2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. (±)-U-50488 hydrochloride

(±)-U-50488 hydrochloride  (Synonyms: (±)-Trans-(1R,2R)-U-50488 hydrochloride)

Cat. No.: HY-15997B Purity: 99.73%
SDS COA Handling Instructions

Molarity Calculator

(±)-U-50488 ((±)-Trans-(1R,2R)-U-50488) hydrochloride is a selective κ opioid receptor (KOR) agonist.

For research use only. We do not sell to patients.

(±)-U-50488 hydrochloride Chemical Structure

(±)-U-50488 hydrochloride Chemical Structure

CAS No. : 67197-96-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
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100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (±)-U-50488 hydrochloride:

(±)-U-50488 hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All Opioid Receptor Isoform Specific Products:

View All Isoforms
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(±)-U-50488 ((±)-Trans-(1R,2R)-U-50488) hydrochloride is a selective κ opioid receptor (KOR) agonist[1].

In Vitro

(±)-U-50488 is a racemic mixture of (+)-Trans-(1R,2R)-U-50488 and (-)-Trans-(1S,2S)-U-50488.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(±)-U-50488 hydrochloride Related Antibodies
Molecular Weight

405.79

Formula

C19H27Cl3N2O
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(N(C)[C@H]1[C@H](N2CCCC2)CCCC1)CC3=CC=C(Cl)C(Cl)=C3.[H]Cl.[Relative stereochemistry]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 116.67 mg/mL (287.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4643 mL 12.3216 mL 24.6433 mL
5 mM 0.4929 mL 2.4643 mL 4.9287 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 5 mg/mL (12.32 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.73%

SDS (393 KB)

COA (258 KB) HNMR (239 KB) RP-HPLC (244 KB) LCMS (258 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4643 mL 12.3216 mL 24.6433 mL 61.6082 mL
5 mM 0.4929 mL 2.4643 mL 4.9287 mL 12.3216 mL
10 mM 0.2464 mL 1.2322 mL 2.4643 mL 6.1608 mL
15 mM 0.1643 mL 0.8214 mL 1.6429 mL 4.1072 mL
20 mM 0.1232 mL 0.6161 mL 1.2322 mL 3.0804 mL
25 mM 0.0986 mL 0.4929 mL 0.9857 mL 2.4643 mL
30 mM 0.0821 mL 0.4107 mL 0.8214 mL 2.0536 mL
40 mM 0.0616 mL 0.3080 mL 0.6161 mL 1.5402 mL
50 mM 0.0493 mL 0.2464 mL 0.4929 mL 1.2322 mL
60 mM 0.0411 mL 0.2054 mL 0.4107 mL 1.0268 mL
80 mM 0.0308 mL 0.1540 mL 0.3080 mL 0.7701 mL
100 mM 0.0246 mL 0.1232 mL 0.2464 mL 0.6161 mL
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(±)-U-50488 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(±)-U-5048867197-96-0(±)-Trans-(1R,2R)-U-50488Opioid Receptorμ-opioid receptorenantiomeranticholinergicracemic mixtureInhibitorinhibitorinhibit

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