Bayer-18

Cat. No.: HY-18315: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Bayer-18 is an inhibitor for TYK2. Bayer-18 inhibits the viability of ALCL cell K299, SR786, Mac1 and Mac2a with IC₅₀ of 2-3 µM, and induces apoptosis in K299 and SR786.

For research use only. We do not sell to patients.

Bayer-18 Chemical Structure

CAS No. : 1251752-12-1

Size	Price	Stock	Quantity
5 mg	USD 430	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 690	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1380	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Bayer-18 is an inhibitor for TYK2. Bayer-18 inhibits the viability of ALCL cell K299, SR786, Mac1 and Mac2a with IC₅₀ of 2-3 µM, and induces apoptosis in K299 and SR786^[1].

IC₅₀ & Target

Tyk2

Molecular Weight

390.46

Formula

C₁₉H₂₇FN₆O₂

CAS No.

1251752-12-1

Appearance

Solid

Color

White to off-white

SMILES

O=C(NC(C)(C)C)NC1=CC=CC(NC2=NC=C(C(NC(C)(CO)C)=N2)F)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (320.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5611 mL	12.8054 mL	25.6108 mL
5 mM	0.5122 mL	2.5611 mL	5.1222 mL
10 mM	0.2561 mL	1.2805 mL	2.5611 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Prutsch N, et al., Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma. Leukemia. 2019 Mar;33(3):696-709. doi: 10.1038/s41375-018-0239-1. Epub 2018 Aug 21. Erratum in: Leukemia. 2020 Nov;34(11):3105. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5611 mL	12.8054 mL	25.6108 mL	64.0270 mL
	5 mM	0.5122 mL	2.5611 mL	5.1222 mL	12.8054 mL
	10 mM	0.2561 mL	1.2805 mL	2.5611 mL	6.4027 mL
	15 mM	0.1707 mL	0.8537 mL	1.7074 mL	4.2685 mL
	20 mM	0.1281 mL	0.6403 mL	1.2805 mL	3.2014 mL
	25 mM	0.1024 mL	0.5122 mL	1.0244 mL	2.5611 mL
	30 mM	0.0854 mL	0.4268 mL	0.8537 mL	2.1342 mL
	40 mM	0.0640 mL	0.3201 mL	0.6403 mL	1.6007 mL
	50 mM	0.0512 mL	0.2561 mL	0.5122 mL	1.2805 mL
	60 mM	0.0427 mL	0.2134 mL	0.4268 mL	1.0671 mL
	80 mM	0.0320 mL	0.1601 mL	0.3201 mL	0.8003 mL
	100 mM	0.0256 mL	0.1281 mL	0.2561 mL	0.6403 mL

Bayer-18 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bayer-181251752-12-1Bayer18Bayer 18JAKApoptosisJanus kinaseanaplastic large cell lymphomasALCLK299SR786Mac1Mac2aInhibitorinhibitorinhibit

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