2. Protein Tyrosine Kinase/RTK
  3. TAM Receptor
  4. Tilvestamab

Tilvestamab  (Synonyms: BGB149)

Cat. No.: HY-P99161 Purity: 98.08%
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Tilvestamab (BGB149) is a humanized anti-AXL antibody that blocks AXL-mediated cell signaling. Tilvestamab significantly inhibits Gas6-induced AXL activation in 786-0-Luc RCC cells and inhibits downstream AKT phosphorylation. Tilvestamab can be used in cancer research, particularly in AXL overexpressing renal cell carcinomas.

For research use only. We do not sell to patients.

CAS No. : 2226775-26-2

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Based on 1 publication(s) in Google Scholar

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Description

Tilvestamab (BGB149) is a humanized anti-AXL antibody that blocks AXL-mediated cell signaling. Tilvestamab significantly inhibits Gas6-induced AXL activation in 786-0-Luc RCC cells and inhibits downstream AKT phosphorylation. Tilvestamab can be used in cancer research, particularly in AXL overexpressing renal cell carcinomas[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Humanized
IC50 & Target

Axl

 

In Vitro

Tilvestamab (250 μM; 1 h) inhibits AXL phosphorylation in 786-0 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tilvestamab Related Antibodies

Cell Viability Assay[1]

Cell Line: 786-0-Luc cells (Gas6- induced; Gas6 is a well characterized AXL ligand)
Concentration: 250 µM
Incubation Time: 1 h (pre-treat)
Result: Drastically inhibited Gas6- induced AXL phosphorylation and decreased the level of pAKT.
In Vivo

Tilvestamab (30 mg/kg; i.p.; twice a week) suppresses tumor growth by inhibiting AXL in orthotopic RCC model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c athymic nude mice (8-week-old; orthotopic RCC model)[1].
Dosage: 30 mg/kg
Administration: Intraperitoneal injection; twice a week
Result: Significantly inhibited RCC growth down to about 1/3 of the volume.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Tilvestamab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation

Purity: 98.08%

SDS (251 KB)

COA (231 KB) SDS-PAGE (93 KB) SEC-HPLC (107 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Tilvestamab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tilvestamab2226775-26-2BGB149BGB 149BGB-149TAM ReceptorTyro3AxlMerRCC786-0-Luc cellstumorcancerrenal cell carcinomaInhibitorinhibitorinhibit

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