2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Neuromedin N

Neuromedin N  (Synonyms: Neuromedin N (rat, mouse, porcine, canine))

Cat. No.: HY-P0079 Purity: 99.61%
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Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Neuromedin N Chemical Structure

Neuromedin N Chemical Structure

CAS No. : 92169-45-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 177 In-stock
Solution
10 mM * 1 mL in Water USD 177 In-stock
Solid
5 mg USD 108 In-stock
10 mg USD 156 In-stock
25 mg USD 336 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 3 publication(s) in Google Scholar

Neuromedin N Related Antibodies

Top Publications Citing Use of Products

    Neuromedin N purchased from MedChemExpress. Usage Cited in: Cell Signal. 2018 Dec;52:147-154.  [Abstract]

    Human PASMCs are treated with Neuromedin N (400 nM) for various durations, cell lysates are prepared and phosphorylated forms of ERK (pERK), Stat3 (pStat3), Raf-1 (pRaf-1) and MEK (pMEK) are monitored by Western blotting using pERK1/2 (T202/Y204), pStat3 (Y705), pRaf-1 (S338) and pMEK1/2 (S217/221) antibodies.

    View All Dopamine Receptor Isoform Specific Products:

    View All Isoforms
    Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes.

    IC50 & Target

    D2 Receptor

     

    In Vitro

    Neuromedin N competitively inhibits the binding of neurotensin to rat brain synaptic membranes with a 19-fold lower potency than neurotensin and is rapidly inactivated by brain synaptic peptidases[1]. It competitively inhibits neurotensin binding to rat brain synaptic membranes and has increased potency in the presence of the peptidase inhibitor bestatin[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Neuromedin N Related Antibodies
    Molecular Weight

    745.95

    Formula

    C38H63N7O8
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    Lys-Ile-Pro-Tyr-Ile-Leu
    Sequence Shortening

    KIPYIL
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (67.03 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.3406 mL 6.7029 mL 13.4057 mL
    5 mM 0.2681 mL 1.3406 mL 2.6811 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL (67.03 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.3406 mL 6.7029 mL 13.4057 mL 33.5143 mL
    5 mM 0.2681 mL 1.3406 mL 2.6811 mL 6.7029 mL
    10 mM 0.1341 mL 0.6703 mL 1.3406 mL 3.3514 mL
    15 mM 0.0894 mL 0.4469 mL 0.8937 mL 2.2343 mL
    20 mM 0.0670 mL 0.3351 mL 0.6703 mL 1.6757 mL
    25 mM 0.0536 mL 0.2681 mL 0.5362 mL 1.3406 mL
    30 mM 0.0447 mL 0.2234 mL 0.4469 mL 1.1171 mL
    40 mM 0.0335 mL 0.1676 mL 0.3351 mL 0.8379 mL
    50 mM 0.0268 mL 0.1341 mL 0.2681 mL 0.6703 mL
    60 mM 0.0223 mL 0.1117 mL 0.2234 mL 0.5586 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Neuromedin N Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Neuromedin N92169-45-4Neuromedin N (rat, mouse, porcine, canine)Dopamine ReceptorInhibitorinhibitorinhibit

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