SARS-CoV-2 nsp3-IN-1

Cat. No.: HY-150062 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

SARS-CoV-2 nsp3-IN-1 (Compound 15c) is a Mac1 (SARS-CoV-2 nsp3 macrodomain) inhibitor with the IC₅₀ value of 6.1 μM. SARS-CoV-2 nsp3-IN-1 can inhibit Mac1 ADP-ribosylhydrolase activity. SARS-CoV-2 nsp3-IN-1 demonstrates notable selectivity for coronavirus macrodomains, especially towards SARS-CoV-2 Mac1.

For research use only. We do not sell to patients.

SARS-CoV-2 nsp3-IN-1 Chemical Structure

CAS No. : 2892105-43-8

Size	Price	Stock	Quantity
5 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 940	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1500	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

Molecular Weight

321.33

Formula

C₁₇H₁₅N₅O₂

CAS No.

2892105-43-8

Appearance

Solid

Color

White to light brown

SMILES

OC([C@H](CC1=CNC2=C1C=CC=C2)NC3=NC=NC4=C3C=CN4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (311.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1121 mL	15.5603 mL	31.1207 mL
5 mM	0.6224 mL	3.1121 mL	6.2241 mL
10 mM	0.3112 mL	1.5560 mL	3.1121 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (254 KB) HNMR (222 KB) LCMS (139 KB)

Handling Instructions (2659 KB)

References

[1]. Lavinia M Sherrill, et al. Design, Synthesis and Evaluation of Inhibitors of the SARS-CoV2 nsp3 Macrodomain. bioRxiv. 2022 Feb 28:2022.02.27.482176. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1121 mL	15.5603 mL	31.1207 mL	77.8016 mL
	5 mM	0.6224 mL	3.1121 mL	6.2241 mL	15.5603 mL
	10 mM	0.3112 mL	1.5560 mL	3.1121 mL	7.7802 mL
	15 mM	0.2075 mL	1.0374 mL	2.0747 mL	5.1868 mL
	20 mM	0.1556 mL	0.7780 mL	1.5560 mL	3.8901 mL
	25 mM	0.1245 mL	0.6224 mL	1.2448 mL	3.1121 mL
	30 mM	0.1037 mL	0.5187 mL	1.0374 mL	2.5934 mL
	40 mM	0.0778 mL	0.3890 mL	0.7780 mL	1.9450 mL
	50 mM	0.0622 mL	0.3112 mL	0.6224 mL	1.5560 mL
	60 mM	0.0519 mL	0.2593 mL	0.5187 mL	1.2967 mL
	80 mM	0.0389 mL	0.1945 mL	0.3890 mL	0.9725 mL
	100 mM	0.0311 mL	0.1556 mL	0.3112 mL	0.7780 mL