Absinthin 

Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca²⁺-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46^[1][2][3].

Absinthin (10 μM, 60 s) inhibits histamine-induced Ca²⁺ increases via hTAS2R46 in airway smooth muscle (ASM) cells^[3].
Absinthin (1 and 10 μM, 1 h or 18 h) shows antioxidant activity, and inhibits PMA (HY-18739) induced superoxide anion production (1 h) and iNOS expression (18 h) in BEAS-2B cells^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Absinthin (20-80mg/kg, p.o.) relieves LPS-induced acute lung injury (reduces inflammatory cell infiltration and improves lung architecture) in mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

496.64

C₃₀H₄₀O₆

1362-42-1

Solid

White to off-white

CC1=C[C@@]2([H])[C@]3([H])[C@]1([C@](OC4=O)([H])[C@@]([C@@H]4C)([H])CC[C@@]3(O)C)[C@]5([H])[C@@]2([H])[C@]([C@]6(O)C)([H])C([C@](OC7=O)([H])[C@@]([C@@H]7C)([H])CC6)=C5C

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Zhang W, et al. Total synthesis of absinthin. J Am Chem Soc. 2005 Jan 12;127(1):18-9.  [Content Brief]

  [2]. Lachenmeier DW, et al. Absinthe--a review. Crit Rev Food Sci Nutr. 2006;46(5):365-77.  [Content Brief]

  [3]. Talmon M, et al. Absinthin, an agonist of the bitter taste receptor hTAS2R46, uncovers an ER-to-mitochondria Ca2+-shuttling event. J Biol Chem. 2019 Aug 16;294(33):12472-12482.  [Content Brief]

  [4]. Guo N, et al. Absinthin attenuates LPS-induced ALI through MIP-1α-mediated inflammatory cell infiltration. Exp Lung Res. 2015;41(9):514-24.  [Content Brief]

  [5]. Talmon M, et al. Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells. J Nat Prod. 2020 Jun 26;83(6):1740-1750.  [Content Brief]