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Isoforms Recommended:	ADAM17

Results for "

Adam17

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Bacterial (1) Caspase (1) Fluorescent Dye (4) Interleukin Related (1) MMP (14) Notch (1) Phosphatase (1) Small Interfering RNA (siRNA) (3) TNF Receptor (4)
By Research Areas:	Cancer (9) Cardiovascular Disease (2) Infection (2) Inflammation/Immunology (6) Neurological Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P10174A

ADAM-17 Substrate TFA	Fluorescent Dye MMP	Others
ADAM-17 Substrate is a fluorescent substrate of ADAM .

HY-120852

JG26	MMP	Cancer
JG26 is an *ADAM17* inhibitor, with IC₅₀ values of 12 nM, 1.9 nM, 150 nM and 9.4 nM for ADAM8, ADAM17, ADAM10 and MMP-12, respectively .

HY-115670

GW280264X 3 Publications Verification	MMP	Inflammation/Immunology Cancer
GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and *ADAM10* with IC₅₀s of 8.0 nM and 11.5 nM, respectively . ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells .

HY-12636

INCB3619	MMP Apoptosis	Cancer
INCB3619 is a selective and orally active *ADAM* inhibitor with IC₅₀ of 22 nM and 14 nM for ADAM10 and ADAM17, respectively. INCB3619 has anti-tumor activity .

HY-118694

TAPI-0	TNF Receptor MMP Bacterial	Infection Cancer
TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC₅₀ of 100 nM. TAPI-0 is a MMP inhibitor and also attenuates TNF-α processing .

HY-P10174

ADAM-17 Substrate	Fluorescent Dye MMP	Others
ADAM-17 Substrate is a fluorescent substrate of ADAM .

HY-RS00271

ADAM17 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ADAM17 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM17 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ADAM17 Human Pre-designed siRNA Set A ADAM17 Human Pre-designed siRNA Set A

HY-RS00272

Adam17 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Adam17 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Adam17 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Adam17 Mouse Pre-designed siRNA Set A Adam17 Mouse Pre-designed siRNA Set A

HY-RS00273

Adam17 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Adam17 Rat Pre-designed siRNA Set A contains three designed siRNAs for Adam17 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Adam17 Rat Pre-designed siRNA Set A Adam17 Rat Pre-designed siRNA Set A

HY-110397G

KP-457 (GMP)	MMP	Cardiovascular Disease
KP-457 (GMP) is KP-457 (HY-110397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture.KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC₅₀s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively .

HY-110397

KP-457 3 Publications Verification	MMP	Cardiovascular Disease
KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC₅₀s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively.

HY-16657

TAPI-1 Maximum Cited Publications 7 Publications Verification	MMP	Inflammation/Immunology Cancer
TAPI-1 is a TACE (ADAM17) inhibitor and blocks the shedding of several cell surface proteins . TAPI-1 is also a metalloproteinase (MMP) inhibitor .

HY-19667A

BMS-561392 formate DPC 333 formate	TNF Receptor	Inflammation/Immunology
BMS-561392 formate is the formate form of BMS-561392 (HY-19667). BMS-561392 is a TNF alpha-converting enzyme (TACE) inhibitor. BMS-561392 is also an *ADAM17* blocker. BMS-561392 can be used for research of inflammatory bowel disease .

HY-19667

BMS-561392 DPC 333	TNF Receptor	Inflammation/Immunology
BMS-561392 is a TNF alpha-converting enzyme (TACE) inhibitor. BMS-561392 is also an *ADAM17* blocker. BMS-561392 can be used for research of inflammatory bowel disease .

HY-16657A

(S,S)-TAPI-1	MMP	Inflammation/Immunology Cancer
(S,S)-TAPI-1 is an isomer of TAPI-1. TAPI-1 is a TACE (ADAM17) inhibitor and blocks the shedding of several cell surface proteins. TAPI-1 is also a metalloproteinase (MMP) inhibitor .

HY-10293

Aderbasib INCB007839; INCB7839	MMP	Cancer
Aderbasib (INCB007839) is a potent, orally active and target specific low nanomolar hydroxamate-based inhibitor of *ADAM10* and *ADAM17*. Aderbasib exhibits robust antineoplastic activity and can be used for cancer research, including diffuse large B-cell non-Hodgkin lymphoma, HER2 ⁺ breast cancer, gliomas, et al .

HY-123931

ZLDI-8 1 Publications Verification	Notch Phosphatase Apoptosis	Cancer
ZLDI-8 is a Notch activating/cleaving enzyme *ADAM-17* inhibitor and inhibits the cleavage of Notch protein. ZLDI-8 decreases the expression of pro-survival/anti-apoptosis and epithelial-mesenchymal transition (EMT) related proteins. ZLDI-8 is also a competitive and irreversible tyrosine phosphatase (Lyp) inhibitor with an IC₅₀ of 31.6 μM and a K_i of 26.22 μM. ZLDI-8 inhibits the growth of MHCC97-H cells with an IC₅₀ of 5.32 μM .

HY-P3722

Mca-PLAQAV-Dpa-RSSSR-NH2	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide and as one of fluorescent substrates of TNF-α converting enzyme (TACE; ADAM17), ADAM 9 and ADAM 10. Mca-PLAQAV-Dpa-RSSSR-NH2 is a substrate based on fluorescence resonance energy transfer, and its activity can be determined by the change of fluorescence intensity during pyrolysis .

HY-P3722A

Mca-PLAQAV-Dpa-RSSSR-NH2 TFA	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide and as one of fluorescent substrates of TNF-α converting enzyme (TACE): *ADAM17, ADAM* 9 and ADAM 10. Mca-PLAQAV-Dpa-RSSSR-NH2 is a substrate based on fluorescence resonance energy transfer, and its activity can be determined by the change of fluorescence intensity during pyrolysis .

HY-101448

TMI-1 WAY-171318	MMP Apoptosis Interleukin Related TNF Receptor Caspase	Infection Neurological Disease Inflammation/Immunology Cancer
TMI-1 (WAY-171318) inhibits TNF converting enzyme (TACE) (IC₅₀ of 8.4 nM), *ADAM-TS-4, ADAM-17* and various MMPs with oral activity. TMI-1 significantly suppresses the secretion of TNF-α , alleviating collagen-induced arthritis in mice. TMI-1 inhibits cancer cell proliferation, induces apoptosis through a caspase-dependent pathway. TMI-1 also reverses TRPV1 upregulation and lowers the levels of inflammatory factors (TNF-α、IL-1β、IL-6) in nerve cells, protecting against paclitaxel-induced neurotoxicity. TMI-1 leads to changes in pro-atherogenic lipoprotein profiles, but does not affect the progression of early lesions .

Cat. No.	Product Name	Target	Research Area

HY-P10174A

ADAM-17 Substrate TFA	Fluorescent Dye MMP	Others
ADAM-17 Substrate is a fluorescent substrate of ADAM .

HY-118694

TAPI-0	TNF Receptor MMP Bacterial	Infection Cancer
TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC₅₀ of 100 nM. TAPI-0 is a MMP inhibitor and also attenuates TNF-α processing .

HY-P3722A

Mca-PLAQAV-Dpa-RSSSR-NH2 TFA	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide and as one of fluorescent substrates of TNF-α converting enzyme (TACE): *ADAM17, ADAM* 9 and ADAM 10. Mca-PLAQAV-Dpa-RSSSR-NH2 is a substrate based on fluorescence resonance energy transfer, and its activity can be determined by the change of fluorescence intensity during pyrolysis .

HY-P10174

ADAM-17 Substrate	Fluorescent Dye MMP	Others
ADAM-17 Substrate is a fluorescent substrate of ADAM .

HY-P3722

Mca-PLAQAV-Dpa-RSSSR-NH2	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide and as one of fluorescent substrates of TNF-α converting enzyme (TACE; ADAM17), ADAM 9 and ADAM 10. Mca-PLAQAV-Dpa-RSSSR-NH2 is a substrate based on fluorescence resonance energy transfer, and its activity can be determined by the change of fluorescence intensity during pyrolysis .

Species:	Mouse (1) Rat (1)
Tag:	His (2)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P78717

	ADAM17/TACE Protein, Mouse (HEK293, His) Adam17; TACE; CD156b	Mouse	HEK293
	The ADAM17/TACE protein cleaves TNF-α, releasing it from the membrane and activating various cell surface proteins such as JAM3, ACE2, and the p75 TNF receptor. It also triggers the Notch pathway by cleaving Notch into membrane-associated fragments. ADAM17/TACE Protein, Mouse (HEK293, His) is the recombinant mouse-derived ADAM17/TACE protein, expressed by HEK293 , with C-His labeled tag. The total length of ADAM17/TACE Protein, Mouse (HEK293, His) is 546 a.a..

HY-P72815

	ADAM17/TACE Protein, Rat (HEK293, His) Disintegrin and metalloproteinase domain-containing protein 17; Adam 17; TNF-alpha convertase; CD156b; Tace	Rat	HEK293
	ADAM17/TACE Protein, a pivotal enzyme, cleaves TNF-alpha and activates various cell-surface proteins like p75 TNF-receptor. It also mediates the cleavage of Notch, activates the Notch pathway, and contributes to hemostasis by shedding GP1BA. ADAM17/TACE further facilitates the cleavage of LAG3, IL6R, and FCGR3A, showcasing its significance in diverse cellular functions. ADAM17/TACE Protein, Rat (HEK293, His) is the recombinant rat-derived ADAM17/TACE protein, expressed by HEK293 , with C-10*His labeled tag. The total length of ADAM17/TACE Protein, Rat (HEK293, His) is 546 a.a., with molecular weight of 57 & 20 kDa, respectively.

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HY-P81817

	ADAM17 Antibody (YA1562) CD156b; Adam17; CSVP; TACE	WB, ICC/IF, IP, FC	Human, Mouse, Rat
	ADAM17 Antibody (YA1562) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1562), targeting ADAM17, with a predicted molecular weight of 93 kDa. ADAM17 Antibody (YA1562) can be used for WB, ICC/IF, IP, FC experiment in human, mouse, rat background.

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ADAM17 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
ADAM17 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM17 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Adam17 Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Adam17 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Adam17 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Adam17 Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Adam17 Rat Pre-designed siRNA Set A contains three designed siRNAs for Adam17 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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