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Results for "

COX-2-IN-2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	COX (31) Apoptosis (15) Autophagy (3) Fungal (3) Isotope-Labeled Compounds (3) Lipoxygenase (2) Microtubule/Tubulin (3) NF-κB (2) NOD-like Receptor (NLR) (1) p38 MAPK (3) Phospholipase (1) PPAR (1) Prostaglandin Receptor (1) Reactive Oxygen Species (1) Topoisomerase (1)
By Research Areas:	Cancer (15) Infection (3) Inflammation/Immunology (29)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: COX AIM2 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101655

*COX-2-IN-2*	COX	Inflammation/Immunology
COX-2-IN-2 is a selective and inducible COX2 inhibitor with an IC₅₀ of 0.24 μM. COX-2-IN-1 is an anti-inflammatory compound with anti-inflammatory and analgesic activities.

HY-139578

Ocarocoxib	COX	Inflammation/Immunology
Ocarocoxib, a potent *COX-2 (cyclooxygenase-2)* inhibitor, is a non-steroidal anti-inflammatory for veterinary use .

HY-B0736A

Sertaconazole nitrate 2 Publications Verification FI7056	Fungal Autophagy Apoptosis p38 MAPK Microtubule/Tubulin	Infection Cancer
Sertaconazole nitrate (FI7056) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a *p38-COX-2-PGE2* pathway. Sertaconazole nitrate is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells .

HY-B1130

Isoxicam	COX	Inflammation/Immunology
Isoxicam is an orally active, long-acting, non-steroidal anti-inflammatory agent for the research of arthritis . Isoxicam is a nonselective inhibitor of COX-1 and *COX-2* .

HY-150755

Topo I/COX-2-IN-2	Topoisomerase COX Apoptosis Reactive Oxygen Species	Cancer
Topo I/COX-2-IN-2 (Compound W10) is a potent dual-target inhibitor of Topo I and COX-2 with IC₅₀ values of 0.90 μM and 2.31 μM, respectively. Topo I/COX-2-IN-2 induces cancer cell apoptosis through the mitochondrial pathway .

HY-163188

COX-2/LOX-IN-2	COX Lipoxygenase	Inflammation/Immunology
COX-2/LOX-IN-2 (compound 6) is a dual inhibitor of *COX-2/LOX* with IC₅₀s of 7.0 μM and 27.5 μM, respectively. COX-2/LOX-IN-2 has antioxidant activity and has the potential to be used in the development of nonsteroidal anti-inflammatory drugs (tNSAIDs) .

HY-N11880

2-O-Sinapoyl makisterone A	COX	Cancer
2-O-Sinapoyl makisterone A (compound 2), a sinapinic acid-ecdysterone hybrid, is a selective inhibitor of COX-2. 2-O-Sinapoyl makisterone A significantly inhibits the expression of COX-2 protein .

HY-162228

VI-60	COX Phospholipase	Inflammation/Immunology
VI-60 is a dual, orally active inhibitor of cPLA₂ and COX-2, which reveals an anti-inflammtory efficacy through the inhibition of p38 MAPK/cPLA₂/COX-2/PGE₂ pathway .

HY-B0736

Sertaconazole FI7056 free base	Fungal Autophagy Apoptosis p38 MAPK Microtubule/Tubulin	Infection Inflammation/Immunology Cancer
Sertaconazole (FI7056 free base) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a *p38-COX-2-PGE2* pathway. Sertaconazole is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells .

HY-B0736AR

Sertaconazole nitrate (Standard)	Fungal Autophagy Apoptosis p38 MAPK Microtubule/Tubulin	Infection
Sertaconazole (nitrate) (Standard) is the analytical standard of Sertaconazole (nitrate). This product is intended for research and analytical applications. Sertaconazole nitrate (FI7056) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a p38-COX-2-PGE2 pathway. Sertaconazole nitrate is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells .

HY-145988

COX-2-IN-11	COX	Inflammation/Immunology
COX-2-IN-11 (compound 7b2) is a potent and selective inhibitor of *COX-2*. COX-2-IN-11 has the potential for the research of inflammation diseases .

HY-B0360S

Rebamipide-d4 OPC12759-d₄; Proamipide-d₄	COX Prostaglandin Receptor	Inflammation/Immunology Cancer
Rebamipide-d₄ is deuterium labeled Rebamipide. Rebamipide is a mucoprotective agent. Rebamipide induces COX-2 expression, increases PGE2 levels, and enhances gastric mucosal defense in a COX-2-dependent manner[1].

HY-109158

Rebamipide mofetil	COX	Inflammation/Immunology
Rebamipide mofetil is an orally active proagent of Rebamipide (OPC12759). Rebamipide is a mucoprotective agent. Rebamipide induces COX-2 expression, increases PGE2 levels, and enhances gastric mucosal defense in a COX-2-dependent manner .

HY-B1130R

Isoxicam (Standard)	COX	Inflammation/Immunology
Isoxicam (Standard) is the analytical standard of Isoxicam. This product is intended for research and analytical applications. Isoxicam is an orally active, long-acting, non-steroidal anti-inflammatory agent for the research of arthritis . Isoxicam is a nonselective inhibitor of COX-1 and COX-2 .

HY-B0580S1

Ketorolac-d4	Isotope-Labeled Compounds COX	Inflammation/Immunology
Ketorolac-d₄ (RS37619 D4) is the deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2[1][2].

HY-163187

COX-2/LOX-IN-1	COX Lipoxygenase	Inflammation/Immunology
COX-2/LOX-IN-1 (compound 5) is a dual cyclooxygenase-2/lipoxygenase (COX-2/LOX) inhibitor with IC₅₀s of 30 μM and 0.55 μM, for LOX and COX-2, respectively. .

HY-19384

Enflicoxib E 6087	COX	Inflammation/Immunology
Enflicoxib (E 6087) is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2 (COX-2).?Enflicoxib does not inhibit cyclooxygenase-1 (COX-1). E-6087 shows anti-inflammatory, analgesic and antipyretic activities in animal models .

HY-100516

Cimicoxib UR-8880	COX	Inflammation/Immunology
Cimicoxib (CX) is an orally active potent and selective *COX-2* (cyclo-oxygenase-2) inhibitor. Cimicoxib exhibits promising anti-inflammatory and analgesic activity. The PK parameters of Cimicoxib in dogs given precise (2 mg/kg) and approximate doses (1.95-2.5 mg/kg) are similar .

HY-147748

COX-2-IN-17	COX	Inflammation/Immunology
COX-2-IN-17 (compound 10) is a potent and BBB-penetrated *COX-2* (cyclooxygenase-2) inhibitor, with an IC₅₀ of 0.02 μM. COX-2-IN-17 shows anti-inflammatory and analgesic activities. COX-2-IN-17 attenuates hyperalgesia in the neurogenic phase as well as the inflammatory phase .

HY-147794

COX-2-IN-18	COX	Cancer
COX-2-IN-18 (Compound 3) is a potent inhibitor of *COX-2*. COX-2-IN-18 possesses good COX-2 inhibitory activity (IC₅₀ = 0.775 μM) compared to the reference agent, Celecoxib (IC₅₀ = 0.153 μM). COX-2-IN-18 has the potential for the research of cancer diseases .

HY-161266

COX-2/NLRP3-IN-1	COX NOD-like Receptor (NLR) NF-κB	Inflammation/Immunology
COX-2/NLRP3-IN-1 (Compound 6k) is a COX-2/NLRP3 inhibitor with a IC₅₀ of 1.53 μM for COX-2. COX-2/NLRP3-IN-1 exerts anti-inflammatory effects by inhibiting the NF-κB/NLRP3 signaling pathway .

HY-147692

COX-2-IN-14	COX	Inflammation/Immunology
COX-2-IN-14 (compound 2a) is a potent and selective *COX-2* (cyclooxygenase-2) inhibitor. COX-2-IN-14 shows effective binding at the active site of COX-2 co-crystal. COX-2-IN-14 exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity in mice .

HY-15036

Diclofenac Maximum Cited Publications 16 Publications Verification	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-15038

Diclofenac potassium Maximum Cited Publications 16 Publications Verification	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-15037

Diclofenac Sodium Maximum Cited Publications 16 Publications Verification GP 45840	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-15036A

Diclofenac diethylamine Maximum Cited Publications 16 Publications Verification	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac diethylamine induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-115866

COX-2-IN-6	COX	Cancer
COX-2-IN-6 (compound 10) is an orally active, gut-restricted and selective cyclooxygenase-2 (COX-2) inhibitor for colorectal Chemoprevention of cancer. COX-2-IN-6 selectively targets COX-2 with an IC₅₀ of 0.84 μM and a Ki of 69 nM. COX-2-IN-6 also inhibits COX-2-driven PGE2 synthesis with an IC₅₀ of 0.60 μM .

HY-15037S1

Diclofenac-d4 sodium	COX Apoptosis	Inflammation/Immunology
Diclofenac-d₄ (sodium) is the deuterium labeled Diclofenac sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-15036S

Diclofenac-d4	Isotope-Labeled Compounds COX Apoptosis	Inflammation/Immunology
Diclofenac-d₄ is the deuterium labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-15037R

Diclofenac Sodium (Standard) GP 45840 (Standard)	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac (Sodium) (Standard) is the analytical standard of Diclofenac (Sodium). This product is intended for research and analytical applications. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-15038R

Diclofenac potassium (Standard)	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac (potassium) (Standard) is the analytical standard of Diclofenac (potassium). This product is intended for research and analytical applications. Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-15036R

Diclofenac (Standard)	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac (Standard) is the analytical standard of Diclofenac. This product is intended for research and analytical applications. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-15037S

Diclofenac-13C6 sodium heminonahydrate	Isotope-Labeled Compounds COX Apoptosis	Inflammation/Immunology
Diclofenac- ¹³C₆ (sodium heminonahydrate) is the ¹³C-labeled Diclofenac Sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-15036AR

Diclofenac diethylamine (Standard)	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac (diethylamine) (Standard) is the analytical standard of Diclofenac (diethylamine). This product is intended for research and analytical applications. Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac diethylamine induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-116115

17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid 17-Oxo-DPA; 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-DPA	NF-κB PPAR	Inflammation/Immunology
17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid (17-Oxo-DPA; 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-DPA) is an electrophilic oxo-derivative (EFOX) of the docosahexaenoic acid (DHA) (HY-B2167). 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is generated during inflammation by COX-2-catalyzed mechanism in activated macrophages. 17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid acts as an agonist for PPARγ and a modulator for NF-κB signaling pathway, inhibits the production of pro-inflammatory cytokines and nitric oxide, and exhibits anti-inflammatory efficacy .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N11880

2-O-Sinapoyl makisterone A	Structural Classification Source classification Fibraurea recisa Pierre Plants Menispermaceae Steroids	COX
2-O-Sinapoyl makisterone A (compound 2), a sinapinic acid-ecdysterone hybrid, is a selective inhibitor of COX-2. 2-O-Sinapoyl makisterone A significantly inhibits the expression of COX-2 protein .

Cat. No.	Product Name	Chemical Structure

HY-B0360S

Rebamipide-d4
Rebamipide-d₄ is deuterium labeled Rebamipide. Rebamipide is a mucoprotective agent. Rebamipide induces COX-2 expression, increases PGE2 levels, and enhances gastric mucosal defense in a COX-2-dependent manner[1].

HY-15037S1

Diclofenac-d4 sodium
Diclofenac-d₄ (sodium) is the deuterium labeled Diclofenac sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

Diclofenac-d4 sodium

Diclofenac-d₄ (sodium) is the deuterium labeled Diclofenac sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-15036S

Diclofenac-d4
Diclofenac-d₄ is the deuterium labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-B0580S1

Ketorolac-d4
Ketorolac-d₄ (RS37619 D4) is the deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2[1][2].

HY-15037S

Diclofenac-13C6 sodium heminonahydrate
Diclofenac- ¹³C₆ (sodium heminonahydrate) is the ¹³C-labeled Diclofenac Sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

Diclofenac-13C6 sodium heminonahydrate

Diclofenac- ¹³C₆ (sodium heminonahydrate) is the ¹³C-labeled Diclofenac Sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

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