2. Stem Cell/Wnt
  3. Porcupine
  4. IWP L6

IWP L6  (Synonyms: Porcn Inhibitor III)

Cat. No.: HY-15825 Purity: 99.50%
SDS COA Handling Instructions

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IWP L6 (Porcn?Inhibitor?III) is a Porcn inhibitor with an EC50 of 0.5 nM.

For research use only. We do not sell to patients.

IWP L6 Chemical Structure

IWP L6 Chemical Structure

CAS No. : 1427782-89-5

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5 mg USD 53 In-stock
10 mg USD 78 In-stock
50 mg USD 250 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

IWP L6 Related Antibodies

Top Publications Citing Use of Products

2 Publications Citing Use of MCE IWP L6

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

IWP L6 (Porcn?Inhibitor?III) is a Porcn inhibitor with an EC50 of 0.5 nM.

IC50 & Target

EC50 Value: 0.5 nM[1]
In Vitro

IWP-L6 (Porcn?Inhibitor?III) effectively suppressed the phosphorylation of dishevelled 2 (Dvl2) in HEK293 cells, a biochemical event associated with many Wnt-dependent cellular responses. IWP-L6 inhibits Wnt mediated branching morphogenesis in cultured embryonic kidneys [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IWP L6 Related Antibodies
In Vivo

IWP-L6 (Porcn?Inhibitor?III) is stable in human plasma over 24 h, it was rapidly metabolized in rat plasma (t1/2 = 190 min), murine plasma (t1/2 = 2 min), and the murine liver S9 fractions (t1/2 = 26 min). The major metabolites are the amide cleavage products. Similar species-dependent metabolitic profiles due to the involvement of carboxylesterase (CES) have been reported with other drug candidates. Despite its modest metabolic stability in mouse-derived plasma, IWP-L6 was highly active in zebrafish. IWP-L6 exhibited more potent activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

472.58

Formula

C25H20N4O2S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=NC=C(C2=CC=CC=C2)C=C1)CSC3=NC(CCS4)=C4C(N3C5=CC=CC=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 22.5 mg/mL (47.61 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1160 mL 10.5802 mL 21.1604 mL
5 mM 0.4232 mL 2.1160 mL 4.2321 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.50%

SDS (393 KB)

COA (249 KB) HNMR (435 KB) LCMS (88 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1160 mL 10.5802 mL 21.1604 mL 52.9009 mL
5 mM 0.4232 mL 2.1160 mL 4.2321 mL 10.5802 mL
10 mM 0.2116 mL 1.0580 mL 2.1160 mL 5.2901 mL
15 mM 0.1411 mL 0.7053 mL 1.4107 mL 3.5267 mL
20 mM 0.1058 mL 0.5290 mL 1.0580 mL 2.6450 mL
25 mM 0.0846 mL 0.4232 mL 0.8464 mL 2.1160 mL
30 mM 0.0705 mL 0.3527 mL 0.7053 mL 1.7634 mL
40 mM 0.0529 mL 0.2645 mL 0.5290 mL 1.3225 mL
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IWP L6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IWP L61427782-89-5Porcn Inhibitor IIIIWP L 6IWP L-6PorcupineInhibitorinhibitorinhibit

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