2. Immunology/Inflammation
  3. COX
  4. COX-2-IN-17

COX-2-IN-17 (compound 10) is a potent and BBB-penetrated COX-2 (cyclooxygenase-2) inhibitor, with an IC50 of 0.02 μM. COX-2-IN-17 shows anti-inflammatory and analgesic activities. COX-2-IN-17 attenuates hyperalgesia in the neurogenic phase as well as the inflammatory phase.

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COX-2-IN-17 Chemical Structure

COX-2-IN-17 Chemical Structure

CAS No. : 2411390-10-6

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COX-2-IN-17 Related Antibodies

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Description

COX-2-IN-17 (compound 10) is a potent and BBB-penetrated COX-2 (cyclooxygenase-2) inhibitor, with an IC50 of 0.02 μM. COX-2-IN-17 shows anti-inflammatory and analgesic activities. COX-2-IN-17 attenuates hyperalgesia in the neurogenic phase as well as the inflammatory phase[1].

IC50 & Target

COX-2

0.02 μM (IC50)

COX-1

>10 μM (IC50)

Molecular Weight

414.89

Formula

C20H23ClN6O2
CAS No.
SMILES

N[C@@H](CC1=CN(C2=NC(Cl)=NC(N3CCCCC3)=N2)C4=CC=CC=C14)C(OC)=O
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Purity & Documentation
References
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COX-2-IN-17 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2-IN-172411390-10-6COXCyclooxygenasetriazine-tryptophan hybridsanti-inflammatorycyclooxygenase-2MDCKInhibitorinhibitorinhibit

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