
    		Inhibitor
    Ensituximab (NEO-102; NPC-1C) is a chimeric monoclonal IgG1 antibody targeting a variant of MUC5AC. Ensituximab shows specificity to colorectal and pancreatic cancer.
    Ensituximab
  • HY-P99591
    Sontuzumab
    		Inhibitor 99.66%
    Sontuzumab (AS1402) is a humanizedised IgG1κ MUC1 specific monoclonal antibody. Sontuzumab binds the extracellular MUC1 peptide sequence PDTR with a Kd of ~1 nM. Sontuzumab can be used for the research of breast cancer.
    Sontuzumab
  • HY-P99968
    Clivatuzumab
    		Inhibitor ≥99.0%
    Clivatuzumab is a humanized anti-mucin monoclonal antibody targeting an epitope in the MUC1 antigen expressed in most pancreatic cancers.
    Clivatuzumab
  • HY-B2206
    Gefarnate
    		≥98.0%
    Gefarnate is a agent used for the treatment of gastritis and gastric ulcer, and has been proposed for use in the treatment of dry eye syndrome.
    Gefarnate
  • HY-P0280
    MUC5AC motif peptide
    		98.79%
    MUC5AC motif peptide is a 16-amino acid fragment of mucin 5.
    MUC5AC motif peptide
  • HY-160109A
    Ac5GalNTGc epimer
    		Inhibitor 98.39%
    Ac5GalNTGc epimer is an analogue of hexosamine and the racemate of Ac5GalNTGc (HY-160109). Ac5GalNTGc inhibits mucin-type O-linked glycosylation biosynthesis.
    Ac5GalNTGc epimer
  • HY-P1925B
    L-GO-203 TFA
    		Inhibitor 98.69%
    L-GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. L-GO-203 TFA is an anti-cancer peptide for targeting intracellular proteins.
    L-GO-203 TFA
  • HY-159702
    Eudragit RS 100
    		Activator
    Eudragit RS 100 is a mucoadhesive, nonbiodegradable positively charged polymer,which can be used for research of developing nanoparticles (NPs) for the ophthalmic and oral administration of Ibuprofen (HY-78131) and Cyclosporins (HY-100731), as well as nano- and micro-fibres used as scaffolds. Eudragit RS 100 NPs interacts efficiently with mucin and promotes glutathione (GSH) transmucosal absorption.
    Eudragit RS 100
  • HY-P990831
    Anti-MUC1/CD227 Antibody (C595 (NCRC48))
    		Inhibitor
    Anti-MUC1/CD227 Antibody (C595 (NCRC48)) is a kind of mouse IgG3, κ chimeric antibody, targeting to human MUC1/CD227. The recommend isotype control of Anti-MUC1/CD227 Antibody (C595 (NCRC48)): Mouse IgG3 kappa, Isotype Control (HY-P99985).
    Anti-MUC1/CD227 Antibody (C595 (NCRC48))
  • HY-136453A
    CR-1-30-B
    		Control 99.92%
    CR-1-30-B is an inactive enantiomer of CR-1-31-B. CR-1-30-B, as a control, is inactive against eIF4A and has no apparent effect on the induction of MUC1-C translation.
    CR-1-30-B
  • HY-158333
    Tasuldine
    		Inhibitor
    Tasuldine is a mucolytic agent, which decreases the sialomucin content of mucus, improves mucociliary and cough clearance.
    Tasuldine
  • HY-160060
    MA3 aptamer sodium
    		Chemical
    MA3 aptamer sodium is an 86-base long DNA aptamer targeting the mucin MUC1. MA3 aptamer sodium binds to the peptide epitope of mucin 1 (MUC1) with a Kd of 38.3 nM and has minimal cross-reactivity with albumin.
    MA3 aptamer sodium
Cat. No. Product Name / Synonyms Application Reactivity