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Results for "

LTA4 hydrolase

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

2

Natural
Products

3

Recombinant Proteins

1

Antibodies

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-103226
    SC-57461A
    1 Publications Verification

    		 Aminopeptidase Inflammation/Immunology
    SC-57461A is a potent, orally active, nonpeptide, and selective inhibitor of Leukotriene A4 (LTA4) hydrolase with IC50s of 2.5 nM, 3 nM, and 23 nM for recombinant human, mouse, and rat LTA4 hydrolase, respectively .
    SC-57461A
  • HY-137298
    LYS006

    LTA4H-IN-1

    		 Aminopeptidase Inflammation/Immunology
    LTA4H-IN-1 is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) extracted from patent WO2015092740A1, example 29, has an IC50 of 2 nM. LTA4H-IN-1 can be used for the research of inflammatory and autoimmune disorders .
    LYS006
  • HY-W004291
    Methyl arachidate

    Methyl icosanoate

    		 Aminopeptidase Inflammation/Immunology
    Methyl arachidate (Methyl eicosanoate), a natural compound, is a leukotriene A4 hydrolase (LTA4H) inhibitor .
    Methyl arachidate
  • HY-118795
    SC-22716

    		Aminopeptidase Inflammation/Immunology
    SC-22716 is a potent, competitive, reversible inhibitor of human LTA4 hydrolase, with an IC50 of 0.20 µM. SC-22716 has potential for the research of inflammatory bowel disease (IBD) and psoriasis .
    SC-22716
  • HY-112621
    Leukotriene A4 methyl ester

    LTA4 methyl ester

    		 Others Inflammation/Immunology
    Leukotriene A4 (LTA4) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities. LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively.2 LTA4, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells.3 Further metabolism of LTA4 by 15-LO leads to lipoxin biosynthesis.2 LTA4 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.
    Leukotriene A4 methyl ester
  • HY-162710
    LTA4H-IN-5

    		Aminopeptidase Inflammation/Immunology
    LTA4H-IN-5 (Compound H122) is an orally active inhibitor for leukotriene A4 hydrolase (LTA4H), that inhibits the LTA4H aminopeptidase and LTA4H hydrolase with IC50 of 0.38 nM and 16.93 nM. LTA4H-IN-5 exhibits good pharmacokinetic characteristics in C57 mice and ameliorates the DNBS-induced ulcerative enteritis in rat models .
    LTA4H-IN-5
  • HY-162015
    LTA4H-IN-2

    		Aminopeptidase Inflammation/Immunology
    LTA4H-IN-2 (compound (S)-2 ) is an orally active inhibitor of Leukotriene A4 Hydrolase, with an IC50 of <3 nM .
    LTA4H-IN-2
  • HY-W004291R
    Methyl arachidate (Standard)

    Methyl icosanoate (Standard)

    		 Aminopeptidase Inflammation/Immunology
    Methyl arachidate (Standard) is the analytical standard of Methyl arachidate. This product is intended for research and analytical applications. Methyl arachidate (Methyl eicosanoate), a natural compound, is a leukotriene A4 hydrolase (LTA4H) inhibitor .
    Methyl arachidate (Standard)
  • HY-156960
    JNJ-40929837

    		Aminopeptidase Leukotriene Receptor Inflammation/Immunology
    JNJ-40929837 is a selective and orally active LTA4H (leukotriene A4 hydrolase) inhibitor. JNJ-40929837 effectively inhibits aminopeptidase activity and causes serum accumulation of Pro-Gly-Pro. JNJ-40929837 can be used in asthma research .
    JNJ-40929837
  • HY-156960A
    JNJ-40929837 succinate

    		Aminopeptidase Leukotriene Receptor Inflammation/Immunology
    JNJ-40929837 succinate is a selective and orally active LTA4H (leukotriene A4 hydrolase) inhibitor. JNJ-40929837 succinate effectively inhibits aminopeptidase activity and causes serum accumulation of Pro-Gly-Pro. JNJ-40929837 succinate can be used in asthma research .
    JNJ-40929837 succinate
  • HY-10826
    DG051 free acid

    		Aminopeptidase Cardiovascular Disease Neurological Disease
    DG051 (free acid) is an effective inhibitor of leukotriene A4 hydrolase (LTA4H), with a Kd of 26 nM. It has high water solubility (greater than 30 mg/mL) and high oral bioavailability (over 80% across different species). DG051 (free acid) can be used in research related to myocardial infarction and stroke .
    DG051 free acid

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