2. Immunology/Inflammation
  3. COX
  4. Enflicoxib

Enflicoxib (E 6087) is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2 (COX-2).?Enflicoxib does not inhibit cyclooxygenase-1 (COX-1). E-6087 shows anti-inflammatory, analgesic and antipyretic activities in animal models.

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Enflicoxib Chemical Structure

Enflicoxib Chemical Structure

CAS No. : 251442-94-1

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Based on 1 publication(s) in Google Scholar

Enflicoxib Related Antibodies

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Description

Enflicoxib (E 6087) is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2 (COX-2).?Enflicoxib does not inhibit cyclooxygenase-1 (COX-1). E-6087 shows anti-inflammatory, analgesic and antipyretic activities in animal models[1].

IC50 & Target[1]

COX-2

 

In Vivo

E-6132, one of Enflicoxib (E-6087) metabolites, also inhibits COX-2.?After single oral administration of 5 mg/kg of E-6087 to rats, plasma concentrations of Enflicoxib at peak time are higher than those of E-6132, suggesting that activity is mainly due to Enflicoxib[1].
Enflicoxib (E-6087) is characterized by a long elimination half-life (20-35 h), a low plasma clearance (0.10-0.22 L/h/kg) and a relatively large volume of distribution (2-6 L/kg) in rats and dogs after single oral and intravenous doses. Enflicoxib and E-6132 (a pharmacologically active metabolite) show different pharmacokinetics. The higher percentage of Enflicoxib at early times suggests that Enflicoxib is the main compound responsible for in vivo activity, although E-6132 would contribute to the activity at later times[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female Wistar rats (250 g)[1]
Dosage: 5 mg/kg
Administration: Administered by gastric gavage (10 mL/kg); a single oral dose
Result: Plasma concentrations of E-6087 at peak time are higher than those of E-6132.
Molecular Weight

405.34

Formula

C16H12F5N3O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(N2N=C(C(F)(F)F)CC2C3=CC=C(F)C=C3F)C=C1)(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (246.71 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4671 mL 12.3353 mL 24.6706 mL
5 mM 0.4934 mL 2.4671 mL 4.9341 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4671 mL 12.3353 mL 24.6706 mL 61.6766 mL
5 mM 0.4934 mL 2.4671 mL 4.9341 mL 12.3353 mL
10 mM 0.2467 mL 1.2335 mL 2.4671 mL 6.1677 mL
15 mM 0.1645 mL 0.8224 mL 1.6447 mL 4.1118 mL
20 mM 0.1234 mL 0.6168 mL 1.2335 mL 3.0838 mL
25 mM 0.0987 mL 0.4934 mL 0.9868 mL 2.4671 mL
30 mM 0.0822 mL 0.4112 mL 0.8224 mL 2.0559 mL
40 mM 0.0617 mL 0.3084 mL 0.6168 mL 1.5419 mL
50 mM 0.0493 mL 0.2467 mL 0.4934 mL 1.2335 mL
60 mM 0.0411 mL 0.2056 mL 0.4112 mL 1.0279 mL
80 mM 0.0308 mL 0.1542 mL 0.3084 mL 0.7710 mL
100 mM 0.0247 mL 0.1234 mL 0.2467 mL 0.6168 mL
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Enflicoxib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enflicoxib251442-94-1E 6087E6087E-6087COXCyclooxygenaseAnti-inflammatory,nonsteroidalcyclooxygenase-2COX-2Inhibitorinhibitorinhibit

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