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Isoforms Recommended:	LTC₄/CysLT₂

Results for "

LTC4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Calcium Channel (2) Cytochrome P450 (1) Drug Metabolite (1) Endogenous Metabolite (7) Glutathione S-transferase (2) Histamine Receptor (6) Isotope-Labeled Compounds (3) Leukotriene Receptor (21) Lipoxygenase (1) PPAR (1) Prostaglandin Receptor (5) Small Interfering RNA (siRNA) (1) Syk (1) TNF Receptor (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (2) Endocrinology (5) Inflammation/Immunology (27) Metabolic Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-118958

Ablukast Ro 23-3544	Leukotriene Receptor	Inflammation/Immunology
Ablukast (Ro 23-3544) is a specific and active leukotriene receptor antagonist. Ablukast effectively reduces LTC4- and antigen-induced bronchoconstriction . Ablukast is LTD4 receptor antagonist .

HY-U00027

Quinotolast sodium FR71021	Histamine Receptor Leukotriene Receptor Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Quinotolast sodium in the concentration range of 1-100 μg/mL inhibits histamine, *LTC₄* and PGD₂ release in a concentration-dependent manner.

HY-13448

Nedocromil FPL 59002	Histamine Receptor Leukotriene Receptor Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Nedocromil suppresses the action or formation of multiple mediators, including histamine, leukotriene C₄ (LTC₄), and prostaglandin D₂ (PGD₂).

HY-RS07882

LTC4S Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LTC4S Human Pre-designed siRNA Set A contains three designed siRNAs for LTC4S gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LTC4S Human Pre-designed siRNA Set A LTC4S Human Pre-designed siRNA Set A

HY-113460

11-trans-Leukotriene C4	Endogenous Metabolite	Inflammation/Immunology
11-trans-Leukotriene C4 is trans-Leukotriene C4 (LTC4). LTC4 is an important inflammatory mediator and regulator of allergic responses .

HY-120755

LY290324	Leukotriene Receptor	Inflammation/Immunology
LY290324 is a potent and orally active leukotriene D4 (LTD4) antagonist. LY290324 reduces LTC4, LTD4 and LTE4 (HY-113465)-induced bronchospasm. LY290324 has the potential for the research of antigen-induced bronchospasm .

HY-116560

ONO-8809	Others	Inflammation/Immunology
ONO-8809 is a Thromboxane A2 receptor antagonist. ONO-8809 inhibits the LTC4-induced airway hyperresponsiveness to histamine in a dose-dependent manner .

HY-101686

LM-1484	Leukotriene Receptor	Inflammation/Immunology
LM-1484 is an antagonist of CysLT1 receptor and displays a higher affinity for ³H-LTC4 sites.

HY-124252

5,8,11-Eicosatriynoic acid ETI	Lipoxygenase	Cancer
5,8,11-Eicosatriynoic acid (ETI) is a lipoxygenase inhibitor that blocks LTC4 biosynthesis in mast cell tumor cells .

HY-16344

Nedocromil sodium FPL 59002KP; Nedocromil disodium salt	Histamine Receptor Leukotriene Receptor Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Nedocromil sodium suppresses the action or formation of multiple mediators, including histamine, leukotriene C₄ (LTC₄), and prostaglandin D₂ (PGD₂).

HY-113456S

Leukotriene D4-d5	Drug Metabolite Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Leukotriene D4-d₅ is the deuterium labeled Leukotriene D4. Leukotriene D4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. Leukotriene D4 is the first cysteinyl-leukotriene metabolite of LTC4. Leukotriene D4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.

HY-101676

RG-12525 NID 525	Leukotriene Receptor PPAR Cytochrome P450	Metabolic Disease
RG-12525 is a a specific, competitive and orally effective antagonist of the peptidoleukotrienes, *LTC4, LTD4* and *LTE4, inhibiting LTC4-, LTD4- and LTE4-inducd guinea pig parenchymal strips contractions, with IC₅₀s of 2.6 nM, 2.5 nM and 7 nM, respectively; RG-12525 is also a peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist with IC₅₀* of appr 60 nM and a potent inhibitor of *CYP3A4*, with a K_i value of 0.5 µM.

HY-135336A

(S)-Verapamil hydrochloride (S)-(-)-Verapamil hydrochloride	Leukotriene Receptor Calcium Channel Apoptosis	Cancer
(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells .

HY-120931

LY329146	Leukotriene Receptor	Cancer
LY329146, a Raloxifene (HY-13738) analog, is multidrug resistance protein (MRP1) inhibitor. LY329146 inhibits leucotriene C4 ( LTC4) transport with an IC₅₀ of 0.8 μM .

HY-13448R

Nedocromil (Standard)	Histamine Receptor Leukotriene Receptor Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Nedocromil (Standard) is the analytical standard of Nedocromil. This product is intended for research and analytical applications. Nedocromil suppresses the action or formation of multiple mediators, including histamine, leukotriene C₄ (LTC₄), and prostaglandin D₂ (PGD₂).

HY-113446S

Leukotriene C4-d5	Endogenous Metabolite Isotope-Labeled Compounds	Cardiovascular Disease Inflammation/Immunology
Leukotriene C4-d₅ is the deuterium labeled Leukotriene C4. Leukotriene C4 is the parent cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4.

HY-101946

AS-35	Leukotriene Receptor	Inflammation/Immunology
AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum with IC₅₀ values of 8 nM, 4 nM and 3 nM, respectively, and has antiallergic activities.

HY-U00364

CI-949	Histamine Receptor Prostaglandin Receptor Leukotriene Receptor	Inflammation/Immunology Endocrinology
CI-949 is an allergic mediator release inhibitor, which inhibits histamine, leukotriene C₄/D₄ (LTC₄/LTD₄), and thromboxane B₂ (TXB₂) release with IC₅₀s of 11.4 μM, 0.5 μM and 0.1 μM, respectively.

HY-112621

Leukotriene A4 methyl ester LTA4 methyl ester	Others	Inflammation/Immunology
Leukotriene A4 (LTA4) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities. LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively.2 LTA4, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells.3 Further metabolism of LTA4 by 15-LO leads to lipoxin biosynthesis.2 LTA4 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.

HY-135336AS

(S)-Verapamil-d7 hydrochloride (S)-(-)-Verapamil-d₇ hydrochloride	Isotope-Labeled Compounds Leukotriene Receptor Calcium Channel Apoptosis	Cancer
(S)-Verapamil-d₇ (hydrochloride) is a deuterium labeled (S)-Verapamil hydrochloride. (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells[1][2].

HY-113628

ABT-080 VML-530	Leukotriene Receptor	Inflammation/Immunology
ABT-080 is an orally active inhibitor of leukotriene biosynthesis. ABT-080 simultaneously blocks the leukotriene pathways leading to the synthesis of *LTB₄* and *LTC₄*, but does not inhibit PGH2 biosynthesis. ABT-080 can block bronchoconstriction and be used in the research of asthma and related inflammations

HY-B0290

Pranlukast 1 Publications Verification ONO-1078	Leukotriene Receptor Endogenous Metabolite	Inflammation/Immunology
Pranlukast is a highly potent, selective and competitive antagonist of peptide leukotrienes. Pranlukast inhibits [ ³H]LTE₄, [ ³H]LTD₄, and [ ³H]LTC₄ bindings to lung membranes with K_is of 0.63±0.11, 0.99±0.19, and 5640±680 nM, respectively.

HY-B0290A

Pranlukast hemihydrate 1 Publications Verification ONO-1078 hemihydrate	Leukotriene Receptor Endogenous Metabolite	Inflammation/Immunology
Pranlukast hemihydrate is a highly potent, selective and competitive antagonist of peptide leukotrienes. Pranlukast inhibits [ ³H]LTE₄, [ ³H]LTD₄, and [ ³H]LTC₄ bindings to lung membranes with K_is of 0.63±0.11, 0.99±0.19, and 5640±680 nM, respectively.

HY-B0290S1

Pranlukast-d4 ONO-1078-d₄	Isotope-Labeled Compounds Leukotriene Receptor Endogenous Metabolite	Inflammation/Immunology
Pranlukast-d₄ is deuterium labeled Pranlukast. Pranlukast is a highly potent, selective and competitive antagonist of peptide leukotrienes. Pranlukast inhibits [3H]LTE4, [3H]LTD4, and [3H]LTC4 bindings to lung membranes with Kis of 0.63±0.11, 0.99±0.19, and 5640±680 nM, respectively.

HY-B0290R

Pranlukast (Standard)	Leukotriene Receptor Endogenous Metabolite	Inflammation/Immunology
Pranlukast (Standard) is the analytical standard of Pranlukast. This product is intended for research and analytical applications. Pranlukast is a highly potent, selective and competitive antagonist of peptide leukotrienes. Pranlukast inhibits [ ³H]LTE₄, [ ³H]LTD₄, and [ ³H]LTC₄ bindings to lung membranes with K_is of 0.63±0.11, 0.99±0.19, and 5640±680 nM, respectively.

HY-19042

YM-16638 YM 638	Leukotriene Receptor	Inflammation/Immunology
YM-16638 is an orally active leukotriene (LT) antagonist. YM-16638 can inhibit the production of LTC₄, LTD₄, and LTE₄ in guinea pig trachea, with IC₅₀ values of 0.05 μM, 0.16 μM, and 0.096 μM, respectively. YM-16638 has a dose-dependent inhibitory effect on antigen-induced early and late respiratory responses in allergic sheep .

HY-B0539

Desloratadine Maximum Cited Publications 9 Publications Verification Sch34117	Histamine Receptor TNF Receptor Leukotriene Receptor	Inflammation/Immunology
Desloratadine (Sch34117) is an orally active and selective H1 receptor antagonist (K_i=0.9 nM) with anti-inflammatory and anti-allergic activities. Desloratadine inhibits the release of histamine and LTC4 from human basophils and targets the regulatory signals of *IL-4* and IL-13 production in basophils. Desloratadine significantly alleviates SAR symptoms in patients with concurrent asthma and can be used in the study of seasonal allergic rhinitis and chronic idiopathic urticaria ^[4] .

HY-114796

tHGA	Others	Inflammation/Immunology
tHGA is a compound with anti-inflammatory activity and has the activity to inhibit soybean 15-LOX. tHGA showed significant inhibitory effects in experiments on human leukocytes, with an IC₅₀ value of 0.42 μM, which is close to the effect of commonly used standard NDGA. tHGA concentration-dependently inhibits the synthesis of 5-LOX products, especially the cysteine leukotriene LTC(4), with an IC₅₀ value of 1.80 μM. and showed no cytotoxicity. The anti-inflammatory effects of tHGA do not appear to be through redox or metal chelation mechanisms, as the compound was negative in these bioactivity tests. tHGA works through a dual LOX/COX inhibition mechanism and has higher selectivity for 5-LOX and COX-2, with an IC₅₀ value of 0.40 μM .

HY-117854

SB 201146	Leukotriene Receptor	Inflammation/Immunology
SB 201146 is an *LTB4* receptor antagonist with a potency range of 10 pM to 1 μM that plays a critical role in asthma-associated airway inflammation. Studies have focused on its effects on eosinophil survival, a hallmark of asthma pathology. Studies have shown that eosinophil-derived cysteinyl leukotrienes, including LTC4 and LTD4, as well as factors such as GM-CSF and fibronectin promote eosinophil survival. SB 201146 effectively reversed mast cell- and lymphocyte-induced eosinophil survival, highlighting its potential therapeutic role in disrupting the autocrine cysteinyl leukotriene pathway that maintains eosinophil viability. This antagonist also highlights the importance of LTB4 as a paracrine mediator that influences eosinophil survival in inflammatory settings such as asthma .

HY-117811

(R,R)-MK 287 L-680574	Others	Others
(R,R)-MK 287 is a tetrahydrofuran derivative that effectively inhibits the binding of [3H]C18-PAF to human platelets, polymorphonuclear leukocytes (PMNs), and lung membranes with K1 values of 6.1 ± 1.5, 3.2 ± 0.7, and 5.49 ± 2.3 nM, respectively. The inhibition is stereospecific and competitive. Its racemate, L-668,750, is less potent, and its enantiomer, L-680574, is only 1/20 as potent as MK 287. MK 287 inhibits the binding of [3H]C18-PAF to human PMN membranes, reducing the affinity of the radioligand without changing the number of receptor sites. The binding of other radioligands (e.g., LTB4, LTC4, C5a, FMLP) to their specific receptors is unchanged at 1-10 microM MK 287. [3H]MK 287 binds to human platelet and PMN membranes with KD values of 2.1 ± 0.6 and 2.9 ± 1.2 nM. When tested on isolated human cells, MK 287 potently and selectively inhibits PAF-induced platelet aggregation (ED50 = 56 ± 38 nM or ED50 = 1.5 ± 0.5 nM for gel-filtered platelets) and elastase release from PMNs (ED50 = 4.4 ± 2.6 nM). In vivo studies, MK 287 inhibited PAF-induced lethality in mice (ED50 = 0.8 mg/kg oral) and PAF-induced bronchospasm in guinea pigs (ED50 = 0.18 mg/kg intraduodenally and 0.19 mg/kg intravenously). The inhibition of PAF-induced bronchospasm was accompanied by a rightward shift in the concentration-response curve for PAF-induced platelet aggregation measured in vitro.

HY-134092

N-Methyl Leukotriene C4 N-Methyl-LTC4	Others	Inflammation/Immunology
N-Methyl Leukotriene C4 stimulates contraction of airway smooth muscle in animals, with efficacy varying by tissue and species. For example, it can stimulate the lungs of bullfrogs to contract .

HY-117143

TK05	Glutathione S-transferase	Inflammation/Immunology
TK05 is a potent and selective inhibitor of leukotriene C₄ synthase (LTC4S) with an IC₅₀ of 95 nM .

HY-126329

AZD9898	Glutathione S-transferase	Inflammation/Immunology
AZD9898 is an orally active leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC₅₀ of 0.28 nM. AZD9898 mitigates the GABA binding and hepatic toxicity signal. AZD9898 has the potential to treat asthma .

HY-16420

R112	Syk	Inflammation/Immunology
R112 is a fast and reversible inhibitor of spleen tyrosine kinase (Syk) kinase. R112 inhibits Syk kinase activity with an IC₅₀ value of 226 nM and a Ki value of 96 nM. R112 inhibits IgE-FcεRI signaling pathway. R112 can be used for the research of allergic rhinitis .

Pranlukast 1 Publications Verification ONO-1078	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Leukotriene Receptor Endogenous Metabolite
Pranlukast is a highly potent, selective and competitive antagonist of peptide leukotrienes. Pranlukast inhibits [ ³H]LTE₄, [ ³H]LTD₄, and [ ³H]LTC₄ bindings to lung membranes with K_is of 0.63±0.11, 0.99±0.19, and 5640±680 nM, respectively.

Pranlukast hemihydrate 1 Publications Verification ONO-1078 hemihydrate	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Leukotriene Receptor Endogenous Metabolite
Pranlukast hemihydrate is a highly potent, selective and competitive antagonist of peptide leukotrienes. Pranlukast inhibits [ ³H]LTE₄, [ ³H]LTD₄, and [ ³H]LTC₄ bindings to lung membranes with K_is of 0.63±0.11, 0.99±0.19, and 5640±680 nM, respectively.

Desloratadine Maximum Cited Publications 9 Publications Verification Sch34117	Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology	Histamine Receptor TNF Receptor Leukotriene Receptor
Desloratadine (Sch34117) is an orally active and selective H1 receptor antagonist (K_i=0.9 nM) with anti-inflammatory and anti-allergic activities. Desloratadine inhibits the release of histamine and LTC4 from human basophils and targets the regulatory signals of *IL-4* and IL-13 production in basophils. Desloratadine significantly alleviates SAR symptoms in patients with concurrent asthma and can be used in the study of seasonal allergic rhinitis and chronic idiopathic urticaria ^[4] .

11-trans-Leukotriene C4	Structural Classification Natural Products Animals Source classification	Endogenous Metabolite
11-trans-Leukotriene C4 is trans-Leukotriene C4 (LTC4). LTC4 is an important inflammatory mediator and regulator of allergic responses .

Pranlukast (Standard)	Structural Classification Alkaloids Other Alkaloids Source classification Endogenous metabolite	Leukotriene Receptor Endogenous Metabolite
Pranlukast (Standard) is the analytical standard of Pranlukast. This product is intended for research and analytical applications. Pranlukast is a highly potent, selective and competitive antagonist of peptide leukotrienes. Pranlukast inhibits [ ³H]LTE₄, [ ³H]LTD₄, and [ ³H]LTC₄ bindings to lung membranes with K_is of 0.63±0.11, 0.99±0.19, and 5640±680 nM, respectively.

Species:	Human (4)
Tag:	GFP (2) His (4) Strep (2)
Source:	HEK293 (2) Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P75919

	LTC4S Protein, Human (sf9, His) Leukotriene C4 synthase; LTC4 synthase; LTC4S	Human	Sf9 insect cells
	LTC4S protein catalyzes the specific binding of leukotriene A4 and reduced glutathione (GSH) to generate leukotriene C4. LTC4S Protein, Human (sf9, His) is the recombinant human-derived LTC4S protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of LTC4S Protein, Human (sf9, His) is 150 a.a., with molecular weight of ~17 kDa.

HY-P701355

	bABCC1 Protein, Human (HEK293, GFP, Strep, His) ABCC1; Multidrug resistance-associated protein 1; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; Leukotriene C(4) transporter; LTC4 transporter	Human	HEK293
	The bABCC1 protein plays a key role in cellular physiology, mediating the ATP-dependent export of a variety of substrates, including drugs and organic anions. Notably, it confers resistance to anticancer drugs, actively reducing their intracellular accumulation. bABCC1 Protein, Human (HEK293, GFP, Strep, His) is the recombinant human-derived bABCC1 protein, expressed by HEK293 , with C-10*His, C-GFP, C-Strep labeled tag. The total length of bABCC1 Protein, Human (HEK293, GFP, Strep, His) is 1530 a.a., .

HY-P701356

	bABCC1 Protein, Human (HEK293, E1454Q, GFP, Strep, His) ABCC1; Multidrug resistance-associated protein 1; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; Leukotriene C(4) transporter; LTC4 transporter	Human	HEK293
	The bABCC1 protein plays a key role in cellular physiology, mediating the ATP-dependent export of a variety of substrates, including drugs and organic anions. Notably, it confers resistance to anticancer drugs, actively reducing their intracellular accumulation. bABCC1 Protein, Human (HEK293, E1454Q, GFP, Strep, His) is the recombinant human-derived bABCC1 protein, expressed by HEK293 , with C-10*His, C-GFP, C-Strep labeled tag and E1454Q, , , , mutation. The total length of bABCC1 Protein, Human (HEK293, E1454Q, GFP, Strep, His) is 1530 a.a., .

HY-P72069

	ABCC1 Protein, Human (His) ABC 29; ABC29; ABCC 1; ABCC; Abcc1; ATP binding cassette sub family C CFTR/MRP; member 1; ATP binding cassette sub-family C member 1; ATP binding cassette subfamily C member 1; ATP binding cassette transporter variant ABCC1delta ex13; ATP binding cassette transporter variant ABCC1delta ex13&14; ATP binding cassette transporter variant ABCC1delta ex25; ATP binding cassette transporter variant ABCC1delta ex25&26; ATP binding cassette, sub-family C CFTR/MRP; , member 1; ATP-binding cassette sub-family C member 1; DKFZp686N04233; DKFZp781G125; GS X; GSX; Leukotriene C4; transporter; LTC4 transporter; MRP 1; MRP; MRP1; MRP1_HUMAN; Multidrug resistance associated protein 1; Multidrug resistance protein; Multidrug resistance-associated protein 1; Multiple drug resistance associated protein; Multiple drug resistance protein 1	Human	E. coli
	ABCC1, Human (His) is a multitasking ATP-binding cassette (ABC) transporter. ABCC1, Human plays a part in inflammatory and other immunological diseases, age-related macular degeneration, cardiovascular disease, and certain neurological disorders as well as tumor progression.

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Cat. No.	Product Name	Chemical Structure

HY-113456S

Leukotriene D4-d5

Leukotriene D4-d₅ is the deuterium labeled Leukotriene D4. Leukotriene D4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. Leukotriene D4 is the first cysteinyl-leukotriene metabolite of LTC4. Leukotriene D4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.