2. Metabolic Enzyme/Protease
  3. Aminopeptidase
  4. LTA4H-IN-5

LTA4H-IN-5 (Compound H122) is an orally active inhibitor for leukotriene A4 hydrolase (LTA4H), that inhibits the LTA4H aminopeptidase and LTA4H hydrolase with IC50 of 0.38 nM and 16.93 nM. LTA4H-IN-5 exhibits good pharmacokinetic characteristics in C57 mice and ameliorates the DNBS-induced ulcerative enteritis in rat models.

For research use only. We do not sell to patients.

LTA4H-IN-5 Chemical Structure

LTA4H-IN-5 Chemical Structure

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LTA4H-IN-5 Related Antibodies

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Description

LTA4H-IN-5 (Compound H122) is an orally active inhibitor for leukotriene A4 hydrolase (LTA4H), that inhibits the LTA4H aminopeptidase and LTA4H hydrolase with IC50 of 0.38 nM and 16.93 nM. LTA4H-IN-5 exhibits good pharmacokinetic characteristics in C57 mice and ameliorates the DNBS-induced ulcerative enteritis in rat models[1].

IC50 & Target[1]

LTA4H aminopeptidase

0.38 nM (IC50)

LTA4H aminopeptidase

16.93 nM (IC50)

Molecular Weight

443.26

Formula

C18H17Cl2FN4O4
SMILES

ClC1=CN=C(OC2=CC(C)=C(C3=NOC(C[C@H](CC(O)=O)N)=N3)C=C2)C(F)=C1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LTA4H-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LTA4H-IN-5AminopeptidaseC57 mouseWistar ratorally activeulcerative enteritisInhibitorinhibitorinhibit

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