2. Anti-infection
  3. Fungal
  4. Pydiflumetofen

Pydiflumetofen is a new generation of succinate dehydrogenase inhibitor fungicide.

For research use only. We do not sell to patients.

Pydiflumetofen Chemical Structure

Pydiflumetofen Chemical Structure

CAS No. : 1228284-64-7

Size Price Stock Quantity
1 mg USD 390 In-stock
5 mg USD 870 In-stock
10 mg USD 1400 In-stock
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100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Pydiflumetofen Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Pydiflumetofen is a new generation of succinate dehydrogenase inhibitor fungicide[1].

IC50 & Target

Succinate dehydrogenase[1]
In Vitro

Pydiflumetofen (0-4 μg/mL; 3 days) inhibits F. asiaticum mycelial growth and conidium germination[1].
Pydiflumetofen shows no positive or negative cross-resistance with Carbendazim (HY-13582)/phenamacril.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pydiflumetofen Related Antibodies

Cell Viability Assay[1]

Cell Line: Fusarium asiaticum
Concentration: 0, 0.015625, 0.0625, 0.25, 1 and 4 μg/mL
Incubation Time: 3 days
Result: Suppressed mycelial growth with EC50s of 0.019-0.2084 μg/mL and suppressed conidium germination with EC50s of 0.0583-0.4237 μg/mL against 116 isolates of F. asiaticum.
Molecular Weight

426.67

Formula

C16H16Cl3F2N3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C(CC1=C(Cl)C=C(Cl)C=C1Cl)C)OC)C2=CN(C)N=C2C(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (234.37 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3437 mL 11.7187 mL 23.4373 mL
5 mM 0.4687 mL 2.3437 mL 4.6875 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.86 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (5.86 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3437 mL 11.7187 mL 23.4373 mL 58.5933 mL
5 mM 0.4687 mL 2.3437 mL 4.6875 mL 11.7187 mL
10 mM 0.2344 mL 1.1719 mL 2.3437 mL 5.8593 mL
15 mM 0.1562 mL 0.7812 mL 1.5625 mL 3.9062 mL
20 mM 0.1172 mL 0.5859 mL 1.1719 mL 2.9297 mL
25 mM 0.0937 mL 0.4687 mL 0.9375 mL 2.3437 mL
30 mM 0.0781 mL 0.3906 mL 0.7812 mL 1.9531 mL
40 mM 0.0586 mL 0.2930 mL 0.5859 mL 1.4648 mL
50 mM 0.0469 mL 0.2344 mL 0.4687 mL 1.1719 mL
60 mM 0.0391 mL 0.1953 mL 0.3906 mL 0.9766 mL
80 mM 0.0293 mL 0.1465 mL 0.2930 mL 0.7324 mL
100 mM 0.0234 mL 0.1172 mL 0.2344 mL 0.5859 mL
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Pydiflumetofen Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pydiflumetofen1228284-64-7Fungalwheatsuccinate dehydrogenasefungicideFusarium asiaticumInhibitorinhibitorinhibit

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