2. Metabolic Enzyme/Protease
  3. Glutathione S-transferase
  4. TK05

TK05 is a potent and selective inhibitor of leukotriene C4 synthase (LTC4S) with an IC50 of 95 nM.

For research use only. We do not sell to patients.

TK05 Chemical Structure

TK05 Chemical Structure

CAS No. : 1245734-61-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 594 In-stock
Solution
10 mM * 1 mL in DMSO USD 594 In-stock
Solid
5 mg USD 540 In-stock
10 mg USD 880 In-stock
25 mg USD 1750 In-stock
50 mg USD 2800 In-stock
100 mg USD 4500 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

TK05 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

TK05 is a potent and selective inhibitor of leukotriene C4 synthase (LTC4S) with an IC50 of 95 nM[1].

IC50 & Target

IC50: 95 nM (Leukotriene C4 synthase)[1]
In Vitro

TK05 reduces LTC4 production in a dose-dependent manner with an IC50 value of 318 ± 60 nM in MM6 Cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TK05 Related Antibodies
In Vivo

TK05 (0.12-6 mg/kg; given i.p.; only once) significantly reduces LTE4 levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Zymosan A induced peritonitis mouse model[1]
Dosage: 0.12 mg/kg; 6 mg/kg
Administration: Given i.p.; only once
Result: 0.12 mg/kg of TK05 significantly reduced LTE4 levels, whereas 6 mg/kg body weight of the compound resulted in almost complete inhibition compared with mice treated with only Zymosan A.
Molecular Weight

540.99

Formula

C31H25ClN2O5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

ClC1=CC=C(N(CC2CC2)C3=CC=C(C(C4=CC(C(O)=O)=C(C(C5=CC=C(OC)C=C5)=O)C=C4)=O)N=C3)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (184.85 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8485 mL 9.2423 mL 18.4846 mL
5 mM 0.3697 mL 1.8485 mL 3.6969 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8485 mL 9.2423 mL 18.4846 mL 46.2116 mL
5 mM 0.3697 mL 1.8485 mL 3.6969 mL 9.2423 mL
10 mM 0.1848 mL 0.9242 mL 1.8485 mL 4.6212 mL
15 mM 0.1232 mL 0.6162 mL 1.2323 mL 3.0808 mL
20 mM 0.0924 mL 0.4621 mL 0.9242 mL 2.3106 mL
25 mM 0.0739 mL 0.3697 mL 0.7394 mL 1.8485 mL
30 mM 0.0616 mL 0.3081 mL 0.6162 mL 1.5404 mL
40 mM 0.0462 mL 0.2311 mL 0.4621 mL 1.1553 mL
50 mM 0.0370 mL 0.1848 mL 0.3697 mL 0.9242 mL
60 mM 0.0308 mL 0.1540 mL 0.3081 mL 0.7702 mL
80 mM 0.0231 mL 0.1155 mL 0.2311 mL 0.5776 mL
100 mM 0.0185 mL 0.0924 mL 0.1848 mL 0.4621 mL
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TK05 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TK051245734-61-5TK 05TK-05Glutathione S-transferaseGlutathione transferasesGSTsInhibitorinhibitorinhibit

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