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Results for "

Porcn

" in MedChemExpress (MCE) Product Catalog:

16

Inhibitors & Agonists

2

Fluorescent Dye

2

Biochemical Assay Reagents

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15825
    IWP L6
    2 Publications Verification

    Porcn Inhibitor III

    		 Porcupine Cancer
    IWP L6 (Porcn?Inhibitor?III) is a Porcn inhibitor with an EC50 of 0.5 nM.
    IWP L6
  • HY-111472
    Porcn-IN-1

    		Porcupine Cancer
    Porcn-IN-1 is potent porcupine inhibitor with an IC50 of 0.5±0.2 nM.
    Porcn-IN-1
  • HY-100536
    IWP-3

    		Wnt Cancer
    IWP-3 is an potent inhibitor of Wnt production with an IC50 of 40 nM. IWP-3 inhibits Porcupine (Porcn) function thereby blocking palmitoylation of Wnt proteins. IWP-3 inhibits CK1γ3 and CK1ε only moderately and does not inhibit CK1α .
    IWP-3
  • HY-17545
    LGK974
    Maximum Cited Publications
    28 Publications Verification

    WNT974

    		 Porcupine Cancer
    LGK974 (WNT974) is an orally bioavailable and specific Porcupine (PORCN) inhibitor with an IC50 of 0.1 nM .
    LGK974
  • HY-15659
    Wnt-C59
    20+ Cited Publications

    C59

    		 Porcupine Wnt Cancer
    Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC50 of 74 pM.
    Wnt-C59
  • HY-156551
    Porcn-IN-2

    		Wnt Cancer
    Porcn-IN-2 (Example 107) is a Wnt inhibitor, with an IC50 value of 0.05 nM. Porcn-IN-2 can be used for research of cancer, sarcoma, melanoma, skin cancer, haematological tumors, lymphoma, carcinoma, and leukemia, etc .
    Porcn-IN-2
  • HY-RS10881
    PORCN Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    PORCN Human Pre-designed siRNA Set A contains three designed siRNAs for PORCN gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PORCN Human Pre-designed siRNA Set A
    PORCN Human Pre-designed siRNA Set A
  • HY-RS10882
    Porcn Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Porcn Mouse Pre-designed siRNA Set A contains three designed siRNAs for Porcn gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Porcn Mouse Pre-designed siRNA Set A
    Porcn Mouse Pre-designed siRNA Set A
  • HY-RS10883
    Porcn Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Porcn Rat Pre-designed siRNA Set A contains three designed siRNAs for Porcn gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Porcn Rat Pre-designed siRNA Set A
    Porcn Rat Pre-designed siRNA Set A
  • HY-164547
    WHN-88

    		Porcupine Wnt β-catenin Cancer
    WHN-88 is a Porcupine (PORCN) inhibitor. WHN-88 can eliminate the palmitoylation of Wnt ligands, preventing their secretion and subsequent Wnt/β-catenin signaling. WHN-88 can inhibit cancer cell stemness and suppress the occurrence and development of breast tumors in MMTV-Wnt1 transgenic mice .
    WHN-88
  • HY-107570
    IWP-12

    		Acyltransferase Others
    IWP-12 is a potent inhibitor of porcupine (PORCN) and inhibits cell-autonomous Wnt signaling with an IC50 of 15 nM .
    IWP-12
  • HY-18988
    ETC-159
    5+ Cited Publications

    ETC-1922159

    		 Porcupine Wnt Cancer
    ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. ETC-159 inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
    ETC-159
  • HY-15659G
    Wnt-C59

    C59

    		 Porcupine Wnt Cancer
    Wnt-C59 (C59) GMP is a GMP grade Wnt-C59 (HY-15659). Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC50 of 74 pM.
    Wnt-C59
  • HY-100853
    IWP-O1

    		Porcupine Wnt Cancer
    IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells. IWP-O1 prevents the secretion of Wnt proteins. IWP-O1 suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells .
    IWP-O1
  • HY-13912
    IWP-2
    15+ Cited Publications

    		 Wnt Porcupine Casein Kinase Cancer
    IWP-2 is an inhibitor of Wnt processing and secretion with an IC50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC50 of 40 nM for the gatekeeper mutant M82FCK1δ .
    IWP-2
  • HY-13912G
    IWP-2
    1 Publications Verification

    		 Wnt Cancer
    IWP-2 (GMP) is IWP-2 (HY-13912) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. IWP-2 is an inhibitor of Wnt processing and secretion with an IC50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and blocks Wnt ligand palmitoylation .
    IWP-2

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