2. Others Immunology/Inflammation Apoptosis
  3. Isotope-Labeled Compounds COX Apoptosis
  4. Diclofenac-d4

Diclofenac-d4 is the deuterium labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

For research use only. We do not sell to patients.

Diclofenac-d<sub>4</sub> Chemical Structure

Diclofenac-d4 Chemical Structure

CAS No. : 153466-65-0

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Based on 1 publication(s) in Google Scholar

Other Forms of Diclofenac-d4:

Diclofenac-d4 Related Antibodies

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COX COX-1 COX-2 COX-3

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  • Purity & Documentation

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Description

Diclofenac-d4 is the deuterium labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Diclofenac-d4 Related Antibodies
Molecular Weight

300.17

Formula

C14H7D4Cl2NO2
CAS No.
Unlabeled CAS

15307-86-5
Appearance

Solid

Color

White to off-white

SMILES

OC(CC(C([2H])=C([2H])C([2H])=C1[2H])=C1NC2=C(C=CC=C2Cl)Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : ≥ 30 mg/mL (99.94 mM)

DMSO : ≥ 30 mg/mL (99.94 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 30 mg/mL (99.94 mM)

DMSO : ≥ 30 mg/mL (99.94 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3314 mL 16.6572 mL 33.3145 mL
5 mM 0.6663 mL 3.3314 mL 6.6629 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.79%

COA (255 KB) RP-HPLC (342 KB) MS (2103 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO / Ethanol / DMSO 1 mM 3.3314 mL 16.6572 mL 33.3145 mL 83.2861 mL
5 mM 0.6663 mL 3.3314 mL 6.6629 mL 16.6572 mL
10 mM 0.3331 mL 1.6657 mL 3.3314 mL 8.3286 mL
15 mM 0.2221 mL 1.1105 mL 2.2210 mL 5.5524 mL
20 mM 0.1666 mL 0.8329 mL 1.6657 mL 4.1643 mL
25 mM 0.1333 mL 0.6663 mL 1.3326 mL 3.3314 mL
30 mM 0.1110 mL 0.5552 mL 1.1105 mL 2.7762 mL
40 mM 0.0833 mL 0.4164 mL 0.8329 mL 2.0822 mL
50 mM 0.0666 mL 0.3331 mL 0.6663 mL 1.6657 mL
60 mM 0.0555 mL 0.2776 mL 0.5552 mL 1.3881 mL
80 mM 0.0416 mL 0.2082 mL 0.4164 mL 1.0411 mL
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Diclofenac-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diclofenac-d4153466-65-0Isotope-Labeled CompoundsCOXApoptosisCyclooxygenaseInhibitorinhibitorinhibit

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