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Results for "

Mac1

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

3

Peptides

1

Inhibitory Antibodies

1

Recombinant Proteins

2

Antibodies

1

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-150062
    SARS-CoV-2 nsp3-IN-1

    		SARS-CoV Infection
    SARS-CoV-2 nsp3-IN-1 (Compound 15c) is a Mac1 (SARS-CoV-2 nsp3 macrodomain) inhibitor with the IC50 value of 6.1 μM. SARS-CoV-2 nsp3-IN-1 can inhibit Mac1 ADP-ribosylhydrolase activity. SARS-CoV-2 nsp3-IN-1 demonstrates notable selectivity for coronavirus macrodomains, especially towards SARS-CoV-2 Mac1 [1].
    SARS-CoV-2 nsp3-IN-1
  • HY-18315
    Bayer-18

    		JAK Apoptosis Cancer
    Bayer-18 is an inhibitor for TYK2. Bayer-18 inhibits the viability of ALCL cell K299, SR786, Mac1 and Mac2a with IC50 of 2-3 µM, and induces apoptosis in K299 and SR786 [1].
    Bayer-18
  • HY-P9934
    Abciximab

    C7E3

    		 Integrin Cardiovascular Disease
    Abciximab (C7E3), a chimeric mouse/human monoclonal antibody fragment, is a glycoprotein (GP) IIb/IIIa inhibitor. Abciximab inhibits platelet aggregation and leucocyte adhesion by binding to the glycoprotein IIb/IIIa, vitronectin and Mac-1 receptors [1].
    Abciximab
  • HY-P10547
    Macropin

    Mac-1 peptide

    		 Bacterial Infection
    Macropin (MAC-1 peptide) is an antimicrobial peptide found in the venom of the solitary bee Macropis fulvipes. Macropin has antibacterial activity against both Gram-positive and Gram-negative bacteria, and also exhibits inhibitory activity against fungi and moderate hemolytic activity against human erythrocytes. Macropin can be used in research on anti-infective therapy [1].
    Macropin
  • HY-161114
    MDOLL-0229

    		SARS-CoV Infection
    MDOLL-0229 (compound 27) is an antiviral agent that targets SARS-CoV-2 Mac1 and repress coronavirus replication. MDOLL-0229 inhibits SARS-CoV-2 Mac1 with an IC50 of 2.1 µM [1].
    MDOLL-0229
  • HY-160943A
    F594-1001 hydrochloride

    		SARS-CoV Infection
    F594-1001 (compound 6) hydrochloride is a potent and highly selective SARS-CoV-2 Mac1-ADP-ribose inhibitor with IC50s of 8.5 μM, 68 μM and 45 μM for SARS-CoV-2 in AS, FP, and FRET assays, respectively. F594-1001 hydrochloride directly binds to SARS-CoV-2 Mac1 and exhibits a dose-dependent inhibition of Mac1 ADP-ribosylhydrolase activity [1].
    F594-1001 hydrochloride
  • HY-160943
    F594-1001

    		SARS-CoV Infection
    F594-1001 (compound 6) is a potent and highly selective SARS-CoV-2 Mac1-ADP-ribose inhibitor with IC50s of 8.5 μM, 68 μM and 45 μM for SARS-CoV-2 in AS, FP, and FRET assays, respectively. F594-1001 directly binds to SARS-CoV-2 Mac1 and exhibits a dose-dependent inhibition of Mac1 ADP-ribosylhydrolase activity [1].
    F594-1001
  • HY-157150
    mAC2-IN-1

    		Adenylate Cyclase Infection
    mAC2-IN-1 (compound 14) is a potent and selective human adenylate cyclases (mACs) inhibitor with an IC50 of 4.45 μM. mAC2-IN-1 has low activity on mAC1 and mAC5 [1].
    mAC2-IN-1
  • HY-163785
    1"-α-Azido-RDPr

    		SARS-CoV Infection
    1"-α-Azido-RDPr (Compound 11) is an analog of adenosine diphosphate ribose, and exhibits inhibitory efficacy against the SARS-CoV-2 nonstructural protein macodomain SARS-CoV-2 NSP3 Mac1 with an IC50 of 30 nM [1].
    1
  • HY-150064
    SARS-CoV-2 nsp3-IN-2

    		SARS-CoV Infection
    SARS-CoV-2 nsp3-IN-2 is a macrodomain (Mac1) inhibitor with IC50 value of 180 μM. SARS-CoV-2 nsp3-IN-2 is a small molecule chemical probe and can be used for the research of viral [1].
    SARS-CoV-2 nsp3-IN-2

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