Poricoic acid A (Synonyms: Poricoic acid A(F))

Name: Poricoic acid A
Brand: MedChemExpress
SKU: HY-N2995
Rating: 4.5 (1 reviews)

Cat. No.: HY-N2995 Purity: 98.08%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Poricoic acid A, isolated from Poria cocos, possesses anti-tumor activity. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis.

For research use only. We do not sell to patients.

Poricoic acid A Chemical Structure

CAS No. : 137551-38-3

Size	Price	Stock	Quantity
1 mg	USD 128	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 269	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 457	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Poricoic acid A, isolated from Poria cocos, possesses anti-tumor activity^[1]. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 100 μM Compound: 1a	Cytotoxicity in human A549 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity in human A549 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21250700]
AZ-521 cell line	IC₅₀	> 100 μM Compound: 1a	Cytotoxicity in human AZ-521 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity in human AZ-521 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21250700]
CCRF-CEM	IC₅₀	> 40 μM Compound: 22	Antiproliferative activity against human CCRF-CEM cells after 72 hrs by MTT assay Antiproliferative activity against human CCRF-CEM cells after 72 hrs by MTT assay	[PMID: 27808511]
DU-145	IC₅₀	> 100 μM Compound: 1a	Cytotoxicity in human DU145 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity in human DU145 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21250700]
HL-60	IC₅₀	> 40 μM Compound: 22	Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay	[PMID: 27808511]
HL-60	IC₅₀	38 μM Compound: 1a	Cytotoxicity in human HL60 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity in human HL60 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21250700]
HL-60	IC₅₀	38 μM Compound: 7	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 19746919]
K562	IC₅₀	> 40 μM Compound: 22	Antiproliferative activity against human K562 cells after 72 hrs by MTT assay Antiproliferative activity against human K562 cells after 72 hrs by MTT assay	[PMID: 27808511]
MOLT-4	IC₅₀	> 40 μM Compound: 22	Antiproliferative activity against human MOLT4 cells after 72 hrs by MTT assay Antiproliferative activity against human MOLT4 cells after 72 hrs by MTT assay	[PMID: 27808511]
OVCAR-3	IC₅₀	> 100 μM Compound: 1a	Cytotoxicity in human OVCAR3 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity in human OVCAR3 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21250700]
PANC-1	IC₅₀	> 100 μM Compound: 1a	Cytotoxicity in human PANC1 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity in human PANC1 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21250700]
SK-BR-3	IC₅₀	> 100 μM Compound: 1a	Cytotoxicity in human SK-BR-3 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity in human SK-BR-3 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21250700]

Molecular Weight

498.69

Formula

C₃₁H₄₆O₅

CAS No.

137551-38-3

Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@@]([C@]([C@H](C(O)=O)CCC(C(C)C)=C)([H])[C@H](O)C1)(CC=C3C2=CC[C@@H](C(C)=C)[C@]3(C)CCC(O)=O)C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (200.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0053 mL	10.0263 mL	20.0525 mL
5 mM	0.4011 mL	2.0053 mL	4.0105 mL
10 mM	0.2005 mL	1.0026 mL	2.0053 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.01 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.08%

Select Batch:

Data Sheet (270 KB) SDS (251 KB)

COA (247 KB) HNMR (269 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Dong H, et al. Enrichment and separation of antitumor triterpene acids from the epidermis of Poria cocos by pH-zone-refining counter-current chromatography and conventional high-speed counter-current chromatography. J Sep Sci. 2015 Jun;38(11):1977-82. [Content Brief]

[2]. Chen DQ, et al. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis. Free Radic Biol Med. 2019 Apr;134:484-497. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0053 mL	10.0263 mL	20.0525 mL	50.1313 mL
	5 mM	0.4011 mL	2.0053 mL	4.0105 mL	10.0263 mL
	10 mM	0.2005 mL	1.0026 mL	2.0053 mL	5.0131 mL
	15 mM	0.1337 mL	0.6684 mL	1.3368 mL	3.3421 mL
	20 mM	0.1003 mL	0.5013 mL	1.0026 mL	2.5066 mL
	25 mM	0.0802 mL	0.4011 mL	0.8021 mL	2.0053 mL
	30 mM	0.0668 mL	0.3342 mL	0.6684 mL	1.6710 mL
	40 mM	0.0501 mL	0.2507 mL	0.5013 mL	1.2533 mL
	50 mM	0.0401 mL	0.2005 mL	0.4011 mL	1.0026 mL
	60 mM	0.0334 mL	0.1671 mL	0.3342 mL	0.8355 mL
	80 mM	0.0251 mL	0.1253 mL	0.2507 mL	0.6266 mL
	100 mM	0.0201 mL	0.1003 mL	0.2005 mL	0.5013 mL

Poricoic acid A Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Poricoic acid A137551-38-3Poricoic acid A(F)NF-κBKeap1-Nrf2Nuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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Poricoic acid A (Synonyms: Poricoic acid A(F))

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Poricoic acid A Related Antibodies

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References

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Complete Stock Solution Preparation Table

Poricoic acid A Related Classifications

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