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Results for "

IDE

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Fungal (1) IRE1 (1) MMP (1) Organoid (2) PKC (1) Small Interfering RNA (siRNA) (1) TGF-beta/Smad (1) Tyrosinase (1)
By Research Areas:	Cancer (3) Infection (1) Inflammation/Immunology (2) Metabolic Disease (7)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100533

IDE1 1 Publications Verification	Organoid	Inflammation/Immunology
IDE1 is an inducer of definitive endoderm 1.

HY-100534

IDE 2	Organoid TGF-beta/Smad	Others
IDE2 is a small molecule cell-permeable inducer of definitive endoderm formation in mouse and human embryonic stem cells (ESCs) by activating the TGF-βsignaling pathway .

HY-W157689

IDE-IN-2	Others	Infection Metabolic Disease Cancer
IDE-IN-3 (Compound 4) is an inhibitor for insulin-degrading enzyme. IDE-IN-3 is predicted to have CYP3A4, CYP2C19, hERG, NADP+, HIF1α and histidine kinase inhibitory activities, and has potential biological activity in anti-diabetic, anti-tumor, anti-bacterial aspects, according to the in silico prediction .

HY-101569

Darovasertib 3 Publications Verification LXS196; IDE196	PKC	Cancer
Darovasertib (LXS196) is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC₅₀ values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. Darovasertib has the potential for uveal melanoma research .

HY-110197

6bK TFA 1 Publications Verification	Others	Metabolic Disease
6bK TFA is a potent and selective insulin degrading enzyme (IDE) inhibitor with an IC₅₀ value of 50 nM. 6bK TFA increases circulating insulin in high-fat-fed mice. Acute administration of 6bK TFA enhances glucose tolerance to oral glucose, notably to a greater extent in high-fat-fed mice .

HY-117878

ML345	Others	Metabolic Disease
ML345 is a potent and selective insulin-degrading enzyme (IDE) small-molecule inhibitor, with an IC₅₀ value of 188 nM. ML345 can be for use as a pharmacophore for agent development in diabetes research .

HY-12655

IDE-IN-1	MMP	Metabolic Disease
IDE-IN-1 (compound 6bK) is an insulin-degrading enzyme (IDE) inhibitor with IC₅₀ value of 50 nM. IDE-IN-1 can be used to study type 2 diabetes .

HY-RS06526

IDE Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IDE Human Pre-designed siRNA Set A contains three designed siRNAs for IDE gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IDE Human Pre-designed siRNA Set A IDE Human Pre-designed siRNA Set A

HY-143401

Hit 1	Others	Metabolic Disease
Hit 1 is an activator of ansulin degrading enzyme (IDE), with an EC₅₀ of 5.5 μM. Hit 1 can decrease glucose-stimulating insulin secretion .

HY-114611

BDM44768	IRE1	Metabolic Disease
BDM44768 is an inhibitior of *IDE*. BDM44768 exacerbates ER stress-induced IRE1 activation and promotes lipid accumulation in hepatocytes. BDM44768 potentiates activation of the IRE1 pathway in the liver and exacerbates liver lipid accumulation in an acute mice model of ER stress .

HY-N7135

Tropolone	Tyrosinase Fungal	Metabolic Disease Inflammation/Immunology Cancer
Tropolone is a seven-membered non-benzenoid aromatic compound, which is the precursor of many Azulene derivatives. Tropolone is a potent mushroom tyrosinase inhibitor with an IC₅₀ value of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU ²⁺ Reversa. Tropolone exhibits broad anti-viral and anti-fungal activity and is synergistic upon co-treatment with nucleos(t)ide analog drugs. Tropolone is a promising candidate for research in osteosarcoma .

Tropolone	Olax imbricata Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Olacaceae Source classification Other Diseases Plants Disease Research Fields	Tyrosinase Fungal
Tropolone is a seven-membered non-benzenoid aromatic compound, which is the precursor of many Azulene derivatives. Tropolone is a potent mushroom tyrosinase inhibitor with an IC₅₀ value of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU ²⁺ Reversa. Tropolone exhibits broad anti-viral and anti-fungal activity and is synergistic upon co-treatment with nucleos(t)ide analog drugs. Tropolone is a promising candidate for research in osteosarcoma .

Cat. No.	Compare	Product Name	Species	Source

HY-P70291

	*Insulysin/IDE* Protein, Human (HEK293, His)** rHuInsulin-degrading enzyme/IDE, His ; Insulin-Degrading Enzyme; Abeta-Degrading Protease; Insulin Protease; Insulinase; Insulysin; IDE	Human	HEK293
	Insulin/IDE protein is the key to the decomposition of cellular peptides. It participates in the degradation of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kinins and other peptides, and affects intercellular peptide signaling. Substrate binding induces conformational changes that promote degradation of larger substrates such as insulin. Insulysin/IDE Protein, Human (HEK293, His) is the recombinant human-derived Insulysin/IDE protein, expressed by HEK293 , with C-6*His labeled tag.

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IDE Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
IDE Human Pre-designed siRNA Set A contains three designed siRNAs for IDE gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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