2. Apoptosis Metabolic Enzyme/Protease Anti-infection
  3. TNF Receptor MMP Bacterial
  4. TAPI-0

TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC50 of 100 nM. TAPI-0 is a MMP inhibitor and also attenuates TNF-α processing.

For research use only. We do not sell to patients.

TAPI-0 Chemical Structure

TAPI-0 Chemical Structure

CAS No. : 163958-73-4

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1 mg USD 270 In-stock
5 mg USD 770 In-stock
10 mg USD 1240 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of TAPI-0:

TAPI-0 Related Antibodies

Top Publications Citing Use of Products

View All TNF Receptor Isoform Specific Products:

View All Isoforms
TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

View All MMP Isoform Specific Products:

View All Isoforms
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC50 of 100 nM. TAPI-0 is a MMP inhibitor and also attenuates TNF-α processing[1][2].

IC50 & Target

IC50: 100 nM (TACE)[2]
In Vitro

TAPI-0 inhibits peptide deformylase (PDF) with an IC50 of 18 nM. TAPI-0 suppresses chlamydial growth by targeting the bacterial PDF[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TAPI-0 Related Antibodies
Molecular Weight

456.53

Formula

C24H32N4O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ONC(C[C@H](C(N[C@H](C(N[C@H](C(N)=O)C)=O)CC1=CC2=C(C=C1)C=CC=C2)=O)CC(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (109.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1904 mL 10.9522 mL 21.9044 mL
5 mM 0.4381 mL 2.1904 mL 4.3809 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1904 mL 10.9522 mL 21.9044 mL 54.7609 mL
5 mM 0.4381 mL 2.1904 mL 4.3809 mL 10.9522 mL
10 mM 0.2190 mL 1.0952 mL 2.1904 mL 5.4761 mL
15 mM 0.1460 mL 0.7301 mL 1.4603 mL 3.6507 mL
20 mM 0.1095 mL 0.5476 mL 1.0952 mL 2.7380 mL
25 mM 0.0876 mL 0.4381 mL 0.8762 mL 2.1904 mL
30 mM 0.0730 mL 0.3651 mL 0.7301 mL 1.8254 mL
40 mM 0.0548 mL 0.2738 mL 0.5476 mL 1.3690 mL
50 mM 0.0438 mL 0.2190 mL 0.4381 mL 1.0952 mL
60 mM 0.0365 mL 0.1825 mL 0.3651 mL 0.9127 mL
80 mM 0.0274 mL 0.1369 mL 0.2738 mL 0.6845 mL
100 mM 0.0219 mL 0.1095 mL 0.2190 mL 0.5476 mL
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TAPI-0 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAPI-0163958-73-4TAPI0TAPI 0TNF ReceptorMMPBacterialTumor Necrosis Factor ReceptorTNFRMatrix metalloproteinasesTACEADAM17TNF-αpeptide deformylaseInhibitorinhibitorinhibit

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