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Biotransformation,

" in MedChemExpress (MCE) Product Catalog:

24

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1

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1

Peptides

8

Natural
Products

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-I0736
    Isonicotinic acid

    		Drug Metabolite Endogenous Metabolite Others
    Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C .
    Isonicotinic acid
  • HY-P2800
    Diaphorase, Recombinant microorganisms

    		Endogenous Metabolite Others
    Diaphorase, Recombinant microorganisms can be obtained from anaerobic sludge organisms. Diaphorase catalyzes biotransformation of hexahydro-1,3, 5-trinitro-1,3, 5-triazine (RDX) by denitrification .
    Diaphorase, Recombinant microorganisms
  • HY-129217
    Naringinase

    		Glucosidase Others
    Naringinase, a hydrolytic enzymatic complex, possesses the activity of both α-L-rhamnosidase and β-D-glucosidase. Naringinase has wide occurrence in nature. Naringinase can be used in the biotransformation of steroids, antibiotics, and mainly on glycosides hydrolysis .
    Naringinase
  • HY-N8911
    Dihydrodaidzin

    		Endogenous Metabolite Infection
    Dihydrodaidzin is an isoflavanone that can be isolated from Soybeans. Dihydrodaidzin is also a product of biotransformation by human intestinal bacteria .
    Dihydrodaidzin
  • HY-123340
    Ozolinone

    		Endogenous Metabolite Metabolic Disease
    Ozolinone is a diuretic metabolite formed by biotransformation of the diuretic elkapin in mammals and exerts a potent diuretic effect in a variety of species .
    Ozolinone
  • HY-139428
    Hydroxydehydro Nifedipine Carboxylate

    		Others Others
    Hydroxydehydro Nifedipine Carboxylate is an inactive metabolite formed by the oxidative biotransformation of Nifedipine (HY-B0284) in the human body .
    Hydroxydehydro Nifedipine Carboxylate
  • HY-126047
    (S)-(-)-Anatabine

    		Others Others
    (S)-(-)-Anatabine is a Ti plasmid mutant. (S)-(-)-Anatabine has the activity of inducing tobacco blastoma to transform into nicotinic alkaloids. (S)-(-)-Anatabine can be used in the study of biotransformation of cotyl teratoma .
    (S)-(-)-Anatabine
  • HY-N13220
    Soybean Extract

    		Others Endocrinology
    Soybean Extract is a soybean extract, and its components include: Isoflavone. Soybean Extract has an increased content of isoflavone aglycones after biotransformation, which is an estrogen-like bioactive compound with effective type I collagen enhancement. .
    Soybean Extract
  • HY-N11676
    6-Hydroxy-TSU-68

    		Drug Metabolite Cancer
    6-Hydroxy-TSU-68 is a derivative of TSU-68 (HY-10517). It is a metabolite of the biotransformation pathway of TSU-68 in human liver microsomes. The content represents the self-induced hydroxylation level of TSU-68 .
    6-Hydroxy-TSU-68
  • HY-N11677
    7-Hydroxy-TSU-68

    		Drug Metabolite Others
    7-Hydroxy-TSU-68 is a derivative of TSU-68 (HY-10517). It is a metabolite of the biotransformation pathway of TSU-68 in human liver microsomes. The content represents the self-induced hydroxylation level of TSU-68 .
    7-Hydroxy-TSU-68
  • HY-106405
    Nebicapone

    BIA 3-202

    		 COMT Metabolic Disease
    Nebicapone (BIA 3-202), a reversible catechol-O-methyltransferase (COMT) inhibitor, is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to 3-O-methyl-DOPA by inhibition of COMT, and it is potential for the treatment of Parkinson's disease .
    Nebicapone
  • HY-129230
    Triletide

    		Others Cardiovascular Disease
    Triletide is a thromboxane A2 antagonist with good oral absorption activity. The biotransformation of Triletide mainly includes the formation of demethyl, deacetyl, demethyl-deacetyl and hydroxy derivatives. The distribution half-life of Triletide is about 1 hour, and the elimination half-life is about 5 hours .
    Triletide
  • HY-10275A
    Atecegatran TFA

    AR-H067637 TFA

    		 Thrombin Others Cardiovascular Disease
    Atecegatran TFA (AR-H067637 TFA) is an anticoagulant with selective direct thrombin inhibitory activity. Atecegatran TFA is commonly used to inhibit cardiovascular diseases. The biotransformation product of Atecegatran TFA, AR-H067637, is its active form and participates in the anticoagulation process .
    Atecegatran TFA
  • HY-I0736S
    Isonicotinic acid-d4

    		Drug Metabolite Endogenous Metabolite Others
    Isonicotinic acid-d4 is the deuterium labeled Isonicotinic acid[1]. Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C[2].
    Isonicotinic acid-d4
  • HY-19602
    Cedefingol

    		Others Cancer
    Cedefingol is an antitumor compound with α-glucosidase inhibitory activity. Cedefingol was identified together with other compounds in fermented dark tea samples. The biotransformation of cedefingol is related to enzymatic hydrolysis, hydrolysis and biosynthesis. Cedefingol exhibited different bioactivities in samples with different fermentation times. The antioxidant properties of cedefingol showed certain activity in the DPPH model .
    Cedefingol
  • HY-N12033
    4'-Demethylpodophyllotoxone

    		Others Cancer
    4'-Demethylpodophyllotoxone is an intermediate product of the biotransformation of Alternaria alternata S-f6. After 4'-Demethylpodophyllotoxone is modified with 4-(2,3,5,6-tetramethylpyrazine-1) (4-TMP), the resulting novel compound can strongly inhibit the growth of human gastric cancer cell line (BGC-823) .
    4'-Demethylpodophyllotoxone
  • HY-N13078
    3-epi-Resibufogenin

    		Others Cancer
    3-epi-Resibufogenin (compound 2) is an anticancer agent that can be produced by biotransformation of Resibufogenin (HY-N0815) from Actinomucor elegans AS 3.2778. 3-epi-Resibufogenin exhibits cytotoxicity against cancer cells with IC50 values ??of 42.5 μM (A549) and 48.4 μM (H1299), respectively .
    3-epi-Resibufogenin
  • HY-106365A
    Rofleponide epimer

    		Others Inflammation/Immunology
    Rofleponide epimer is a compound with anti-inflammatory activity. Rofleponide epimer has shown high selectivity in the lungs in experiments. Rofleponide epimer exhibits excellent pharmacological properties by efficiently binding to the rat thymic glucocorticoid receptor. The biotransformation rate of Rofleponide epimer is 10 times higher than that of other known similar drugs, indicating that it has potential application value in inhibiting inflammatory diseases involving mucosa .
    Rofleponide epimer
  • HY-N7921
    Urolithin M6

    		Others Others
    Urolithin M6 is a polyhydroxy-rich metabolite with potential antioxidant activity. Urolithin M6 is produced by intestinal microbial metabolism and may act as an analog of tannic acid compounds. The production of Urolithin M6 in humans requires specific bacterial 3-dehydroxylase activity, which provides a new mechanism for its biotransformation. The metabolic profile of Urolithin M6 helps to stratify volunteers and further explore its potential role in health and disease .
    Urolithin M6
  • HY-129878
    N-Trifluoroacetyladriamycin

    AD-41

    		 Others Cancer
    N-Trifluoroacetyladriamycin (AD-41) is a chemotherapeutic compound with antitumor activity. N-Trifluoroacetyladriamycin exhibits the highest fluorescence and radioactivity levels in the small intestine and liver, indicating its significant accumulation in these tissues. N-Trifluoroacetyladriamycin also shows significant accumulation in the kidney, spleen, large intestine, lung, and heart. N-Trifluoroacetyladriamycin is a metabolite of Valrubicin, which is used to inhibit bladder cancer. The presence of N-Trifluoroacetyladriamycin and its derivatives may be related to the biotransformation of the compound and its antitumor mechanism .
    N-Trifluoroacetyladriamycin
  • HY-P2866A
    β-N-Acetylhexosaminidase, Porcine kidney

    NAG, Porcine kidney

    		 Others Others
    β-N-Acetylhexosaminidase, Porcine kidney is a glycosidase with transglycosylation activity, used to generate health-beneficial human milk oligosaccharides, and it effectively interacts with low molecular weight sugar alcohols (such as glycerol, erythritol, and xylitol). The enzyme exhibits optimal activity at pH 5 and 40 °C, and shows high thermal stability (up to 55°C) when bound to the cell wall. β-N-Acetylhexosaminidase holds promise for applications in the biotransformation of Chitin (HY-126389) and research in the food health sector .
    β-N-Acetylhexosaminidase, Porcine kidney
  • HY-124626
    (R)-(+)-Mequitazine

    		Histamine Receptor Inflammation/Immunology
    (R)-(+)-Mequitazine is a histamine H1 receptor antagonist that mainly undergoes bio-transformation via human liver microsomes, resulting in hydroxylated and S-oxidized metabolites. (R)-(+)-Mequitazine competitively binds to the H1 receptors in gastrointestinal, vascular, and respiratory effect cells, thus blocking the endogenous activity of histamine. (R)-(+)-Mequitazine has an inhibitory effect on CYP3A-catalyzed midazolam 1’-hydroxylase. (R)-(+)-Mequitazine can be used in the study of various allergic diseases .
    (R)-(+)-Mequitazine
  • HY-15042
    MK 0686

    		Bradykinin Receptor Metabolic Disease
    MK 0686, a potent bradykinin B1 receptor antagonist, demonstrates autoinduction of metabolism in rhesus monkeys after oral administration. It undergoes significant biotransformation primarily via oxidation pathways, leading to the formation of metabolites like M11 and M13 in rhesus liver microsomes. This metabolic induction is mediated by CYP2C75, as evidenced by increased mRNA expression, protein levels, and catalytic activity of this enzyme in hepatocytes and liver microsomes from MK 0686-treated animals. The autoinduction phenomenon suggests that MK 0686 enhances its own metabolism by upregulating CYP2C75, potentially influencing its systemic exposure and pharmacokinetics over time .
    MK 0686
  • HY-P5740
    Cacaoidin

    		Bacterial Infection
    Cacaoidin is a glycosylated lantibiotic isolated from a Streptomyces cacaoi strain. Cacaoidin has potent antibacterial activity against Gram-positive pathogens including Clostridium difficile .
    Cacaoidin

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