GAS6 Protein, Human (630a.a, HEK293, His)

The GAS6 protein is a ligand for AXL, TYRO3 and MER receptors and affects a variety of cellular processes. GAS6/AXL signaling promotes endothelial cell survival, aids cytokine signaling in natural killer cell development, supports liver regeneration, affects gonadotropin-releasing hormone neuron survival and migration, modulates platelet activation, and regulates thrombotic responses. GAS6 Protein, Human (630a.a, HEK293, His) is the recombinant human-derived GAS6 protein, expressed by HEK293 , with C-His labeled tag. The total length of GAS6 Protein, Human (630a.a, HEK293, His) is 630 a.a., with molecular weight of 71-75 kDa.

GAS6, a ligand for tyrosine-protein kinase receptors AXL, TYRO3, and MER, is implicated in diverse cellular processes including cell growth, survival, adhesion, and migration. GAS6/AXL signaling contributes to endothelial cell survival under acidic conditions by preventing apoptosis, facilitates optimal cytokine signaling during human natural killer cell development, plays a role in hepatic regeneration, influences gonadotropin-releasing hormone neuron survival and migration, regulates platelet activation, and modulates thrombotic responses. Additionally, in microbial infections, GAS6 can act as a bridge between virus envelope phosphatidylserine and the TAM receptor tyrosine kinase Axl, facilitating viral entry through apoptotic mimicry. This unique function extends to its involvement in the entry processes of diverse viruses, including Dengue, Vaccinia, ebolavirus, and marburgvirus, highlighting the multifaceted roles of GAS6 in cellular and infectious contexts.

1. Immobilized Human GAS6, His Tag at 5 μg/mL (100 μl/well) on the plate. Dose response curve for Anti-GAS6 Antibody, hFc Tag with the EC₅₀ of ≤12.3 ng/mL determined by ELISA.
2. Immobilized Human GAS6, His Tag at 5 μg/mL (100 μl/well) on the plate. Dose response curve for Human Axl, hFc Tag with the EC₅₀ of <7.5 ng/mL determined by ELISA.

Human

HEK293

C-His

Q14393-2 (A49-A678)

2621  [NCBI]

71-75 kDa

Greater than 95% as determined by Tris-Bis PAGE.

Solution

Supplied as 0.22 μm filtered solution in 20 mM Tris, 500 mM NaCl (pH 8.5).

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.