2. Metabolic Enzyme/Protease
  3. Glutathione S-transferase
  4. AZD9898

AZD9898 is an orally active leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC50 of 0.28 nM. AZD9898 mitigates the GABA binding and hepatic toxicity signal. AZD9898 has the potential to treat asthma.

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AZD9898 Chemical Structure

AZD9898 Chemical Structure

CAS No. : 2042347-69-1

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1 mg USD 260 In-stock
5 mg USD 650 In-stock
10 mg USD 975 In-stock
25 mg USD 1540 In-stock
50 mg USD 2070 In-stock
100 mg USD 2795 In-stock
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Based on 1 publication(s) in Google Scholar

AZD9898 Related Antibodies

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Description

AZD9898 is an orally active leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC50 of 0.28 nM. AZD9898 mitigates the GABA binding and hepatic toxicity signal. AZD9898 has the potential to treat asthma[1].

IC50 & Target

IC50: 0.28 nM (LTC4S)[1].
In Vivo

AZD9898 with the single dose of 100 mg/kg is well tolerated and no safety concerns are raised[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat 6M/group[1].
Dosage: 10 and 100 mg/kg (for Toxicology Study).
Administration: Sing oral dose.
Result: Showed no signs of testicular toxicity, and only adaptive changes in the liver due to cytochrome P450 induction which were not judged adverse, providing a 200 fold margin between the no adverse effect level and the predicted human exposure at the predicted therapeutic dose.
Clinical Trial
Molecular Weight

457.83

Formula

C20H19ClF3N3O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C([C@@H]1[C@@H](C(C2=NC=C(N(C3=CC(Cl)=C(F)C=C3F)CC(C)(F)C)N=C2OC)=O)C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (546.05 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1842 mL 10.9211 mL 21.8422 mL
5 mM 0.4368 mL 2.1842 mL 4.3684 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1842 mL 10.9211 mL 21.8422 mL 54.6054 mL
5 mM 0.4368 mL 2.1842 mL 4.3684 mL 10.9211 mL
10 mM 0.2184 mL 1.0921 mL 2.1842 mL 5.4605 mL
15 mM 0.1456 mL 0.7281 mL 1.4561 mL 3.6404 mL
20 mM 0.1092 mL 0.5461 mL 1.0921 mL 2.7303 mL
25 mM 0.0874 mL 0.4368 mL 0.8737 mL 2.1842 mL
30 mM 0.0728 mL 0.3640 mL 0.7281 mL 1.8202 mL
40 mM 0.0546 mL 0.2730 mL 0.5461 mL 1.3651 mL
50 mM 0.0437 mL 0.2184 mL 0.4368 mL 1.0921 mL
60 mM 0.0364 mL 0.1820 mL 0.3640 mL 0.9101 mL
80 mM 0.0273 mL 0.1365 mL 0.2730 mL 0.6826 mL
100 mM 0.0218 mL 0.1092 mL 0.2184 mL 0.5461 mL
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AZD9898 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZD98982042347-69-1AZD 9898AZD-9898Glutathione S-transferaseGlutathione transferasesGSTsInhibitorinhibitorinhibit

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