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Dolastatin 10

" in MedChemExpress (MCE) Product Catalog:

26

Inhibitors & Agonists

3

Peptides

3

Natural
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2

Isotope-Labeled Compounds

2

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15580
    Dolastatin 10

    DLS 10; NSC 376128

    		 Microtubule/Tubulin ADC Cytotoxin Cancer
    Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization.
    Dolastatin 10
  • HY-15581
    MMAD

    DemethylDolastatin 10; Monomethylauristatin D; Monomethyl Dolastatin 10

    		 Microtubule/Tubulin ADC Cytotoxin Cancer
    MMAD is a potent tubulin inhibitor, is a toxin payload in antibody agent conjugates (ADCs).
    MMAD
  • HY-78828A
    (S)-Dolaphenine hydrochloride

    		Microtubule/Tubulin Others Cancer
    (S)-Dolaphenine hydrochloride is a component of Dolastatin 10 (HY-15580). Dolastatin 10, an antineoplastic agent, inhibits tubulin polymerization .
    (S)-Dolaphenine hydrochloride
  • HY-33046
    N-Boc-dolaproine

    (2R,3R)-BOC-dolaproine

    		 Others Cancer
    N-Boc-dolaproine (Dap) is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .
    N-Boc-dolaproine
  • HY-43304
    N-Boc-dolaproine-methyl

    		Others Cancer
    N-Boc-dolaproine-methyl is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .
    N-Boc-dolaproine-methyl
  • HY-42912A
    N-Boc-dolaproine-OH dicyclohexylamine

    		Others Cancer
    N-Boc-dolaproine-OH dicyclohexylamine is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .
    N-Boc-dolaproine-OH dicyclohexylamine
  • HY-33046A
    N-Boc-dolaproine dicyclohexylamine

    (2R,3R)-BOC-dolaproine dicyclohexylamine

    		 Others Cancer
    N-Boc-dolaproine dicyclohexylamine is an amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity. And contains dicyclohexylamine .
    N-Boc-dolaproine dicyclohexylamine
  • HY-126492
    Vat-Cit-PAB-Monomethyl Dolastatin 10

    		Drug-Linker Conjugates for ADC Cancer
    Vat-Cit-PAB-Monomethyl Dolastatin 10 is a agent-linker conjugate for ADC with potent antitumor activity by using Monomethyl Dolastatin 10 (a potent tubulin inhibitor), linked via the ADC linker Vat-Cit-PAB.
    Vat-Cit-PAB-Monomethyl Dolastatin 10
  • HY-128894
    MC-Sq-Cit-PAB-Dolastatin10

    		Drug-Linker Conjugates for ADC Cancer
    MC-Sq-Cit-PAB-Dolastatin10 is a agent-linker conjugate for ADC with potent antitumor activity by using Dolastatin10 (a tubulin polymerization inhibitor), linked via the ADC linker MC-Sq-Cit-PAB.
    MC-Sq-Cit-PAB-Dolastatin10
  • HY-42912
    N-Boc-dolaproine-OH ((+)-phenylethylamine)

    		Others Cancer
    N-Boc-dolaproine-OH ((+)-phenylethylamine) is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .
    N-Boc-dolaproine-OH ((+)-phenylethylamine)
  • HY-49053
    N-Boc-dolaproine-amide-Me-Phe

    		Others Cancer
    N-Boc-dolaproine-amide-Me-Phe is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .
    N-Boc-dolaproine-amide-Me-Phe
  • HY-78932C
    (2S,3R)-Dap-NE hydrochloride

    		Others Cancer
    (2S,3R)-Dap-NE hydrochloride is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .
    (2S,3R)-Dap-NE hydrochloride
  • HY-78932D
    (2R,3R)-Dap-NE hydrochloride

    		Others Cancer
    (2R,3R)-Dap-NE hydrochloride is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .
    (2R,3R)-Dap-NE hydrochloride
  • HY-139625
    Dolastatinol

    		Microtubule/Tubulin Cancer
    Dolastatinol is a synthetic analog of dolastatin 10 and low nanomolar inhibitor of tubulin polymerization.
    Dolastatinol
  • HY-14672
    Soblidotin
    1 Publications Verification

    Auristatin PE; TZT-1027

    		 Microtubule/Tubulin Cancer
    Soblidotin (Auristatin PE) is a novel synthetic Dolastatin 10 derivative and inhibitor of tubulin polymerization.
    Soblidotin
  • HY-125453
    Symplostatin 1

    		Others Cancer
    Symplostatin 1 is a Dolastatin 10 (HY-15580) analogue that can be isolated from the marine cyanobacterium Symploca hydnoides .
    Symplostatin 1
  • HY-12522S
    PF-06380101-d8
    2 Publications Verification

    Aur0101-d8; Auristatin-0101-d8

    		 Microtubule/Tubulin ADC Cytotoxin Cancer
    PF-06380101-d8 is a deuterium labeled PF-06380101. PF-06380101, an Auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue[1].
    PF-06380101-d8
  • HY-78927
    N-Boc-L-Prolinal

    		Amino Acid Derivatives Others
    N-Boc-L-Prolinal is a proline with a Boc protecting group, which can be used to synthesize biologically active peptide mimetics, such as the synthesis of Dolastatin 10 (HY-15580) analogs with anti-colon cancer activity .
    N-Boc-L-Prolinal
  • HY-15162
    Monomethyl auristatin E
    Maximum Cited Publications
    40 Publications Verification

    MMAE; SGD-1010; Vedotin

    		 Microtubule/Tubulin ADC Cytotoxin Apoptosis Cancer
    Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.
    Monomethyl auristatin E
  • HY-12522
    PF-06380101

    Aur0101; Auristatin-0101

    		 Microtubule/Tubulin ADC Cytotoxin Cancer
    PF-06380101 (Aur0101), an auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue. PF-06380101 (Aur0101) shows excellent potencies in tumor cell proliferation assays and differential ADME properties when compared to other synthetic auristatin analogues that are used in the preparation of ADCs.
    PF-06380101
  • HY-P1126
    Dolastatin 15

    DLS 15

    		 Microtubule/Tubulin ADC Cytotoxin Apoptosis Cancer
    Dolastatin 15 (DLS 15), a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the antitubulin agent Dolastatin 10. Dolastatin 15 induces cell cycle arrest and apoptosis in multiple myeloma cells. Dolastatin 15 can be used as an ADC cytotoxin .
    Dolastatin 15
  • HY-15162R
    Monomethyl auristatin E (Standard)

    MMAE (Standard); SGD-1010 (Standard); Vedotin (Standard)

    		 Microtubule/Tubulin Apoptosis Cancer
    Monomethyl auristatin E (MMAE) (Standard) is the analytical standard of Monomethyl auristatin E (HY-15162). This product is intended for research and analytical applications. Monomethyl auristatin E is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) against several different cancer types .
    Monomethyl auristatin E (Standard)
  • HY-15582
    Auristatin E

    		Microtubule/Tubulin ADC Cytotoxin Cancer
    Auristatin E is a cytotoxic microtubule polymerization inhibitor with potent and selective antitumor activity. Auristatin E is a cytotoxin in antibody-drug conjugates (ADC). Auristatin E inhibits cell division by blocking the polymerisation of tubulin, promising for research in B-cell malignancies. Auristatin E, a synthetic analogue of the Dolastatin 10 (HY-15580), is linear peptides comprised of four amino acids .
    Auristatin E
  • HY-144585
    AGD-0182

    		Microtubule/Tubulin ADC Cytotoxin Others
    AGD-0182 is a microtubule disrupting agent. AGD-0182 is a synthetic analogue of the naturally occurring tubulin-binding molecule Dolastatin 10 . AGD-0182 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    AGD-0182
  • HY-15581S
    MMAD-d8

    DemethylDolastatin 10-d8; Monomethylauristatin D-d8; Monomethyl Dolastatin 10-d8

    		 ADC Cytotoxin Microtubule/Tubulin Cancer
    MMAD-d8D is a deuterated form of MMAD, which is a microtubule disrupting agent.
    MMAD-d8
  • HY-136314
    DBCO-PEG4-VC-PAB-MMAE

    		Drug-Linker Conjugates for ADC Cancer
    DBCO-PEG4-VC-PAB-MMAE consists a ADC linker (DBCO-PEG4-VC-PAB) and a tubulin polymerization inhibitor MMAE (HY-15162). DBCO-PEG4-VC-PAB-MMAE can be used in the synthesis of antibody-agent conjugates (ADCs). MMAE is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. DBCO-PEG4-VC-PAB-MMAE is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG4-VC-PAB-MMAE

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