2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. KOR agonist 3

KOR agonist 3 (Compound 5) is a κ opioid receptor (κOR) agonist with an EC50 of 0.88 nM. KOR agonist 3 also has a certain activation effect on μOR with an EC50 of 720 nM. KOR agonist 3 shows no agonist activity for δOR at concentrations less than 1 μM. KOR agonist 3 has a lower ability to induce the recruitment of β-Arrestin-2 than U50488 (HY-15997B).

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KOR agonist 3 Chemical Structure

KOR agonist 3 Chemical Structure

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KOR agonist 3 Related Antibodies

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Description

KOR agonist 3 (Compound 5) is a κ opioid receptor (κOR) agonist with an EC50 of 0.88 nM. KOR agonist 3 also has a certain activation effect on μOR with an EC50 of 720 nM. KOR agonist 3 shows no agonist activity for δOR at concentrations less than 1 μM. KOR agonist 3 has a lower ability to induce the recruitment of β-Arrestin-2 than U50488 (HY-15997B)[1].

IC50 & Target[1]

κ Opioid Receptor/KOR

0.88 nM (EC50)

μ Opioid Receptor/MOR

720 nM (EC50)

Molecular Weight

388.46

Formula

C24H24N2O3
SMILES

COC(C1=C2[C@]3(CCN(C/4)[C@H]3C[C@H]1C4=C/C)C(C=C(C=C5)C6=COC=C6)=C5N2)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KOR agonist 3 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KOR agonist 3KOR agonist3KOR agonist-3Opioid ReceptorInhibitorinhibitorinhibit

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