GAS6

By Targets:	Keap1-Nrf2 (1) NF-κB (1) Small Interfering RNA (siRNA) (1) TAM Receptor (6)
By Research Areas:	Cancer (7) Inflammation/Immunology (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124066

RU-302	TAM Receptor	Cancer
RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC₅₀in cell assays, and suppresses lung cancer tumor growth .

HY-119039

RU-301	TAM Receptor	Inflammation/Immunology Cancer
RU-301 is a pan TAM inhibitor that blocks *Gas6*-induced TAM activation and tumorigenicity. RU-301 significantly reduces nonalcoholic steatohepatitis (NASH) fibrosis, along with attenuates ERK activation and TGFβ1 expression. RU-301 can be used in studies of cancer and nonalcoholic steatohepatitis .

HY-P99463

Batiraxcept AVB-S6-500	TAM Receptor	Cancer
Batiraxcept (AVB-S6-500) is a highly potent and specific AXL inhibitor, a recombinant fusion protein dimer containing the extracellular domain of human AXLM and human immunoglobulin G1 heavy chain (Fc). Batiraxcept binds to *GAS6* and inhibits the interaction of *GAS6* with AXL, thereby substantially reducing AXL signaled invasion and migration of highly metastatic cells in vitro and inhibiting metastatic disease in nonclinical models of aggressive human cancers. Batiraxcept is available for studies in advanced or metastatic clear cell renal cell carcinoma (ccRCC) and platinum sensitive recurrent ovarian cancer .

HY-N2995

Poricoic acid A Poricoic acid A(F)	NF-κB Keap1-Nrf2	Cancer
Poricoic acid A, isolated from Poria cocos, possesses anti-tumor activity . Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis .

HY-P99161

Tilvestamab BGB149	TAM Receptor	Cancer
Tilvestamab (BGB149) is a humanized anti-AXL antibody that blocks AXL-mediated cell signaling. Tilvestamab significantly inhibits *Gas6*-induced AXL activation in 786-0-Luc RCC cells and inhibits downstream AKT phosphorylation. Tilvestamab can be used in cancer research, particularly in AXL overexpressing renal cell carcinomas .

HY-RS05285

GAS6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GAS6 Human Pre-designed siRNA Set A contains three designed siRNAs for GAS6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GAS6 Human Pre-designed siRNA Set A GAS6 Human Pre-designed siRNA Set A

HY-149092

Anticancer agent 109	TAM Receptor	Cancer
Anticancer agent 109 (compound 6-15) is an inhibitor of the *Gas6-Axl* axis with anti-cancer activity. Anticancer agent 109 inhibits the expression of Gas6 and Axl, and the expression p-PI3K and p-AKT in cancer cells, leads to G1 phase arrest and promotes cancer cells apoptosis, and inhibits tumor growth significantly in nude mouse tumor bearing models .

HY-152075

AXL-IN-14	TAM Receptor	Cancer
AXL-IN-14 is a potent and orally active AXL inhibitor with an IC₅₀ value of 0.8 nM. AXL-IN-14 inhibits Gas6/AXL-mediated cell migration and invasion. AXL-IN-14 decreases the expression of p-AXL and p-AKT proteins. AXL-IN-14 shows anti-tumor activity .

Cat. No.	Product Name	Target	Research Area

HY-P99463

Batiraxcept AVB-S6-500	TAM Receptor	Cancer
Batiraxcept (AVB-S6-500) is a highly potent and specific AXL inhibitor, a recombinant fusion protein dimer containing the extracellular domain of human AXLM and human immunoglobulin G1 heavy chain (Fc). Batiraxcept binds to *GAS6* and inhibits the interaction of *GAS6* with AXL, thereby substantially reducing AXL signaled invasion and migration of highly metastatic cells in vitro and inhibiting metastatic disease in nonclinical models of aggressive human cancers. Batiraxcept is available for studies in advanced or metastatic clear cell renal cell carcinoma (ccRCC) and platinum sensitive recurrent ovarian cancer .

HY-P99161

Tilvestamab BGB149	TAM Receptor	Cancer
Tilvestamab (BGB149) is a humanized anti-AXL antibody that blocks AXL-mediated cell signaling. Tilvestamab significantly inhibits *Gas6*-induced AXL activation in 786-0-Luc RCC cells and inhibits downstream AKT phosphorylation. Tilvestamab can be used in cancer research, particularly in AXL overexpressing renal cell carcinomas .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P99463

Batiraxcept AVB-S6-500	Classification of Application Fields Disease Research Fields Cancer	TAM Receptor
Batiraxcept (AVB-S6-500) is a highly potent and specific AXL inhibitor, a recombinant fusion protein dimer containing the extracellular domain of human AXLM and human immunoglobulin G1 heavy chain (Fc). Batiraxcept binds to *GAS6* and inhibits the interaction of *GAS6* with AXL, thereby substantially reducing AXL signaled invasion and migration of highly metastatic cells in vitro and inhibiting metastatic disease in nonclinical models of aggressive human cancers. Batiraxcept is available for studies in advanced or metastatic clear cell renal cell carcinoma (ccRCC) and platinum sensitive recurrent ovarian cancer .

HY-N2995

Poricoic acid A Poricoic acid A(F)	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Polyporaceae Poria cocos Plants Disease Research Fields Cancer	NF-κB Keap1-Nrf2
Poricoic acid A, isolated from Poria cocos, possesses anti-tumor activity . Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis .

HY-P99161

Tilvestamab BGB149	Classification of Application Fields Disease Research Fields Cancer	TAM Receptor
Tilvestamab (BGB149) is a humanized anti-AXL antibody that blocks AXL-mediated cell signaling. Tilvestamab significantly inhibits *Gas6*-induced AXL activation in 786-0-Luc RCC cells and inhibits downstream AKT phosphorylation. Tilvestamab can be used in cancer research, particularly in AXL overexpressing renal cell carcinomas .

Species:	Human (4) Mouse (2) Cynomolgus (1)
Tag:	His (6) Fc (1)
Source:	HEK293 (7)

Cat. No.	Compare	Product Name	Species	Source

HY-P75174

	GAS6 Protein, Mouse (HEK293, His, solution) AXLLG; AXSFAXL receptor tyrosine kinase ligand; GAS-6	Mouse	HEK293
	GAS6 Protein is a vitamin K-dependent protein involved in signaling pathways including GAS6/AXL. The GAS6 Protein contains an NH₂ terminal Gla domain as well as four EGF-like repeats and tandem gl bular domains. GAS6 Protein, Mouse (HEK293, His, solution) is the recombinant mouse-derived GAS6 protein, expressed by HEK293 , with C-His labeled tag.

HY-P70470

	GAS6 Protein, Human (HEK293, Fc) AXLLG; AXLLGAXL stimulatory factor; AXSFAXL receptor tyrosine kinase ligand; GAS6; GAS-6; growth arrest-specific 6; growth arrest-specific protein 6	Human	HEK293
	GAS6 Protein is a secreted protein located outside the cell membrane. GAS6 Protein is a ligand for tyrosine protein kinase receptors AXL, TYRO3, and MER, and its signal transduction is related to cell growth and survival, cell adhesion, and cell migration. GAS6 is associated with tumor cell growth, metastasis, invasion, epithelial mesenchymal transition, angiogenesis, drug resistance, immune regulation, and stem cell maintenance after binding to AXL. GAS6 Protein, Human (HEK293, Fc) is a recombinant GAS6 protein with an Fc tag, expressed by HEK293.

HY-P70780

	GAS6 Protein, Human (HEK293, His, solution) 2 Publications Verification AXLLG; AXLLGAXL stimulatory factor; AXSFAXL receptor tyrosine kinase ligand; GAS6; GAS-6; growth arrest-specific 6; growth arrest-specific protein 6	Human	HEK293
	The GAS6 protein is a ligand for AXL, TYRO3 and MER receptors and affects a variety of cellular processes. GAS6/AXL signaling promotes endothelial cell survival, aids cytokine signaling in natural killer cell development, supports liver regeneration, affects gonadotropin-releasing hormone neuron survival and migration, modulates platelet activation, and regulates thrombotic responses. GAS6 Protein, Mouse (HEK293, His) is the recombinant human-derived GAS6 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P700724

	GAS6 Protein, Human (630a.a, HEK293, His) GAS-6; AXLLG; GAS6; DKFZp666G247; FLJ34709	Human	HEK293
	The GAS6 protein is a ligand for AXL, TYRO3 and MER receptors and affects a variety of cellular processes. GAS6/AXL signaling promotes endothelial cell survival, aids cytokine signaling in natural killer cell development, supports liver regeneration, affects gonadotropin-releasing hormone neuron survival and migration, modulates platelet activation, and regulates thrombotic responses. GAS6 Protein, Human (630a.a, HEK293, His) is the recombinant human-derived GAS6 protein, expressed by HEK293 , with C-His labeled tag. The total length of GAS6 Protein, Human (630a.a, HEK293, His) is 630 a.a., with molecular weight of 71-75 kDa.

HY-P75174A

	GAS6 Protein, Mouse (HEK293, His) AXLLG; AXSFAXL receptor tyrosine kinase ligand; GAS-6	Mouse	HEK293
	GAS6 Protein is a vitamin K-dependent protein involved in signaling pathways including GAS6/AXL. The GAS6 Protein contains an NH₂ terminal Gla domain as well as four EGF-like repeats and tandem gl bular domains. GAS6 Protein, Mouse (674a.a, HEK293, His) is the recombinant mouse-derived GAS6 protein, expressed by HEK293 , with C-His labeled tag.

HY-P70780A

	GAS6 Protein, Human (HEK293, C-His) AXLLG; AXLLGAXL stimulatory factor; AXSFAXL receptor tyrosine kinase ligand; GAS6; GAS-6; growth arrest-specific 6; growth arrest-specific protein 6	Human	HEK293
	The GAS6 protein is a ligand for AXL, TYRO3 and MER receptors and affects a variety of cellular processes.GAS6/AXL signaling promotes endothelial cell survival, aids cytokine signaling in natural killer cell development, supports liver regeneration, affects gonadotropin-releasing hormone neuron survival and migration, modulates platelet activation, and regulates thrombotic responses.GAS6 Protein, Human (HEK293, C-His) is the recombinant human-derived GAS6 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P700723

	GAS6 Protein, Cynomolgus (HEK293, His) GAS-6; AXLLG; GAS6; DKFZp666G247; FLJ34709	Cynomolgus	HEK293
	GAS6 Protein exhibits a deficiency in conserved residue(s) crucial for feature annotation propagation. GAS6 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived GAS6 protein, expressed by HEK293 , with C-His labeled tag. The total length of GAS6 Protein, Cynomolgus (HEK293, His) is 607 a.a., with molecular weight of 69-74 kDa.

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HY-RS05285

GAS6 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
GAS6 Human Pre-designed siRNA Set A contains three designed siRNAs for GAS6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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GAS6

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