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Results for "

(±)-U-50488

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

1

Peptides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15997B
    (±)-U-50488 hydrochloride

    (±)-Trans-(1R,2R)-U-50488 hydrochloride

    		 Opioid Receptor Neurological Disease
    (±)-U-50488 ((±)-Trans-(1R,2R)-U-50488) hydrochloride is a selective κ opioid receptor (KOR) agonist .
    (±)-U-50488 hydrochloride
  • HY-15997C
    (±)-U-50488 hydrate hydrochloride

    (±)-Trans-(1R,2R)-U-50488 hydrate hydrochloride

    		 Opioid Receptor Neurological Disease
    (±)-U-50488 ((±)-Trans-(1R,2R)-U-50488) hydrate hydrochloride is a selective κ opioid receptor (KOR) agonist .
    (±)-U-50488 hydrate hydrochloride
  • HY-15997
    (-)-U-50488 hydrochloride

    (-)-Trans-(1S,2S)-U-50488 hydrochloride

    		 Opioid Receptor Infection Cancer
    (-)-U-50488 hydrochloride ((-)-Trans-(1S,2S)-U-50488 hydrochloride) is a selective kappa-opioid receptor (KOR) agonist (b>Kd=2.2 nM) over μ-opioid receptor (MOR) (b>Kd=430 nM). (-)-U-50488 hydrochloride is a more active enantiomer than (+)?trans-(1R,2R) U-50488 (HY-15997A)?or the (±)?trans-racemic mixture U-50488 (HY-15997B). (-)-U-50488 hydrochloride has a potent and sustained anti-HIV effect in fected blood monocyte-derived macrophages (MDM) .
    (-)-U-50488 hydrochloride
  • HY-120949
    (1R,2R)-U-50488 hydrochloride

    		Opioid Receptor Neurological Disease
    (1R,2R)-U-50488 hydrochloride is the absolute stereochemistry of (±)-U-50488 hydrochloride. (±)-U-50488 hydrochloride is a selective κ opioid receptor (KOR) agonist .
    (1R,2R)-U-50488 hydrochloride
  • HY-130696
    (+)-U-50488

    (+)-Trans-(1R,2R)-U-50488

    		 Opioid Receptor Neurological Disease
    (+)-U-50488 ((+)-Trans-(1R,2R)-U-50488) is a less active κ opioid receptor (KOR) agonist than the enantiomer of (-)-Trans-(1S,2S)-U-50488 (HY-15997) .
    (+)-U-50488
  • HY-15997A
    (+)-U-50488 hydrochloride

    (+)-Trans-(1R,2R)-U-50488 hydrochloride

    		 Opioid Receptor Neurological Disease
    (+)-U-50488 (hydrochloride) (+)-Trans-(1R,2R)-U-50488 hydrochloride) is a less active κ opioid receptor (KOR) agonist than the enantiomer of (-)-Trans-(1S,2S)-U-50488 (HY-15997) .
    (+)-U-50488 hydrochloride
  • HY-119733
    BU09059

    		Opioid Receptor Neurological Disease
    BU09059 is a potent and selective Kappa-opioid receptor antagonist with a pA2 of 8.62. BU09059 has nanomolar affinity for the κ-receptor, with 15-fold and 616-fold selectivity over μ- and δ-receptors, respectively. BU09059 significantly blocks U50488 (HY-15997B)-induced antinociception .
    BU09059
  • HY-170342
    KOR agonist 3

    		Opioid Receptor Others
    KOR agonist 3 (Compound 5) is a κ opioid receptor (κOR) agonist with an EC50 of 0.88 nM. KOR agonist 3 also has a certain activation effect on μOR with an EC50 of 720 nM. KOR agonist 3 shows no agonist activity for δOR at concentrations less than 1 μM. KOR agonist 3 has a lower ability to induce the recruitment of β-Arrestin-2 than U50488 (HY-15997B) .
    KOR agonist 3
  • HY-P5756
    CSD-CH2(1,8)-NH2

    		Opioid Receptor Neurological Disease
    CSD-CH2(1,8)-NH2 is a selective and competitive KOR antagonist (Ki: 6.8 nM). CSD-CH2(1,8)-NH2 inhibits calcium mobilization in DRG neurons. CH2(1,8)-NH2 antagonizes the antinociceptive effect of U50,488. CSD-CH2(1,8)-NH2 can be used for research of neuropsychiatric disorders .
    CSD-CH2(1,8)-NH2

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