2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. COX Lipoxygenase
  4. COX-2/LOX-IN-1

COX-2/LOX-IN-1 (compound 5) is a dual cyclooxygenase-2/lipoxygenase (COX-2/LOX) inhibitor with IC50s of 30 μM and 0.55 μM, for LOX and COX-2, respectively. .

For research use only. We do not sell to patients.

COX-2/LOX-IN-1 Chemical Structure

COX-2/LOX-IN-1 Chemical Structure

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COX-2/LOX-IN-1 Related Antibodies

Top Publications Citing Use of Products

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COX COX-1 COX-2 COX-3

View All Lipoxygenase Isoform Specific Products:

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5-LOX 12-LOX 15-LOX

  • Biological Activity

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Description

COX-2/LOX-IN-1 (compound 5) is a dual cyclooxygenase-2/lipoxygenase (COX-2/LOX) inhibitor with IC50s of 30 μM and 0.55 μM, for LOX and COX-2, respectively. [1].

IC50 & Target

COX-2

0.55 μM (IC50)

LOX

30 μM (IC50)

In Vitro

COX-2/LOX-IN-1 (100 μM) reveals an inhibitory activity against lipid peroxidation, the inhibitory percentage is 36%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

COX-2/LOX-IN-1 Related Antibodies
Molecular Weight

446.54

Formula

C30H26N2O2
SMILES

CN(C)C(C=C1)=CC=C1/C=C/C2=CN(C=C2C(C3=CC=CC=C3)=O)C(/C=C/C4=CC=CC=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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COX-2/LOX-IN-1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2/LOX-IN-1COXLipoxygenaseCyclooxygenaseLOXinflammationantioxidantCaco2Inhibitorinhibitorinhibit

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