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Results for "

Neuromedin(S)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (1) Bombesin Receptor (6) Dopamine Receptor (1) Endogenous Metabolite (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (2) Metabolic Disease (6) Neurological Disease (12)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103283

Neuromedin C (porcine) GRP(18-27) (porcine)	Biochemical Assay Reagents	Neurological Disease
Neuromedin C porcine (GRP, 18-27, porcine) is a bombesin-like neuropeptide that can be obtained from porcine spinal cord. Neuromedin C porcine exhibits a potent contractile activity on rat uterus in the characteristic manner of bombesin. Neuromedin C porcine has research potential for neurological-related diseases .

HY-P0241

Neuromedin B 1 Publications Verification	Endogenous Metabolite	Neurological Disease
Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals.

HY-N6629

3'-Methoxyflavonol	Others	Neurological Disease
3'-Methoxyflavonol is a selective agonist of neuromedin U 2 receptor (NMU2R).

HY-P0079

Neuromedin N 2 Publications Verification Neuromedin N (rat, mouse, porcine, canine)	Dopamine Receptor	Neurological Disease
Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes.

HY-103277A

BIM 23042 TFA	Bombesin Receptor	Neurological Disease Metabolic Disease
BIM 23042 TFA, a certain somatostatin (SS) octapeptide analogue, is a selective *neuropeptide neuromedin* B receptor (NMB-R, BB1*) antagonist. BIM 23042 has 100-fold lower affinity for gastrin-releasing peptide (GRP) receptor (BB2). BIM 23042 inhibits Neuromedin B (HY-P0241),* ICI 216140 and DPDM-bombesin ethylamide-induced Ca ²⁺ release .

HY-116216

PD 168368	Bombesin Receptor	Cancer
PD 168368 is a potent, competitive, and selective neuromedin B receptor (NMB-R) antagonist with the K_i of 15–45 nM . PD 168368 is neuromedin B receptor (NMBR; IC₅₀=96 nM) / gastrin-releasing peptide receptor (GRPR IC₅₀=3500 nM) antagonist . PD 168368 also is a mixed FPR1/FPR2/FPR3 agonist with EC₅₀s of 0.57, 0.24, and 2.7 nM, respectively .

HY-P1423A

BA 1 TFA	Bombesin Receptor	Metabolic Disease Cancer
BA 1 TFA is a potent agonist for the bombesin (BB) family of receptors. BA1 binds with high affinity to Bombesin receptor subtype-3 (BRS3), gastrin releasing peptide receptor (GRPR), neuromedin B receptor (NMBR) with IC₅₀s of 6, 0.4, 2.5 nM .

HY-103277

BIM 23042	Bombesin Receptor	Neurological Disease Metabolic Disease
BIM 23042, a certain somatostatin (SS) octapeptide analogue, is a selective *neuropeptide neuromedin* B receptor (NMB-R, BB1*) antagonist. BIM 23042 has 100-fold lower affinity for gastrin-releasing peptide (GRP) receptor (BB2). BIM 23042 inhibits Neuromedin B (HY-P0241),* ICI 216140 and DPDM-bombesin ethylamide-induced Ca ²⁺ release .

HY-124681

NY0116	Others	Metabolic Disease
NY0116 is a neuromedin U receptor 2 (NMUR2) agonist with EC₅₀ values of 27.76 μM for hNMUR1 and 13.61 μM for hNMUR2. NY0116 decreases cAMP while stimulating calcium signaling in stably expressing NMUR2 HEK293 cells .

HY-P1423

BA 1	Bombesin Receptor	Metabolic Disease Cancer
BA 1 is a potent agonist for the bombesin (BB) family of receptors. BA 1 binds with high affinity to Bombesin receptor subtype-3 (BRS3), gastrin releasing peptide receptor (GRPR), neuromedin B receptor (NMBR) with IC₅₀s of 6, 0.4, 2.5 nM .

HY-107761

JMV 390-1	Others	Neurological Disease
JMV 390-1 (Compound 6a) is a potent multipeptidase inhibitor. JMV 390-1 behaves as a full inhibitor of the major neurotensin (NT)/neuromedin N (NN) degrading enzymes in vitro with IC₅₀ values from 30 to 60 nM. JMV 390-1 increases endogenous recovery of NT and NN from slices of mice hypothalamus depolarized with potassium .

HY-103286

PD176252	Bombesin Receptor	Cancer
PD176252 is a potent antagonist of neuromedin-B preferring (BB₁) and gastrin-releasing peptide-preferring (BB₂) receptor with K_is of 0.17 nM and 1 nM for human BB₁ and BB₂ receptors, and 0.66 nM, 16 nM for Rat BB₁ and BB₂ receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC₅₀s of 0.31 and 0.66 μM in HL-60 cells.

Cat. No.	Product Name	Target	Research Area

HY-103283

Neuromedin C (porcine) GRP(18-27) (porcine)	Biochemical Assay Reagents	Neurological Disease
Neuromedin C porcine (GRP, 18-27, porcine) is a bombesin-like neuropeptide that can be obtained from porcine spinal cord. Neuromedin C porcine exhibits a potent contractile activity on rat uterus in the characteristic manner of bombesin. Neuromedin C porcine has research potential for neurological-related diseases .

HY-P1238A

Neuromedin U, rat TFA Neuromedin U (rat) (TFA); Rat neuromedin U-23 TFA	Peptides	Neurological Disease
Neuromedin U, rat TFA is a 23-amino acid brain-gut peptide. Neuromedin U (NMU), through its cognate receptor NMUR2 in the central nervous system, regulates several important physiological functions, including energy balance, stress response, and nociception.

HY-P0241

Neuromedin B 1 Publications Verification	Endogenous Metabolite	Neurological Disease
Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals.

HY-P4682

Neuromedin U-25 (porcine)	Peptides	Cardiovascular Disease
Neuromedin U-25 (porcine) is a uterus stimulating and hypertensive peptides .

HY-P0079

Neuromedin N 2 Publications Verification Neuromedin N (rat, mouse, porcine, canine)	Dopamine Receptor	Neurological Disease
Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes.

HY-P1239

Neuromedin S(rat)	Peptides	Neurological Disease
Neuromedin S(rat) is a 34-amino acids peptide from rat Neuromedin S. Neuromedin S is a neuropeptide isolated from rat brain. Neuromedin S acts as a ligand for the G protein-coupled receptor FM4/TGR-1

HY-P1239A

Neuromedin S(rat) TFA	Peptides	Neurological Disease
Neuromedin S(rat) TFA is a 34-amino acids peptide from rat Neuromedin S. Neuromedin S is a neuropeptide isolated from rat brain. Neuromedin S acts as a ligand for the G protein-coupled receptor FM4/TGR-1

HY-P5084

Neuromedin S (human)	Peptides	Neurological Disease
Neuromedin S (human) is a neuropeptide that contains 33 amino acids.? Neuromedin S (human)has been identified in the brain as an endogenous ligand for the orphan G-protein coupled receptor (GPCR) FM-4/TGR-1 and acts on the neuromedin U (NMU) receptor 2 (NMUR2) in the regulation of body weight homeostasis .

HY-P2378

Neuromedin U-25 (human)	Peptides	Cardiovascular Disease
Neuromedin U-25 human is the active form of neuromedin U in human. Neuromedin U-25 human inhibits glucose-stimulated insulin secretion, which leads to early-onset obesity. Neuromedin U-25 serves as vasoconstrictor in human vascular beds .

HY-P1238

Neuromedin U, rat Neuromedin U (rat); Rat neuromedin U-23	Peptides	Neurological Disease
Neuromedin U, rat is a 23-amino acid brain-gut peptide. Neuromedin U (NMU), through its cognate receptor NMUR2 in the central nervous system, regulates several important physiological functions, including energy balance, stress response, and nociception.

HY-103277

BIM 23042	Bombesin Receptor	Neurological Disease Metabolic Disease
BIM 23042, a certain somatostatin (SS) octapeptide analogue, is a selective *neuropeptide neuromedin* B receptor (NMB-R, BB1*) antagonist. BIM 23042 has 100-fold lower affinity for gastrin-releasing peptide (GRP) receptor (BB2). BIM 23042 inhibits Neuromedin B (HY-P0241),* ICI 216140 and DPDM-bombesin ethylamide-induced Ca ²⁺ release .

HY-103277A

BIM 23042 TFA	Bombesin Receptor	Neurological Disease Metabolic Disease
BIM 23042 TFA, a certain somatostatin (SS) octapeptide analogue, is a selective *neuropeptide neuromedin* B receptor (NMB-R, BB1*) antagonist. BIM 23042 has 100-fold lower affinity for gastrin-releasing peptide (GRP) receptor (BB2). BIM 23042 inhibits Neuromedin B (HY-P0241),* ICI 216140 and DPDM-bombesin ethylamide-induced Ca ²⁺ release .

HY-P10267

Neuromedin (B-30)	Peptides	Others
Neuromedin B-30 is the neuropeptide, which is orignally isolated from porcine brain and spinal cord, and may exhibit activity in stimulating smooth-muscle .

HY-P3134

CPN-267	Peptides	Metabolic Disease
CPN-267 (compound 7b) is a selective neuromedin U receptor 1 (NMUR1) agonist with the EC₅₀ of 0.25 nM. CPN-267 suppresses body weight gain in mice and can be used for study of obesity .

HY-P4763

Neuromedin U-8 (porcine)	Peptides	Others
Neuromedin U-8 (porcine) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P1423

BA 1	Bombesin Receptor	Metabolic Disease Cancer
BA 1 is a potent agonist for the bombesin (BB) family of receptors. BA 1 binds with high affinity to Bombesin receptor subtype-3 (BRS3), gastrin releasing peptide receptor (GRPR), neuromedin B receptor (NMBR) with IC₅₀s of 6, 0.4, 2.5 nM .

HY-P1423A

BA 1 TFA	Bombesin Receptor	Metabolic Disease Cancer
BA 1 TFA is a potent agonist for the bombesin (BB) family of receptors. BA1 binds with high affinity to Bombesin receptor subtype-3 (BRS3), gastrin releasing peptide receptor (GRPR), neuromedin B receptor (NMBR) with IC₅₀s of 6, 0.4, 2.5 nM .

Neuromedin B 1 Publications Verification	Structural Classification Natural Products Animals Source classification Endogenous metabolite	Endogenous Metabolite
Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals.

3'-Methoxyflavonol	Flavonols Structural Classification Flavonoids Microorganisms Source classification	Others
3'-Methoxyflavonol is a selective agonist of neuromedin U 2 receptor (NMU2R).

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Neuromedin(S)

Inhibitors & Agonists

Peptides

NaturalProducts

Natural
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