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Results for "

Bitter

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (4) Biochemical Assay Reagents (3) Endogenous Metabolite (1) P-glycoprotein (2) Parasite (1) Taste Receptor (3)
By Research Areas:	Cancer (3) Endocrinology (1) Infection (4) Inflammation/Immunology (5) Metabolic Disease (2) Neurological Disease (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1146

Denatonium benzoate 1 Publications Verification THS-839	Others	Inflammation/Immunology Endocrinology
Denatonium benzoate (THS-839) is known as the most bitter compound and is commonly used as a deterrent (bittering agent) to activate different types of bitter taste receptors (TAS2Rs) with oral activity. Denatonium benzoate can enhance insulin secretion, has anti-inflammatory effects, and promotes allergy susceptibility .

HY-121376

Neoamygdalin	Others	Inflammation/Immunology
Neoamygdalin is a compound identified in the different processed bitter almonds. Neoamygdalin has the potential for the research of cough and asthma .

HY-100047

Nα,Nα-Bis(carboxymethyl)-L-lysine	Taste Receptor	Others
Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC₅₀ of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study .

HY-W009141

1-Monopalmitin Glyceryl palmitate	P-glycoprotein	Cancer
1-Monopalmitin, a bitter melon extract, inhibits the P-glycoprotein (P-gp) activity in intestinal Caco-2 cells .

HY-119309

Sucrose octaacetate	Biochemical Assay Reagents	Others
Sucrose octaacetate is an acetylated derivative of sucrose with an intensely bitter tasting and can be used as bitter tasting surrogate. Sucrose octaacetate can be used as food additive and also used as an adhesive and plasticizer. Sucrose octaacetate also used in many pesticides, insecticides, and other toxic products as a deterrent to accidental poisoning. Sucrose octaacetate can also be used as an in situ seed and a soft template to synthesize polyaniline (PANI) nanofibers .

HY-120735

Lascivol	Others	Others
Lascivol is a bitter compound isolated from Tricholoma species .

HY-121691

Sugereoside	Others	Others
Sugereoside is a bitter diterpene glucoside. Sugereoside can be isolated from leaves of Ilex sugerokii var .

HY-N12718

Campneoside I	Others	Others
Campneoside I is a bitter phenyl propanoid glycoside. Campneoside I can be isolated from the roots of Incarvillea compacta .

HY-W009141R

1-Monopalmitin (Standard)	P-glycoprotein	Cancer
1-Monopalmitin (Standard) is the analytical standard of 1-Monopalmitin. This product is intended for research and analytical applications. 1-Monopalmitin, a bitter melon extract, inhibits the P-glycoprotein (P-gp) activity in intestinal Caco-2 cells .

HY-119309R

Sucrose octaacetate (Standard)	Biochemical Assay Reagents	Others
Sucrose octaacetate (Standard) is the analytical standard of Sucrose octaacetate. This product is intended for research and analytical applications. Sucrose octaacetate is an acetylated derivative of sucrose with an intensely bitter tasting and can be used as bitter tasting surrogate. Sucrose octaacetate can be used as food additive and also used as an adhesive and plasticizer. Sucrose octaacetate also used in many pesticides, insecticides, and other toxic products as a deterrent to accidental poisoning. Sucrose octaacetate can also be used as an in situ seed and a soft template to synthesize polyaniline (PANI) nanofibers .

HY-124956

GIV3727	Taste Receptor	Others
GIV3727 is a bitter taste receptor hTAS2R antagonist, which can inhibit the activation of hTAS2R31 by saccharin and acesulfame potassium, and can effectively reduce the bitter quality of food, beverage and medicine .

HY-N3944

Glaucin B 6β-Acetoxy-5-epilimonin	Others	Others
Glaucin B is a bitter limonoid isolated from the root bark of Evodia glauca .

HY-N13100

Colocynthin	Others	Others
Colocynthin is a cucurbitane triterpenoid glycoside that can be isolated from the bitter apple (Citrullus colocynthis) .

HY-N0742

Absinthin	Others	Others
Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca ²⁺-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46 .

HY-N8290

Lactupicrin Lactucopicrin	Others	Neurological Disease Metabolic Disease
Lactupicrin (Lactucopicrin) is a characteristic bitter sesquiterpene lactone that can relieve pain. Lactupicrin exhibits atheroprotective effect .

HY-N10867

β-Acids colupulone	Others	Others
β-Acids colupulone is the bitter substance. β-Acids colupulone can be isolated from hops .

HY-111070

Karavilagenin D	Others	Cancer
Karavilagenin D, a cucurbitane-type triterpene isolated from Japanese bitter melon leaves, is a potential tumor-promoting inhibitor .

HY-B1146R

Denatonium benzoate (Standard)	Others	Others
Denatonium (benzoate) (Standard) is the analytical standard of Denatonium (benzoate). This product is intended for research and analytical applications. Denatonium benzoate (THS-839) is the most bitter compound known, commonly used as an aversion agent (bitter agent) to prevent inappropriate ingestion, used in denatured alcohol, antifreeze, nail biting prevention, respirator mask fit testing , animal repellents, liquid soaps and shampoos.

HY-N0742R

Absinthin (Standard)	Others	Others
Absinthin (Standard) is the analytical standard of Absinthin. This product is intended for research and analytical applications. Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca2+-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46 .

HY-N13100R

Colocynthin (Standard)	Others	Others
Colocynthin (Standard) is the analytical standard of Colocynthin. This product is intended for research and analytical applications. Colocynthin is a cucurbitane triterpenoid glycoside that can be isolated from the bitter apple (Citrullus colocynthis) .

HY-123026

Salannin	Bacterial	Infection
Salannin, a limonoid bitter principle of the seed oil of Azadirachta indica, shows antiulcer and spermicidal activities. Salannin displays antibacterial activity towards both Gram-positive and Gram-negative bacteria .

HY-N8290R

Lactupicrin (Standard)	Others	Neurological Disease Metabolic Disease
Lactupicrin (Standard) is the analytical standard of Lactupicrin. This product is intended for research and analytical applications. Lactupicrin (Lactucopicrin) is a characteristic bitter sesquiterpene lactone that can relieve pain. Lactupicrin exhibits atheroprotective effect .

HY-Y0585

D-(-)-Mandelic acid 1 Publications Verification	Bacterial	Infection Inflammation/Immunology
D-(-)-Mandelic acid is an orally active alpha hydroxycarboxylic acid that can be isolated from bitter almonds and Indian chestnut trees. It has antioxidant and antibacterial properties and is expected to play an important role in the treatment of rheumatoid arthritis ^[1][4].

HY-N11975

Glycyrrhizin-6′,6′′-dimethylester	Others	Others
Glycyrrhizin-6′,6′′-dimethylester (compound 23) is a licorice saponin isolated from licorice root. Glycyrrhizin-6′,6′′-dimethylester can participate as an aglycone in the generation of methyl glucuronate, producing similar threshold sweetness, licorice, and bitterness .

HY-124257

(R)-Citronellol D-Citronellol; (R)-(+)-β-Citronellol	Endogenous Metabolite	Inflammation/Immunology
(R)-Citronellol (D-Citronellol) is an alcoholic monoterpene found in geranium essential oil. (R)-Citronellol inhibits degranulation of mast cells and does not affect caffeine bitterness perception. (R)-Citronellol can be used in decorative cosmetics, toiletries as well as in non-cosmetic products .

HY-W127447

Maleate trihydrate sodium Maleic acid sodium	Biochemical Assay Reagents	Others
Maleate trihydrate sodiumIt is an organic compound belonging to the salt class. It is formed from the neutralization reaction between maleic acid and sodium hydroxide and has a slightly bitter taste. Maleate trihydrate sodiumIt has a variety of applications in industrial settings, especially as an intermediate in the synthesis of various chemicals and polymers. Additionally, it is used in the food and beverage industry as a buffer, flavor enhancer and preservative.

HY-Y0585R

D-(-)-Mandelic acid (Standard)	Bacterial	Infection Inflammation/Immunology
D-(-)-Mandelic acid (Standard) is the analytical standard of D-(-)-Mandelic acid. This product is intended for research and analytical applications. D-(-)-Mandelic acid is an orally active alpha hydroxycarboxylic acid that can be isolated from bitter almonds and Indian chestnut trees. It has antioxidant and antibacterial properties and is expected to play an important role in the treatment of rheumatoid arthritis .

HY-N11976

Glycyrrhizin-6′′-methylester	Others	Others
Glycyrrhizin-6′′-methylester (compound 22) is a glycyrrhizin that can be isolated from licorice root. Glycyrrhizin-6′′-methylester can participate as an aglycone in the formation of methyl glucuronate, producing a sweet and licorice taste, but no bitterness. This reveals the importance of the free carboxyl group on the glycoside cone-bound glucuronic acid for natural sweetness and licorice taste .

HY-136352

Adenosine 5'-succinate	Taste Receptor	Others
Adenosine 5'-succinate is a chemically AMP-related compound and potently inhibits Denatonium benzoate/taste receptor activation of transducin .

HY-W010607

cis-3-Hexen-1-ol (Z)-3-Hexen-1-ol	Others	Neurological Disease
cis-3-Hexen-1-ol ((Z)-3-Hexen-1-ol) is a green grassy smelling compound found in many fresh fruits and vegetables with bitter taste enhancement. cis-3-Hexen-1-ol is widely used as an added flavor in processed food to provide a fresh green quality. cis-3-Hexen-1-ol is an attractant to various insects .

HY-136429

Ethylhydrocupreine Optochin	Bacterial Parasite	Infection
Ethylhydrocupreine (Optochin) is a quinine derivate with antimicrobial activity against *S. pneumoniae. Ethylhydrocupreine also possesses antimalarial activity against Plasmodium falciparum, with an IC₅₀* of 25.75 nM. Ethylhydrocupreine is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist .

HY-153264

TAS2R14 agonist-1	Others	Others
TAS2R14 agonist is a potent TAS2R14 partial agonist with an EC₅₀ of 116.6 ±23.6 nM .

Cat. No.	Product Name	Type

HY-W127447

Maleate trihydrate sodium Maleic acid sodium	Buffer Reagents
Maleate trihydrate sodiumIt is an organic compound belonging to the salt class. It is formed from the neutralization reaction between maleic acid and sodium hydroxide and has a slightly bitter taste. Maleate trihydrate sodiumIt has a variety of applications in industrial settings, especially as an intermediate in the synthesis of various chemicals and polymers. Additionally, it is used in the food and beverage industry as a buffer, flavor enhancer and preservative.

Maleate trihydrate sodium

Maleic acid sodium

Buffer Reagents

Maleate trihydrate sodiumIt is an organic compound belonging to the salt class. It is formed from the neutralization reaction between maleic acid and sodium hydroxide and has a slightly bitter taste. Maleate trihydrate sodiumIt has a variety of applications in industrial settings, especially as an intermediate in the synthesis of various chemicals and polymers. Additionally, it is used in the food and beverage industry as a buffer, flavor enhancer and preservative.

Cat. No.	Product Name	Target	Research Area

HY-100047

Nα,Nα-Bis(carboxymethyl)-L-lysine	Taste Receptor	Others
Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC₅₀ of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study .

Neoamygdalin	Alkaloids Classification of Application Fields Source classification Rosaceae Plants Prunus armeniaca L. Disease Research Fields Inflammation/Immunology Food Research	Others
Neoamygdalin is a compound identified in the different processed bitter almonds. Neoamygdalin has the potential for the research of cough and asthma .

1-Monopalmitin Glyceryl palmitate	Source classification Plants	P-glycoprotein
1-Monopalmitin, a bitter melon extract, inhibits the P-glycoprotein (P-gp) activity in intestinal Caco-2 cells .

Absinthin	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Other Diseases Plants Acacia confusa Merr. Compositae Disease Research Fields	Others
Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca ²⁺-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46 .

Lactupicrin Lactucopicrin	Structural Classification Monophenols Terpenoids Genista quadriflora Munby Sesquiterpenes Source classification Phenols Plants Compositae	Others
Lactupicrin (Lactucopicrin) is a characteristic bitter sesquiterpene lactone that can relieve pain. Lactupicrin exhibits atheroprotective effect .

Lascivol	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease Research Fields	Others
Lascivol is a bitter compound isolated from Tricholoma species .

Sugereoside	Structural Classification Terpenoids Source classification Diterpenoids Plants Compositae Achillea clypeolata Sm.	Others
Sugereoside is a bitter diterpene glucoside. Sugereoside can be isolated from leaves of Ilex sugerokii var .

Campneoside I	Structural Classification Source classification Phenols Polyphenols Bignoniaceae Plants Incarvillea compacta Maxim.	Others
Campneoside I is a bitter phenyl propanoid glycoside. Campneoside I can be isolated from the roots of Incarvillea compacta .

1-Monopalmitin (Standard)	Source classification Plants	P-glycoprotein
1-Monopalmitin (Standard) is the analytical standard of 1-Monopalmitin. This product is intended for research and analytical applications. 1-Monopalmitin, a bitter melon extract, inhibits the P-glycoprotein (P-gp) activity in intestinal Caco-2 cells .

Glaucin B 6β-Acetoxy-5-epilimonin	Triterpenes Structural Classification Terpenoids Source classification Rutaceae Plants Tetradium ruticarpum (A. Jussieu) T. G. Hartley	Others
Glaucin B is a bitter limonoid isolated from the root bark of Evodia glauca .

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