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NY0116 is a neuromedin U receptor 2 (NMUR2) agonist with EC50 values of 27.76 μM for hNMUR1 and 13.61 μM for hNMUR2. NY0116 decreases cAMP while stimulating calcium signaling in stably expressing NMUR2 HEK293 cells.

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NY0116 Chemical Structure

NY0116 Chemical Structure

CAS No. : 1003000-59-6

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NY0116 Related Antibodies

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Description

NY0116 is a neuromedin U receptor 2 (NMUR2) agonist with EC50 values of 27.76 μM for hNMUR1 and 13.61 μM for hNMUR2. NY0116 decreases cAMP while stimulating calcium signaling in stably expressing NMUR2 HEK293 cells[1].

In Vitro

NY0116 has potent dose-dependent inhibition of cAMP (EC50 of 1.69 nM) in HEK293 cells stably expressing hNMUR2. NY0116 also stimulates calcium signaling in cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NY0116 Related Antibodies
In Vivo

NY0116 (3-30 mg/kg; SC; ; for 14 days) decreases bodyweight, visceral adipose tissue, and cholesterol on a high‐fat diet[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male diet induced obese (DIO) C57BL/6J mice age 18 weeks and 8 age[1]
Dosage: 3, 10, 30 mg/kg
Administration: Subcutaneous injection; for 14 days
Result: Significantly decreased bodyweight compared to vehicle, whereas mice were maintained on a high-fat diet.
Molecular Weight

345.44

Formula

C22H23N3O
CAS No.
SMILES

NC(NCCOC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=N
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NY0116 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NY01161003000-59-6NY 0116NY-0116OthersNMUR2 AgonistcAMPcalcium signalingmetabolic disordersInhibitorinhibitorinhibit

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